In the long run, mutation is the key to evolution, but in the short run, it's not exactly your health's best friend. Here's how genomic instability messes with your body and contributes to aging.
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Sources:
Genomic instability in the Hallmarks paper:
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013). The hallmarks of aging. Cell, 153(6), 1194-1217.
DNA repair efficiency declines with age:
Gorbunova, V., Seluanov, A., Mao, Z., & Hine, C. (2007). Changes in DNA repair during aging. Nucleic acids research, 35(22), 7466-7474.
NMN reduces aging symptoms in mice:
Rajman, L., Chwalek, K., & Sinclair, D. A. (2018). Therapeutic potential of NAD-boosting molecules: the in vivo evidence. Cell metabolism, 27(3), 529-547.
NMN reduces DNA damage:
Li, J., Bonkowski, M. S., Moniot, S., Zhang, D., Hubbard, B. P., Ling, A. J., ... & Aravind, L. (2017). A conserved NAD+ binding pocket that regulates protein-protein interactions during aging. Science, 355(6331), 1312-1317.
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#Biology #Aging #Genetics #DNA #DNAMutations #HallmarksOfAging #LifeExtension #NMN #Genome #GenomicInstability
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