This immunology lecture explains about the types of T cells involved in the development of cell mediated immunity including the role of T helper cell and cytotoxic T cells.
T cells have evolved to protect us against intracellular microbes (viruses and some bacteria) and to help B cell responses. The specific T cell antigen receptor (TCR) recognizes protein antigens that have been processed into peptides and bound to MHC molecules. Helper (CD4+) T cells recognize peptide antigens in MHC class II molecules on dendritic cells, macrophages and B cells. Cytotoxic (CD8+ ) T cells recognize peptides in MHC class I molecules. The T cell
repertoire is generated and selected for survival in the thymus. Recognition of the peptide antigen by the TCR results in signaling leading to transcription of genes encoding cytokines and their receptors, e.g. IL-2, required for clonal expansion of specific T cells. Effector molecules such as IFNγ for activating macrophages are produced by Th1 cells. IL-4 is produced by Th2 cells and is important for B cell proliferation.
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Thank you for watching the video on T helper cell and Cytotoxic T cell and their role in cellular immunity.
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