Hi. With this video, we will discuss the various mechanisms by which leprosy leads to Schwann Cell and nerve destruction. This will clear our concepts and make us better prepared for treating our patients. This video is directed towards dermatologists and is not at all advisory for non-medical personnel.
Introduction - 02:44
Leprosy Infection - 05:44
Mechanisms of nerve damage - 10:18
A. Features of nerve damage - 11:37
Structure of a nerve bundle - 18:05
B. Entry of M. Leprae - 21:04
C. Infection of the Schwann Cells - 26:45
D. Immune-mediated damage: T-Cells - 38:40
D. Immune-mediated damage: Apoptosis - 43:31
D. Immune-mediated damage: Collateral Damage - 47:08
D. Immune-mediated damage: COmplement System - 52:00
E. Inflammatory Cytokines - 54:26
F. Auto-immune mediated damage - 57:12
G. Mycobacterial Antigens - 58:24
H. Additional mechanisms - 01:00:15
Recommendation: Immunology of Leprosy Part 1 and 2 - 01:04:42
Further Reading - 01:06:37
End - 01:07:03
Links for video recommendations:
Part 1 - Immunology Of Leprosy: • Part 1 - Immunology Of...
Part 2 - Manipulation of Immune System In Leprosy: • Part 2 - Manipulation ...
Good articles on Pathomechanisms of nerve damage in leprosy:
1. Spierings E, De Boer T, Zulianello L, Ottenhoff TH. Novel mechanisms in the immunopathogenesis of leprosy nerve damage: the role of Schwann cells, T cells and Mycobacterium leprae. Immunol Cell Biol. 2000 Aug;78(4):349-55. doi: 10.1046/j.1440-1711.2000.00939.x. PMID: 10947859
2. Wilder-Smith EP, Van Brakel WH. Nerve damage in leprosy and its management. Nat Clin Pract Neurol. 2008 Dec;4(12):656-63. doi: 10.1038/ncpneuro0941. Epub 2008 Nov 11. PMID: 19002133..
3. Serrano-Coll H, Salazar-Peláez L, Acevedo-Saenz L, Cardona-Castro N. Mycobacterium leprae-induced nerve damage: direct and indirect mechanisms. Pathog Dis. 2018 Aug 1;76(6). doi: 10.1093/femspd/fty062. PMID: 30052986.
Негізгі бет Patho-Mechanism of Nerve Damage in Leprosy: mechanisms, process, key players
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