This episode discusses in an accessible conversational way the major misunderstanding about Retin-A.
Large doses of vitamin A do not build collagen in the long run.
Rather large doses of vitamin A provoke the skin into an unnatural “crazy” phase where there is a TEMPORARY increase in collagen that later completely disappears.
Unfortunately, the skin does not return to “normal” with continued Retin-A use.
It gets thinner. Both the epidermis and the dermis.
This episode is the first time that we’ve discussed the role of Retin-A in suppressing new fat cell formation, a process known as adipogenesis, that is critical to maintaining your skin health - and your appearance.
Retin-A affects adipogenesis in 2 ways. Direct inhibition and by inducing inflammation.
This has been shown - contrary to the uninformed opinion of Dr. Dray - in vitro, in vivo, and in humans.
The links to the 2 studies by Richard Gallo’s group are here:
Antimicrobial production by perifollicular dermal preadipocytes is essential to the pathophysiology of acne - PubMed (nih.gov)
Retinoids Enhance the Expression of Cathelicidin Antimicrobial Peptide during Reactive Dermal Adipogenesis - PubMed (nih.gov)
Chapter 1. Does Retin-A thin the skin?
Chapter 2. Doesn't Retin-A build collagen? (2:20)
Chapter 3. Does Retin-A affect the skin's fat cells (4:13)
Chapter 4: The amazing TRET before afters explained (7:03)
Chapter 5: Increased cell turnover benefits? (9:23)
Chapter 6: Using skincare as needed, a digression (10:55)
Chapter 7: Why derms are not telling you the truth, a hypothesis (12:22)
For a more detailed discussion and to find the references, please see:
How Retin-A gaslighting dumbs down skincare and encourages bullying. | by Ivan Galanin | Medium
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