Welcome to an exploration of long COVID, a medical mystery that has emerged from the shadows of the global pandemic to challenge our understanding of post-viral syndromes.
In this video, Dr Sanil Rege will shed light on the heterogeneous nature of this condition. We draw parallels with historical medical challenges like syphilis, lupus, and anti-phospholipid syndrome, aiming to demystify the various pathophysiological processes and multi-organ involvement.
Deep diving into long COVID symptoms, we address the profound fatigue, 'brain fog,' and the debilitating post-exercise symptom exacerbation reminiscent of PEM in chronic fatigue syndrome.
We explore the physical manifestations, from dyspnea and chest pain to generalised pain, which may evolve into chronic conditions.
Our focus then shifts to the brain's important role in mediating these symptoms.
We discuss the pathophysiology underlying fatigue and brain fog, examining the involvement of the glymphatic system, cerebral hypometabolism, direct viral effects on muscles, and neurotransmitter imbalances that contribute to a cascade of physiological disturbances.
The video highlights the importance of recognising the glymphatic system's function in waste clearance during deep sleep and how insomnia, a core feature of long COVID, can severely impair this process.
We delve into the heightened noradrenergic tone and propose strategies to improve glymphatic clearance and mitigate these effects.
The intricate role of inflammation in reducing dopamine levels and its impact on the frontal cortex and limbic system is also examined.
Understanding the susceptibility of individuals with ADHD to long-term COVID-19, the gender-based risk factors, and the implications of amygdala hypersensitivity is crucial in developing targeted therapeutic interventions.
We explore the autonomic nervous system's response, the gut-brain axis, and the role of the vagal system in inflammation and its effects on the brain.
We tackle the complex interplay between the neurocircuitry of pain, the autonomic nervous system, and the brain's interoceptive pathways, which amplify symptoms.
We challenge viewers to think outside the box, to question the efficacy of single-agent therapies, and to consider the broader spectrum of hyperarousal, sleep disturbances, pain, and muscle activation.
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For more resources, visit the link in the description.
Key Moments:
0:00 What is Long Covid?
4:06 The Range of Long Covid Symptoms
9:32 Role of Inflammation and its Impact on Dopamine and The Brain
10:33 The link between ADHD, Long Covid and Chronic Fatigue Syndrome
12:28 Long Covid, Hyperarousal and Sleep
13:27 Autonomic nervous system dysfunction, POTS and its impact on Long Covid symptoms.
15:49 Principles of Managing POTS
18:00 Managing long COVID symptoms through a multi-pronged approach.
19:36 Mast Cell Activation and Long Covid
#LongCOVID #PostViralSyndrome
#BrainBodyConnection
#Neuropsychiatry
#COVID19Recovery
#ChronicFatigue
#BrainFog
#COVIDNeuroscience
#InflammationAndDisease
#SleepAndImmunity
#POTS
#AutonomicNervousSystem
#ViralAftereffects
#COVIDLongHaulers
#GlymphaticSystem
#Neuroinflammation
#MedicalEducation
Relevant Resources:
CFS / ME / Long Covid Masterclass 👉psychsceneacademy.com/#/curri...
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