جزاك الله خير يا دكتور. لو سمحتوا كيف احصل المحاضرة pdf؟
@wijdanabbas6583
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شكرا لحضرتك
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عظيم
@samarestephan2485
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في رقم وتس اب للتواصل
@dr.ebrahimgomaaabdelkader5401
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جزاك الله خير د. إبراهيم. Evidence exists that both drugs (methimazole and PTU) can be given as a single daily dose. (Pharmacotherapy Handbook 2021)
@dr.ebrahimgomaaabdelkader5401
2 жыл бұрын
Propylthiouracil: Drug information Dosing: Adult Hyperthyroidism: Oral: Initial: 300 mg daily in 3 equally divided doses (~8-hour intervals); 400 mg daily in patients with severe hyperthyroidism and/or very large goiters; an occasional patient will require 600 to 900 mg daily; usual maintenance: 100 to 150 mg daily in 3 equally divided doses Adjust dosage as required to achieve and maintain serum T3, T4, and TSH levels in the normal range. An elevated T3 may be the sole indicator of inadequate treatment. An elevated TSH indicates excessive antithyroid treatment. Hyperthyroidism associated with Graves’ disease (off-label) (Ross 2016): Oral: Initial: 50 to 150 mg (depending on severity) 3 times daily to restore euthyroidism; as clinical condition improves, may reduce dosage to usual maintenance dose of 50 mg 2 to 3 times daily for a total of ~12 to 18 months then discontinue if thyroid function tests (eg, TSH, thyrotropin receptor antibody [TRAb]) are normal at that time. Thyrotoxic crisis/thyroid storm (off-label use): Oral: Note: Recommendations vary widely and have not been evaluated in comparative trials. The American Thyroid Association recommends a loading dose of 500 to 1,000 mg followed by 250 mg every 4 hours (Ross 2016). As thyrotoxicosis improves, a gradual dose reduction to a dose within the standard maintenance ranges is recommended (Goldberg 2003). Dosage adjustment for concomitant therapy: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.
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