Phenelzine (Nardil)- a lifesaver MAOI that puts the SSRIs to shame! Spread the great work of Dr. Ken Gillman!
@jessqinn7702
2 жыл бұрын
Wonderful news!! Thank you everyone for all the hard work! MAOI medication has been very helpful to me after many, many years of trying nearly everything else. And hardly any health professionals knew about it, or understood the interactions etc - and so was very difficult to explain when in crisis or at and emergency department. Found this channel years ago (and was recommended by my then psychiatrist) and so so happy to see all the new developments. Wonderful. Thank you.
@henrymorgan9564
2 жыл бұрын
Thank you Dr Gillman for your tireless work in spreading the knowledge and importance of MAOI antidepressants; these medications are vital to the existence of so many around the world.
@howardgranger1749
2 жыл бұрын
Great stuff Ken. The ignorance surrounding MAOIs even, or perhaps especially, amongst psychiatrists is staggering.
@hazelbeth173
2 жыл бұрын
In Australia Phenelzine is now available once again from local pharmacies
@psychotropicalresearch5653
2 жыл бұрын
Which version?
@tpl6963
2 жыл бұрын
I hope this will have an on-the-ground effect. I still have no luck in the UK with psychiatrists. Thanks Dr Gillman
@jessqinn7702
2 жыл бұрын
Absolutely cheering while watching! Such such good news!
@caroldoyle70
2 жыл бұрын
Excellent news Doctor. Unavailability of tranylcypromine concerns me as it is the only drug that has worked for me. The donation link on this video doesn’t work though..took me to a ‘page not known’ page. I look forward to the improved website and further developments. Many many thanks. 🏴❤️🏴
@dustygatrell-ru7tg
3 ай бұрын
Wheres his videos on benzo induced nueroinflamattion. I cant find anything on it. Very important.
@maurice5402
2 жыл бұрын
Hello doctor! Thanks for putting out these videos. They're very informative. My psychiatrist wants to add moclobemide alongside the buspirone I'm using for my anxiety. What's your opinion on this combination?
@psychotropicalresearch5653
2 жыл бұрын
Most of the experts in the group consider MOC to be a very weak drug (I agree) although it can be sufficient for some people, it has the advantage of having few side-effects. So if you're not in a rush to get better it might be worth a try. No problem combining it with the BUS
@Lipolimtown
2 жыл бұрын
Have you heard of the new medication Ulotaront? Wondering if it would be helpful for anhedonia in normal people. Also would like your opinion on Mglur1 treatments, as well as XEN 1101 the epilepsy medication for depression/ anhedonia and the Gpld1 protein. Thank you
@psychotropicalresearch5653
2 жыл бұрын
Best to contact me through the website for general questions related to videos
@alexkay3340
2 жыл бұрын
Question about MAOI use: does anyone know why the Nardil product instructions talk about lowering the dose down to 15mg every other day? I don't believe people actually do this, or that it would work, so how did it end up as official guidance for dosing it?
@mogotrevo
2 жыл бұрын
It’s the minimum amount to supposedly maintain 100% MAO inhibition after you’ve fully inhibited it.
@psychotropicalresearch5653
2 жыл бұрын
Theoretically, because they are irreversible, it should be possible to take the dose once every 2 to 3 days. That has been demonstrated probably to be the case for Parkinsons disease with selegiline. However, with PLZ there is the additional mechanism of the inhibition of Gabba transaminase, and that is shorter-lasting and reversible, so that effect of the medication requires regular twice daily dosing. It is a great shame that no one has ever done the equivalent experiment with TCP in depression -- to attempt to demonstrate that twice or thrice weekly dosing is just as good. It may or may not be, we just don't know for sure.
@alexkay3340
2 жыл бұрын
@@psychotropicalresearch5653 Thanks for the reply. It still seems strange to me that this ended up in the official product instructions, and such a low dose as only 15mg every other day, if this was based on it being theoretically enough to sustain MAO inhibition. You would think they should maybe have done real-world experiments before advising this dosage. I haven't heard of anyone dropping the dose that low and continuing to get an antidepressant effect.
@psychotropicalresearch5653
2 жыл бұрын
@@alexkay3340 the official information in the product brochure for older drugs is sometimes quite inaccurate. The FDA don't have their staff with the relevant knowledge and expertise to understand either that, or complex drug interactions, such as serotonin toxicity. That is why there are many false warnings to do with e.g. sterns,, TCAs, and other drugs. What are usually regarded as authoritative sources of information are no longer so. If your doctor seems uncertain and confused it may not be their fault.
@NickArcade
2 жыл бұрын
Your microphone works so much better when it's closer to you
@psychotropicalresearch5653
2 жыл бұрын
Yes indeed, I will make sure I keep it that way
@psychotropicalresearch5653
2 жыл бұрын
Also, did you notice that the camera is much better, the previous Logitech camera wasn't so good and the software was incompatible with the new Apple M1 Pro processor -- this Elgato camera is better. I also have a special camera-light now (Elgato again) and have moved my desk so the natural light comes from both sides as you may notice from the position of the bookcase.
@NickArcade
2 жыл бұрын
@@psychotropicalresearch5653 With the Blue Yeti microphone, it works better when it is pointed upright instead of toward you. If you have it toward you then it won't work as well as the modules inside were made to collect your voice when the mic is pointed upright.
@psychotropicalresearch5653
2 жыл бұрын
@@NickArcade useful info, thank you Nick. Can you point me to more detailed information on this, I would be interested to learn more, especially about which pattern setting might be best
@NickArcade
2 жыл бұрын
@@psychotropicalresearch5653 A boom arm will help you quite significantly as you'll be able to clamp it to your desk and move the microphone freely around, including closer to your mouth which will make full potential of the microphone by making you sound clearer and avoid reverb. I hope that helps
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