This took me a long time to make so I hope you enjoy it & would appreciate a thumbs up/share !! :D Thanks!
@johnjallen
3 жыл бұрын
Since you asked, sure.
@joeblack4026
3 жыл бұрын
What program did you use for this? Thanks
@themacso4157
2 жыл бұрын
Outstanding, thank you very much!
@BrentNally
3 жыл бұрын
Awesome video as always!!! 👏🏼👏🏼👏🏼
@blkshk2466
3 жыл бұрын
The way you were trying to stop yourself from cracking up at your own eye jokes though. 😂
@TheSheekeyScienceShow
3 жыл бұрын
Guilty
@user-od3rl5mc
3 жыл бұрын
Another great video. Lets just say I'm of an age profile where I've started to notice the effects of macular degeneration in the last couple of years. Not a pleasant feeling to know it's a downward trajectory from here. I'll definitely be keeping my "eyes" peeled for future developments! - Cheers.
@TheSheekeyScienceShow
3 жыл бұрын
Thanks!! 😊
@js401
3 жыл бұрын
Thanks so much for trying to explain this amazing information from Sinclair's study:)
@brucebird55
3 жыл бұрын
I have been looking forward to seeing this data published since reading about it in Lifespan. What exciting stuff!
@TheSheekeyScienceShow
3 жыл бұрын
Likewise! 😊
@SolvingAging
3 жыл бұрын
I recently found this channel from Lifespan News and am loooooving it! Thanks!
@RationalAnimations
3 жыл бұрын
This channel is a public service. Keep up the good work :)
@mickmickymick6927
3 жыл бұрын
Thank you so much. If only we had more quality science educators like you instead of people just pushing their ideology or self-image.
@Ragib
3 жыл бұрын
Congrats on the shoutout from David Sinclair :)
@thewinchester8996
2 жыл бұрын
Truly mind blowing and fascinating watch. Thank you for making this information digestible and able to be absorbed somewhat well by someone who’s not in the field. Kinda sad there’s not more talk or hype around this and the impacts it could potentially have on us in the future. Science is truly amazing and the people like you perusing it and developing it for us and the rest of the world are almost like magicians to outsiders. Great video thank you!
@GrindThisGame
3 жыл бұрын
Thanks for the summary of the paper. I will go check out your summary of Lifespan. I've often thought that since the germline preserves all youthfulness that there would be a way in an adult body to reset cells to this state as well. Where is the initial state of youthful methylation stored? This will be interesting when they find it.
@PBAmygdala2021
2 жыл бұрын
Excellent comment!
@neilchristensen538
3 жыл бұрын
Excellent explanation of the Sinclair lab result. Thanks!
@abbasshaik972
3 жыл бұрын
That's nicely explained. Great video to know about the upcoming discovery in future. Dr Sinclair has been doing a phenomenal job on undisturbed facts of the life cycle. Hoping for great outcomes.💙🤝
@Health.First.
3 жыл бұрын
Great analysis!
@Slitherpy
3 жыл бұрын
That DVD analogy was spot on! thanks!
@MakingTomorrowBetter
3 жыл бұрын
Great summary of the process in a tidy and succinct manner :-)
@Noveleffect
3 жыл бұрын
All this is good for simpler systems, but there are complications to taking supplements he suggests , such as resveratrol, and NMN. Sinclair is still a long way from truly unlocking a method to help stop/reversing the aging process. But as it stands, resveratrol causes cellular distress and NMN interferes with thyroid function…there needs to be human studies at some point.
@voidmap6628
2 жыл бұрын
Have you used it ?
@BK-dy8jk
10 ай бұрын
Taking TMG to Conrad, methylation to counteract and the small amounts of resveratrol mixed in fat, but not too excess. Even if we’re not rats, their bodies fantastically
@tonyc5522
3 жыл бұрын
Wow. Love your work. The way you synthesise the information from these studies it’s incredible useful. Keep up the good work. Also thanks for the DNA discount code. I’ll use next time, hopefully brings you benefits that pay for your time and work you put in these videos.
@peterz53
3 жыл бұрын
Thanks for excellent presentation. Interestingly, the Ketone body BHB upregulates OCT4.
@timothymugayi6469
3 жыл бұрын
Very well explained!
@Caleb-mh9sd
3 жыл бұрын
Super impressive. Thank you God bless
@vincentweisser1518
3 жыл бұрын
Fantastic summary, thanks!! You should have a patreon for direct support!
@TheSheekeyScienceShow
3 жыл бұрын
Thanks!! Am considering maybe for next year! 😊
@rossbarker3362
3 жыл бұрын
Many Questions in the Video, do we still think NMN Powder, Resveritrol , Metformin and Aspirin is still a valid therapy?
@NaimaZakaria
3 жыл бұрын
Great recap.
@pavelbaidurov228
3 жыл бұрын
But, stem cells still have the telomeres, so they will die at the age of 120(theorethical maximum) but in the young condition? And can you deliver this Yamanaka factors to all neurons/stem cells with just a several specialized viruses? direct local injections is not ok.
@user-lu6ce4yc9g
3 жыл бұрын
Can b12 and folic acid cause aging faster because of methylation?
@richardhall5238
3 жыл бұрын
Great video, nicely explained. One thing I wonder is why is it thought that there's some memory of the earlier epigenetic state rather than the excess methylation in older mice being remove more randomly?
@TheSheekeyScienceShow
3 жыл бұрын
Thanks! So, the reason they think that is because there must be some 'information' that can dictate why some, not all, marks are removed. A random mechanism may enter a different cell state, not a rejuvenated state, if that makes sense! 😊 (at least this is how i understand it)
@anon5523
3 жыл бұрын
@@TheSheekeyScienceShow From what I understand of methylation, the markers of what to methylate are in the DNA. DNA methylation is essential for embryonic development, so some of the methylation is "planned". DNA demethylation is needed for making sex cells and stem cells. Embryos obviously must start young, but then they divide and differentiate (like teratomas!). There doesn't seem to be any selective pressure to evolve a set of transcription factors to restore differentiated cells to a young state. I predict that we'll need to design our own proteins to demethylate specific DNA sites or, alternatively, to globally demethylate while leaving key sites methylated.
@SHINjuju
3 жыл бұрын
no one: optic nerve: im baby
@SamA-en3iq
2 жыл бұрын
Are you able to do a presentation on MSCs and exosomes as it relates to connective tissue regeneration (cartilage, muscle, tendons, skin etc.) Thanks.
@tkbarath
3 жыл бұрын
Enjoyed your explanation very much 👏
@douglasauruss
3 жыл бұрын
What would it take to allow very aged and resultingly sick people, even possibly those with paralysis due to nerve damage, to be able to undergo this treatment voluntarily, since they have nothing really to lose and not much longer to live at this point? Do drugs and therapies ever get a pass for scenarios like that? It would sure help us know how will they work sooner than the many years it takes to test these things thoroughly for healthy people.
@PsiCorps85
2 жыл бұрын
Are there any fruits or vegetables which activate the three useful genes?
@DiyetisyenAhmetAkbulut
2 жыл бұрын
Amazing.
@nicolaspadron3167
3 жыл бұрын
Okay, how do we get the yamanaka proteins to make us younger? Clinical trials. Just enough to avoid teratomas.
@guilhermejeremias322
9 ай бұрын
Time for an update since the work with primates has been done already!
@jackfrost884
6 ай бұрын
You got a link?
@thefruit
3 жыл бұрын
wow this mic is so much better than the other ones, which one did you get?
@TheSheekeyScienceShow
3 жыл бұрын
Thanks, i use a KLIM microphone, but ngl, do a lot of audio editing with adobe audition ppst recording! 😊
@bijanbonyadi1787
Жыл бұрын
Good video
@pavelbaidurov228
3 жыл бұрын
Like from Russia!
@figureskatingman
3 жыл бұрын
osk treatment ,, how much cost , is there any supplement
@bencyber8595
Жыл бұрын
Shinya Yamanaka
@ryanm9565
2 жыл бұрын
How would this be applied in humans?
@rgonzalo511
2 жыл бұрын
It can't be, not right now atleast. Too early in development so we need to do more research.
@ryanm9565
2 жыл бұрын
@@rgonzalo511 I heard Sinclair talking about testing it in primates right now. Hopefully they can come up with something safe in 10 years.
@rgonzalo511
2 жыл бұрын
@@ryanm9565 First let's hope this treatments work in primates. Way too many treatments that worked for mice that didn't translate to other species, including humans. It's gonna take time, let's just be patient.
@TexasFightTexas
2 жыл бұрын
Has this research been replicated by others? Sinclair has had some past questionable research
@michaelconway7853
3 жыл бұрын
Interesting theory however I wouldn’t use a Staten hypothesis statins are poison.
@TheSheekeyScienceShow
3 жыл бұрын
Oh really, what studies show this? 😊
@michaelconway7853
3 жыл бұрын
Dr. Mercola Dr. Sherry Rogers Dr. L Sears Dr. Joel Whillock Dr. Sherry a Rogers Dr. Peter Glidden should I go on
@Chris-kr7gg
3 жыл бұрын
Agreed that statins are poison! Other then a predisposition to certain disease the majority of people are poisoned with terrible food and other poor choices which induce the need for statins which cause a plethora of side effects. Which keep people consumed with medication until they die. Does that sound like a good treatment for people ? The pharmaceutical and medical industry have always been closely affiliated with eachother. Health is the truth wealth of the world today, it's just a shame that certain parts of society and governments don't want a healthy society as a whole, if the average public is healthy, that is a powerful force to contend with, what controlling group would want a majority of the population healthy and strong ? They can't be controlled easily then.
@IshYowe
3 жыл бұрын
How do they only express the genes 2 days a week?
@richardhall5238
3 жыл бұрын
They use what's called Tetracycline-controlled transcriptional activation. It's a system that will turn the genes on when doxycline is added to the drinking water of the mice.
@pavelbaidurov228
3 жыл бұрын
I hope some artists will be inspired by this study and we will get some cool book/movie/anime/video game where people start to live 5-10 times longer and society get a lot of the new social and political troubles.
@andrewdrummond8576
2 жыл бұрын
Don't think too many people including myself will understand this presentation. I certainly do not want to become over 90 years old.
@archisashefa4303
2 жыл бұрын
I wish they find a mechanism to regrow teeth in human ....
@jdlc903
3 жыл бұрын
Teratomas sound terrifying and gross; tumors of muscle bone and hair
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