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Unit 03 of Medicinal Chemistry 03 contains following topics-
Anti-tubercular Agents
Synthetic anti tubercular agents: Isoniozid*, Ethionamide, Ethambutol,Pyrazinamide, Para amino salicylic acid.*
Anti tubercular antibiotics: Rifampicin, Rifabutin, CycloserineStreptomycine, Capreomycin sulphate.
Urinary tract anti-infective agents
Quinolones: SAR of quinolones, Nalidixic Acid,Norfloxacin, Enoxacin, Ciprofloxacin*, Ofloxacin, Lomefloxacin, Sparfloxacin, Gatifloxacin, Moxifloxacin
Miscellaneous: Furazolidine, Nitrofurantoin*, Methanamine.
Antiviral agents:
Amantadine hydrochloride, Rimantadine hydrochloride, Idoxuridine trifluoride, Acyclovir*, Gancyclovir, Zidovudine, Didanosine, Zalcitabine, Lamivudine, Loviride, Delavirding, Ribavirin, Saquinavir, Indinavir, Ritonavir.
Antiviral drugs are a class of medication used for treating viral infections. Most antivirals target specific viruses, while a broad-spectrum antiviral is effective against a wide range of viruses. Unlike most antibiotics, antiviral drugs do not destroy their target pathogen; instead, they inhibit their development.
Different methods of classification for antiviral drugs -
(1)- According to their effect on virus replication stages-
Examples- (A) Viral attachment and entry (B) Uncoating of virus (C) Transcription of virus (D) Translation of virus (E) Nucleic Acid synthesis in Virus either- DNA or RNA (F) Replication of virus (G) Assembly of Virus (H) Budding and release of the virus
(2) According to the mechanism of action and site of action of antiviral drugs
(A) DNA polymerase inhibitors (B) mRNA synthesis Inhibitors (C) Inhibitors of viral penetration and Uncoating (D) Neuroamidase inhibitors (E) Immunomodulators (F) Antiretroviral Drugs
(3) According to clinical conditions
(A) herpes viral infection (B) Cytomegalovirus infection (C) Anti-influenza virus (D) Anti-retro virus (E) Drugs for hepatitis- B and C
Acyclovir is in a class of antiviral medications called synthetic nucleoside analogues. It works by stopping the spread of the herpes virus in the body. Acyclovir triphosphate competitively inhibits viral DNA polymerase by acting as an analog to deoxyguanosine triphosphate (dGTP). Incorporation of acyclovir triphosphate into DNA results in chain termination since the absence of a 3' hydroxyl group prevents the attachment of additional nucleosides.
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Негізгі бет Topic (44) Antiviral Drugs | Acyclovir = Mechanism of Action | Acyclovir Mechanism of Action | Virus
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