This is the most clear and straightforward biochemistry explanation I've ever heard. I appreciate you :)
@user-gw5hs4sh4t
Жыл бұрын
Human CYPs are primarily membrane-associated proteins[20] located either in the inner membrane of mitochondria or in the endoplasmic reticulum of cells. CYPs metabolize thousands of endogenous and exogenous chemicals. Some CYPs metabolize only one (or a very few) substrates, such as CYP19 (aromatase), while others may metabolize multiple substrates. Both of these characteristics account for their central importance in medicine. Cytochrome P450 enzymes are present in most tissues of the body, and play important roles in hormone synthesis and breakdown (including estrogen and testosterone synthesis and metabolism), cholesterol synthesis, and vitamin D metabolism. Cytochrome P450 enzymes also function to metabolize potentially toxic compounds, including drugs and products of endogenous metabolism such as bilirubin, principally in the liver. The Human Genome Project has identified 57 human genes coding for the various cytochrome P450 enzymes.[21]
@dx398
Жыл бұрын
Nice explanation, are you an endocrinologist?
@Carlitoboyhey
4 жыл бұрын
Love the energy and speed. First time i kinda understood this. As a med student i'd maybe like more clinical relevance, like deficiency in 5alfareductas, anti bodies against 21-hydroxylas (addison) and their consequense. This is what makes me remember the steps (like when u involved mice with corticoids, loved that). Just ideas mb for a follow up vid.
@but1z
5 жыл бұрын
Your channel is fantastic, informative and well presented. I just self research/study topics such as these in my own time and really am enjoying your channel, keep uploading!
@CatalystUniversity
5 жыл бұрын
Thank you, and I'm glad you are able to do that with my channel. Best!
@daniellecampagnolo7718
4 жыл бұрын
Awesome video- really clear and concise articulation of the process, just self-studying and found this was incredibly helpful! Thanks! do you happen to have a transcript of what you say in the video? I'd like to be able to read your verbal descriptions of the pathway :)
@theelderlardrider2425
Жыл бұрын
if you click on the three dots next to the share button next to the like buttom it will give you an option to view the transcript
@Renatus_Eruditus
9 ай бұрын
Really concise and elucidating video! I especially like the use of this diagram. Juat one note. I believe aldosterone was later discovered to lack an aldehyde group, so its etymological "aldo" naming is incorrect. The name wasn't changed since then, but even in your diagram, it can be seen that carbon 18, double-bonded to an oxygen, is bound to another carbon - not a hydrogen. Love your videos. Thanks for all your good work!
@sanmioduntan715
2 жыл бұрын
The best explanation gotten on steroidogenesis so far, thank you.
@erector5953
2 ай бұрын
very sharp
@youssefelkrichi4064
3 жыл бұрын
Thanks man! Helping me understand my results a lot, and giving me insight in how to steer my doctor into measuring the right steroids upstream
@itsmevd9916
28 күн бұрын
Excellent ❤
@xuanningyang3645
2 жыл бұрын
Very clear, very concisely explained!
@nanawitch2478
3 жыл бұрын
Thank you 😊 this video really helped me 🤗
@LikeTheVik
3 жыл бұрын
wow best explanation ever. ty!!!!
@user-wk2zh5yz5r
4 жыл бұрын
A great video and very clear explanations. Why are the pathways called delta-4 and delta-5? Thanks
@yaelbruk4578
Жыл бұрын
It is because of where the double bond it. Delta signifies a double bond and the pathways with delta in the name "move" the double bond
@LuisHerrera-ji2hn
Жыл бұрын
Awesome video, thank you!
@minamimyouikyung8609
6 ай бұрын
That was AMAZIIIINGGGGGGGG🤩🤩🤩
@aishwaryapatil5621
3 жыл бұрын
Thanks a lot, this helped me😇
@MubashraZahoor
2 жыл бұрын
Can you please send first slide it's not so clear
@beefycurry
2 жыл бұрын
Awesome video. Curious to get your thoughts. What would make someone not be able to convert cholesterol into these hormones? I have lots of cholesterol but can't convert it.
@cg1811
Жыл бұрын
Did you ever get an answer to your question? I seemed to be having the same issue
@36nibs
3 жыл бұрын
This guys name is toke-off like a smoking contest🤣😭😆😂
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