Senescent cells accumulate with age. Studies have shown that removing senescent cells can alleviate symptoms of aging. However, a recent study has put this into question...
References;
Grosse et al., Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan, Cell Metabolism
(2020), doi.org/10.101...
Xu, M., Pirtskhalava, T., Farr, J.N. et al. Senolytics improve physical function and increase lifespan in old age. Nat Med 24, 1246-1256 (2018). doi.org/10.103...
Baker, D., Wijshake, T., Tchkonia, T. et al. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 479, 232-236 (2011). doi.org/10.103...
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