Heparin is a naturally occurring oligosaccharide polymer
Heparin acts as an anticoagulant
Upon binding to the natural anticoagulant antithrombin, heparin greatly increases the activity of antithrombin....thus speeding up the process of thrombin inactivation.
Interestingly, it slows the coagulation primarily by binding to both thrombin and Factor Xa in approximately equal proportions.
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why do we monitor heparin level
Its because the patient response to a given dose is highly variable
Currently, the Activated Partial Thromboplastin Time (aPTT) is the laboratory test most commonly used to monitor
Clinicians target a heparin dosage that provides an aPTT of 1.5 to 2.5 of a normal control value within 24 hours of start of therapy.
Sub-therapeutic heparin levels during these first 24 hours are associated with a high incidence of venous thromboembolism (VTE) recurrence.
Too high a dose of heparin may lead to uncontrolled bleeding and hemorrhage;
Негізгі бет Therapeutic Heparin Monitoring | Heparin APTT Monitoring | Anti-Xa Assay For Heparin Monitoring |
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