@@israelduarte1189 and that's why it's (somehow) funny
@palwashasahar1146
Жыл бұрын
Very well explained both pathways, thank you
@NMKL211
2 жыл бұрын
Means a lot to me. Thank you respected sir for such an informative video it really helps me a lot in clearing my confusion and in my assignment making.
@timblackburn1593
Жыл бұрын
Fantastic summary, thank you
@auroradiaz3148
5 жыл бұрын
Muy buen video ! Thank you so much ...greetings from Perú :)
@CatalystUniversity
5 жыл бұрын
Thank you, Aurora!
@MuhammadNaeem-lr4vp
Жыл бұрын
well, as per my knowledge you have missed the work of secretases as Alpha and Gamma secretases cause a healthy breakdown of protein while beta cleavage is misdirected. But in the video, you said gamma-secretase cleavage cause disturbance that's not true. Please go through the latest articles and correct me if I am wrong. Thanks
@leila189
2 жыл бұрын
merci beaucoup !
@atijorogloria4070
3 жыл бұрын
So helpful
@rivamuhammad794
3 жыл бұрын
Thank you soooo much
@killianpapail9324
2 жыл бұрын
Hi, very good work, thank you. I have a question : what is the link between Tau misfloding and hyperphosphorylation of Tau ? Does Tau is hyperphosphorylated because it is misfloding ? If someone anserw to my question, I thank him in advance. Happy new year 2022!
@dartholiver
5 жыл бұрын
Hey Kevin, could you post a link to the articles that you used for this video, i would like to credit the pictures :)
@CatalystUniversity
5 жыл бұрын
No problem: 1) molecular characteristics of alzheimer's disease: science.sciencemag.org/content/358/6359/45/tab-figures-data 2) Tau microtubules: www.sciencedirect.com/science/article/pii/S0531556516305800 Other picture: 3) molecularneurodegeneration.biomedcentral.com/articles/10.1186/1750-1326-2-22
@omargarciafernandez7376
3 жыл бұрын
I was wondering, why does the calcium influx cause apoptosis and not necrosis?
@johnmandrake8829
3 жыл бұрын
the intro made me question everything
@hydrocarrot229
2 жыл бұрын
Thanks man, but I have a question what is sAPP
@liamflaherty6362
2 жыл бұрын
Thanks for the informative video, the intro is a bit fucked but everything else is gold. Cheers Cobba
@kandiceblu1
7 ай бұрын
Is ALS a Prion Disease?
@ryanrohrbacker7431
11 ай бұрын
this is honestly not right at all in regards to pathophysiology and microphysiology of how plaques and tangles are caused . The basics are mentioned just not the intricacies on how everything comes together. for example tau proteins don't unfold , they’re hyper polarized through hyperphosphorylation from the amyloid beta plaques outside the neurons themselves causing clumps giving a weak cytoskeleton within the neuron. Then with the weak and half dead neurons they clump up and cause neurofibrillary tangles. Amyloid beta plaques are a whole other beast, they’re outside the neuron not within the neuron.
@celinat8622
8 ай бұрын
Had exactly this doubt, I'm learning about prions and the diseases they cause. I think the PrP protein has nothing to do with tau and amyloid beta right?
@bonnenaturel6688
15 күн бұрын
@@celinat8622 Other resources say it is double prion disease involving tau prions and amyloid prions, which is difficult to believe. I believe the researcher is Prusiner.
Пікірлер: 27