Although it is never stated in the show, the main character shows all the signs, especially when he explains how he feels in a very recent episode (at the beginning of this video clip). His character is extremely interesting and without him the show would surely fail. Asperger's syndrome is an autism spectrum disorder (ASD) that is characterized by significant difficulties in social interaction and nonverbal communication, alongside restricted and repetitive patterns of behavior and interests. It differs from other autism spectrum disorders by its relative preservation of linguistic and cognitive development.
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Sheldon Has Asperger Syndrome - From "The Big Bang Theory"
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