0:00 - Introduction
02:16- How are BRCA 1 and BRCA2 genes related to breast and ovarian cancers?
04:56- Inheritance of defective BRCA genes
06:31- Why do BRCA related cancers have a high rate of recurrence?
12:54- Ongoing research and new treatment modalities for BRCA related cancers
15:17- What are the specific groups with a high percentage of BRCA1 and BRCA2 mutations?
17:44- Advice for patients having a genetic predisposition for breast and ovarian cancers.
20:59- Role of PALB2 OR BRCA3 gene in breast and ovarian cancers.
22:53- How often should people get re-tested after a negative BRCA mutation test?
The BRCA1 (BReast CAncer gene 1) and BRCA2 are genes that produce proteins crucial for DNA repair. Since these proteins play a pivotal role in cellular resilience against DNA damage - mutations leading to inactivation of these genes results in increased vulnerability to cancers. Women with inactivating mutations in BRCA genes face elevated lifetime risks of recurrent breast and ovarian cancers, often having to undergo vigilant monitoring with some having to opt for preventive surgeries to remove their breasts and ovaries to reduce cancer risks. Despite advancements in understanding the initial cancer development, the factors driving recurrence of BRCA related breast and ovarian cancers remain elusive, posing a significant challenge in managing the long-term health of mutation carriers. We are talking to Dr. Katherine L. Nathanson of the University of Pennsylvania to understand more about the complexities of BRCA related breast & ovarian cancers and gain insights into ongoing research and the potential avenues for future breakthroughs.
This talk has been created by CureTalks.com, in association with University of Pennsylvania to facilitate discussions for solutions, with a mission to heal the world through information and sharing of knowledge. At CureTalks we discuss groundbreaking medical research including a wide range of medical, health, and wellness issues, bringing together the doctors, researchers and patients on the same platform.
#breastcancer #brca #ovariancancer
Негізгі бет Unraveling the Complexities of BRCA-Related Breast and Ovarian Cancers
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