I just started taking this about 8 days ago. Never noticed anything until today and holy smokes, is there a difference. All day I've been asking myself why I am so calm and content. Just overall feeling positive.
@thejdocrealminute4648
3 жыл бұрын
Awesome! Job well done!!
@summerann942
3 жыл бұрын
this gives me so much hope! im just starting SAMe :)
@cindyski4413
3 жыл бұрын
Thanks for the hope!
@hkondabeatz8203
2 жыл бұрын
Jesus Christ is our only hope amen
@Eserr7856
Жыл бұрын
How are you feeling now? For the past year?
@seanmaher2987
3 жыл бұрын
Hi guys - just for those who might not know, SAM-e is best taken with vitamins B12, B9 and B6. Be sure to take a good B complex with these forms included. If you're unsure of my advice, please look into it yourself as I understand they are necessary co-factors for proper efficacy of SAM-e. Also ensure you are taking 'enteric coated' SAM-e.
@DarkAngel-cj6sx
2 жыл бұрын
You are right, you can have a heart attack if you don't take it as you mentioned
@jamesalles139
Жыл бұрын
yes - make that B9 as Folate
@light_angel.23
Жыл бұрын
Anyone know if SAM-e can replace antidepressants? I can’t their side effects
@light_angel.23
Жыл бұрын
Anyone know if SAM-e can replace antidepressants? I can’t their side effects
@TupacDatBtch
Жыл бұрын
Can I just take SAMe and B Complex together. And not take b12 or foliate
@SchecterMongoose
3 жыл бұрын
0:14 He's thinking "Meh, f*** that intro".
@CernelKorn
3 жыл бұрын
😂😂😭
@ntwalipat2
3 жыл бұрын
That intro was gold!😂😂😂
@femmefatalexX1
3 жыл бұрын
Omg how isn’t this viral ?
@femmefatalexX1
3 жыл бұрын
Let’s makes This viral !!!!
@TzoHill
6 ай бұрын
😂😂😂😂
@googanmcboogie9307
Жыл бұрын
It was recommended for me to take this with St. John's Wort to help with my combat related PTSD. I'm trying not to rely on pharma chemicals for balance and I can definitely tell a difference when I haven't had these in a couple days.
@sarahscott2496
7 ай бұрын
I would edit your comment to say that taking SAM-e in conjunction with St. John’s wort can cause serotonin syndrome, a life threatening condition.
@radicalhonesty3628
2 жыл бұрын
I don't know how to change my life around... I watch this video and what arises in me is overwhelm and stress. my dream life feels 999-trillion universes away from my reality: - I have minimal work (I live in poverty) - the place I rent is old-old and teeny-teeny tiny-tiny - I have passions and talents that could make me rich, but... - I'm single, have been my whole life, I die for true love - fat and diabetic - old now, no longer attractive - no friends - always a million-trillion stressful things to do...
@beingbenign2685
7 ай бұрын
Did you try SAMe?
@Bazza5000
3 жыл бұрын
I have heard that it is good to have L-Methyfolate with Sam-E along with certain B vitamins. This could help with depression. Of course, dealing with leaky gut, if you have it, is important to help with vitamin absorption.
@mobscene111
4 жыл бұрын
Apparently this suppose to have really postive effects for treating the symptoms of depersonalization but some people reckon the effects wear off because the body builds up a tolerance to it
@cybersal7
2 жыл бұрын
I suffer from alopecia all over and when I worried about my looks I tried this for my fibromyalgia and I actually grew eyelashes. It got too expensive but I really wish I could take it again. Only two brands worked for me.
@SunnyBunney
Жыл бұрын
Which 2 brands?
@leeyost9917
Жыл бұрын
@@SunnyBunneydra best and 400mg and either life extension or narrow I forget the other good one drs best
@NowAbundant
Жыл бұрын
Jarrows
@thepartyfairyllc7678
2 жыл бұрын
Thanks doc, 28 years old was diagnosed with lupus earlier this year: dealing with multiple health issues, started this supplement earlier this week
@thejdocrealminute4648
2 жыл бұрын
Include Vitamin D3
@thepartyfairyllc7678
2 жыл бұрын
@@thejdocrealminute4648 thanks doc! I’ll keep watching your videos!
@lttrhd
2 жыл бұрын
Get plasmapheresis
@marmararraj76
Жыл бұрын
This stuff is a god send. ❤
@deeliciousgrapes
4 жыл бұрын
Phenomenal must be his favorite word lol! Great video. My dad suggested SAMe to me for depression and bone health and ordered me some. I hope it works.
@thejdocrealminute4648
4 жыл бұрын
Thank you for your comment & support. Please keep us updated.
@bouss2382
4 жыл бұрын
Did it work for you?
@karleeonnamarae6435
3 жыл бұрын
I’ve been scared to take this for some reason, but just started a few days ago, thank you for this information!
@thejdocrealminute4648
3 жыл бұрын
You got this!
@playboybarbie9853
3 жыл бұрын
Hi, how is it working for you? I tried it once & liked it but never repurchased. I had a loss & need something natural to help me thru it. What brand did you pick up? Thanks!
@mjade1673
3 жыл бұрын
Yes me too! Ppl have been telling me since 1999 to take this and i🤦🏻♀️ was too scared😅. Im taking it now... its freakin awesome!! Once a week seems enough for now😇💪
@cindyski4413
2 жыл бұрын
I’m slob or just so sluggish. I tried this and felt great. Had to know more about it.
@thejdocrealminute4648
2 жыл бұрын
Thank you for your comment.
@carolinarodriguez1792
3 жыл бұрын
Ok Im in, Day 1 , I don't like taking pills. Any thing all natural is fine. I was scared too to take it . But Dr. Jawad was the only Video that set my mind at ease. Thank you , Ill be back
@thejdocrealminute4648
3 жыл бұрын
Thank you for your support.
@ryanscanlan9875
4 жыл бұрын
SAME-e is VERY effective and I find it actually far better than Pharma grade anti-dep. But it does wear off, especially with a high dose. 1, maybe 1.5 months and it does noting for me. I also had to wait many months to get any receptors back in order to get an effect again. So amazing for 1 or 2 months a year for high dose.
@NAT-turners-Revenge
9 ай бұрын
Dude, I felt suicidal on this stuff
@DynamicChris18
3 жыл бұрын
I’m going to start taking this for my headaches instead of taking elavil. I’m 26 I don’t need an anti depressive.
@mrr7885
4 жыл бұрын
Hello, will SAM-e effect the healing of my dopamine receptors etc? I’m currently experiencing withdrawal symptoms (anxiety, depression, headache, trouble concentrating, memory problems) from quitting a very bad habit.
@thejdocrealminute4648
4 жыл бұрын
Give it time.
@Malitubee
3 жыл бұрын
I’m quitting that same very bad habit myself man , stay strong . As far as the research says it won’t effect it
@Mamarita3333
2 жыл бұрын
Great videos always! Thank you!!!!!! 🙌🏼
@thejdocrealminute4648
2 жыл бұрын
You are so welcome!
@richardhentworth5612
3 жыл бұрын
I loved it. it makes you so positive and you feel the difference after a few days for a few weeks before it becomes normal... I just cant find any locally and it is so expensive. Some supps are in the fridge - is this important?
@thejdocrealminute4648
3 жыл бұрын
I keep some supplements in the fridge as well.
@danielhendrix8397
3 жыл бұрын
You can buy l-methionine instead - much cheaper, just not as strong. SAMe is S-adenosyl methionine
@henchoakes8016
3 жыл бұрын
Great video. I started taking this 3 weeks ago for depression - I've noticed a real difference. I started on 200mg and now up to 600mg! So I take for 60 days then how long do I need to stop taking it for ? Thank you
@thejdocrealminute4648
3 жыл бұрын
I recommend doing 90 days on 30 days off.
@MistsOfRaine
2 жыл бұрын
Can you take this with L-theanine, ashwaghanda or valerian root? I take L- theanine and want to make sure there’s no interaction! Thank you
@1785Kristy
4 жыл бұрын
So why do you recommend cycling 60 days on and off SAMe? I tried it years ago. Decided to try it again for constant aches and pains and feeling really down for a while now. Working for my pain so far pretty well.
@thejdocrealminute4648
4 жыл бұрын
I always recommend coming off supplements for a while to reset the receptors.
@Bazza5000
3 жыл бұрын
@@thejdocrealminute4648 How long is a while, Dr. Jawad? Two weeks?
@winterpaws01
Жыл бұрын
I am taking 5HTP and Tyrosine but would like to use SAM-e for liver health. Is this OK and not sure what time of day was loosely thinking tyrosine on rising, sam-e at mid morning, tyrosine a bit before lunch and then 5 htp in afternoon. Really interested in your thoughts having just found your channel
@thejdocrealminute4648
Жыл бұрын
Compounds that Affect the Brain: Use caution when combining 5-HTP with other medications or supplements that affect amino acid production, like carbidopa, St John's wort, and SAM-e. Combining these supplements may cause anxiety, rapid speech, or other serious side effects.
@wille7319
4 жыл бұрын
Excellent video. One question: I've read Sam-E is to be taken on a empty stomach. Since you said to divide the doses. When is the second best time to take it besides as soon as you wake up on an empty stomach?
@thejdocrealminute4648
4 жыл бұрын
You can take it in between meals...
@Frank-jb2hi
5 жыл бұрын
Hi jdoc. Thanks for the informative video. I don't presently take SAMe but I've long wondered about it.
@thejdocrealminute4648
3 жыл бұрын
It is good stuff to take.
@arunjain475
3 жыл бұрын
Hi i am diagnosed with fatty liver grade 2 i visited 2 doctors one recommended ursocol and other cirrosam 400 which one i take my SGPT is 74 and conjugated bilrubin is 0.22…
@gif24gt60
4 ай бұрын
Is it safe long term??
@Butterflylovely5
3 жыл бұрын
Sam-e is for methylation that’s it’s job, if you have certain genetics 🧬 you don’t methylate and you need same but same is but for everyone even if you have the symptoms he mention, so before you take it make sure to test your genes!!
@fadisalem5961
5 жыл бұрын
Great video doc as always very informative so ty for that. Anyways I have an irrelevant question according to this video tho; Can pork be a healthy kind of food to be consuming as long as it's organic and free-range?
@thejdocrealminute4648
5 жыл бұрын
You are always welcome. Thank you for being a fan of mine. Yes --- that is fine.
@fadisalem5961
5 жыл бұрын
@@thejdocrealminute4648 my pleasure doc and a HaPpY EaStEr to you as well.
@dena_healed69
2 жыл бұрын
I love this stuff! I stopped taking Celexa about a year ago bc it stopped working. SAM e works. I’m happy with it
@thejdocrealminute4648
2 жыл бұрын
Good to hear that you are getting better.
@vedatzorro
Жыл бұрын
Thank you for good information
@thejdocrealminute4648
Жыл бұрын
You are welcome.
@TheRetrospective
4 жыл бұрын
Great video, thanks. Do you have a rough SAMe dosage range for heavy-metal exposure?
@thejdocrealminute4648
4 жыл бұрын
Oral dosages of 1600 mg/day of SAMe appear to be significantly bioavailable and nontoxic, at least regarding toxic methylated metabolites and homocysteine. However, the risk of mania in vulnerable individuals remains a serious concern. That would be the MAX dosage to take.
@niliw72
3 жыл бұрын
Hi, can SAMe be taken with l theanine and bacopa all together?
@jcresmond1653
2 жыл бұрын
I subbed. Great fast info. Great video
@thejdocrealminute4648
2 жыл бұрын
Thanks for the sub!
@serious-cyrusnoelan8127
2 ай бұрын
Can samE become mentally dependant? Can you go through any type of ‘withdrawal’ from taking it? Please let me know if you can. I really like to be cautious about building dependency to any supplements. Thank you for this helpful video!
@przemeks577
4 жыл бұрын
Good supplement but expensive as fawk...
@rumble5557
4 жыл бұрын
Lol, Where the heck you ordering it from? On Amazon it just ranges between 15 up to maybe $40. That's it. It looks like the brand nature's trove has the highest reviews and an amazing process.
@s.w_8876
2 ай бұрын
I tried this and I started developing bumps like mole bumps under my eyes on my cheeks. Why is that. Is it because of my liver or kidneys due to the meridians below the eye?
@electrickitt3n
2 жыл бұрын
Hi! I wanted to speak with you about Sam -E as I've been taking this supplement daily for about 5 years now, however I used to take more and it would cause my speech to skip just like yours does in this video. I cut my dosage and it's been great until now, I've started to notice my speech is skipping, I'm not able to articulate as well and I'm currently holding back to see if it's the Sam -E again. Please let me know if you take this supplement as well, because my speech has been skipping and I've been replacing words just like you accidently do in the video.
@thejdocrealminute4648
2 жыл бұрын
Reduce the dosage or stop using it for 30 days to give your receptors a break.
@donnagarner6007
Жыл бұрын
Perhaps that's why he said: 60 days on, 60 days off.(?) I sure wouldn't want to add another problem!
@hmsd9597
3 жыл бұрын
Great and compact information. Question: What about the necessity to supplement Vit B6/Vit B9 and Folat (not Folat acid) to avoid having little to no benefits or even problems? Could you please clarify this point?
@thejdocrealminute4648
3 жыл бұрын
Yes, we need these as well.
@MrIgonzalez85
3 жыл бұрын
I had a blood dest done and doctor told me to take this and alph lipoic acid can I take both on a empty stomach?
@tanmaytripathi5179
2 жыл бұрын
Should I take it daily 600 mg dosage....is it safe to take for a 20 yrs old??
@angelamorris4304
2 жыл бұрын
Hi Doctor.. I have a question: Is Same the Same thing as Methione with glycine? I've hearing reports by some on KZitem that Methione cause cancer to grow. Is this true? If it is then, ,I bought the wrong product on Amazon
@thejdocrealminute4648
2 жыл бұрын
S-Adenosyl-L-methionine (also called S-adenosyl methionine, S-adenosylmethionine, SAMe, or SAM-e in the United States or ademetionine in Europe, and also often abbreviated as SAM and AdoMet) is a chemical that is found naturally in the body. Methionine is an essential amino acid, abundant in eggs, seafood, and meat. Glycine is a non-essential amino acid found in high amounts in skin, connective tissue, ligaments, tendons, cartilage, and bones.
@kubson980
2 жыл бұрын
Hey doc, i have gastritis, ibs, overall stomach pain, my depression is killin me, my emotions ruins my digestive, do u recomenned this suplemment for me? Or this can make worse my stomach symptomps?
@thejdocrealminute4648
2 жыл бұрын
Have it looked at first. That is a general question.....
@TheWinners725
4 жыл бұрын
Hello Doctor great video. Can a person add SAME to their daily intake if they are moderately alcohol drinkers? I just liked and subscribed to your channel.
@thejdocrealminute4648
4 жыл бұрын
Yes. You can. Thank you for your support.
@zackmartin00
Жыл бұрын
Lol at not editing your intro. That's how I feel when I make videos too man.
@thejdocrealminute4648
Жыл бұрын
Tell me about it. Sometimes I get tongue tied.
@light_angel.23
Жыл бұрын
Currently taking Duloxetine for anxiety. Can SAM-e potentially be taken as a natural replacement to antidepressants? Can’t stand the side effects of Duloxetine. Fatigue and Headaches are the reason
@thejdocrealminute4648
Жыл бұрын
Yes----and No----all depends on which research you have done. I read BOTH reports. You can take a chance and see how you feel..
@cindyski4413
3 жыл бұрын
Ty!!!!
@Grewal2005
3 жыл бұрын
Thanks for this information🙏 I have fibromyalgia Can you please recommend that dose
@thejdocrealminute4648
3 жыл бұрын
Fibro --- first ---> diet. Stay away from Gluten, Wheat, Dairy, Soy, and Sugar.
@Caribe78
2 ай бұрын
fibro is emotional i have healed patients
@vedatzorro
Жыл бұрын
Instead of directly taking Sam-e supplement, to take b12 methylcobalamin and methylfolate is better for methylation and depression. Is it right or not?
@Mutemadiyen-hz3uv
Ай бұрын
Aynı şey işte
@maaikewilhelmina1457
3 жыл бұрын
Thank you! I have comt ++ how much should I take and also cycle after a while??
@thejdocrealminute4648
3 жыл бұрын
Depression: 200 to 1,600 mg/day. Liver disease: 800 to 1,000 mg/day. Osteoarthritis: 1,200 mg/day initially; then maintenance 400 mg/day in some studies.
@maaikewilhelmina1457
3 жыл бұрын
@@thejdocrealminute4648 thank you very much!
@bigapple6014
4 жыл бұрын
Hello Doctor I'm currently on Buspar for anxiety disorder. Is there any natural remedies for dealing with anxiety disorder? Thank you
@thejdocrealminute4648
4 жыл бұрын
How long have you been on Buspar? Have you spoken with your Doctor about other alternatives?
@bigapple6014
4 жыл бұрын
@@thejdocrealminute4648 No I have not. I've been taking it for 2 to 3 months now. Was just looking for natural alternatives thanks.
@thejdocrealminute4648
4 жыл бұрын
@@bigapple6014 I would recommend talking with your Primary Doctor first about alternatives.
@ashrafa6903
Жыл бұрын
Thank you for the video , so can we say that SAMe is the safe replacement for 5htp and l-tyrosine? because in another video you said 5htp alone will decrease the domain, if SAMe increases both then it's better, is that true?
@thejdocrealminute4648
Жыл бұрын
'decrease the domain'?
@ashrafa6903
Жыл бұрын
@@thejdocrealminute4648 Sorry it was a typo, I mean dopamine,
@thejdocrealminute4648
Жыл бұрын
@@ashrafa6903 SAMe is a safe way to go to stabilize Dopa/Sero pathway.
@DarkAngel-cj6sx
Жыл бұрын
Hi Dr, Do you know why SAMe helped my son with sensory issues and defiance behavior?
@thejdocrealminute4648
Жыл бұрын
Why?
@BrokennessAndBeauty
2 жыл бұрын
Do you know if you can build a tolerance to Sam-e?
@thejdocrealminute4648
2 жыл бұрын
I recommend once the bottle is empty ---wait 2 weeks to reorder. Or take a few days off during the week.
@niethelemaal1007
3 жыл бұрын
How long does it take to work in your Brain and body?
@thejdocrealminute4648
3 жыл бұрын
All depends on the individual.
@niethelemaal1007
3 жыл бұрын
@@thejdocrealminute4648 Understood, thanks for your quick reaction
@innaalexeyeva4590
Жыл бұрын
does it cause anxiety and insomnia in the beginning? and does it go away after a while?
@thejdocrealminute4648
Жыл бұрын
It may. Be sure you take this in the morning. Do NOT take this at night.
@PP-hn2rq
5 жыл бұрын
Great video Doctor!Whats the best dosage for start and when build up if is necessary?
@thejdocrealminute4648
5 жыл бұрын
There is no established ideal dose of SAM-e. For depression, many studies have used between 800 -1,600 milligrams daily. For osteoarthritis, 600-1,200 milligrams daily of SAM-e divided into three doses is common. Ask your doctor for advice. Sometimes, the dose of SAM-e is increased gradually over a few weeks. This can help reduce side effects such as restlessness or anxiety.
@PP-hn2rq
5 жыл бұрын
Thanks for replay Doctor!I had read that should take with empty stomach.Is that safe?
@thejdocrealminute4648
5 жыл бұрын
@@PP-hn2rq SAMe is best absorbed on an empty stomach, so try to take it about one hour before or two hours after meals. If nausea or heartburn develop, take it with plenty of water.
@PP-hn2rq
5 жыл бұрын
Thanks Doctor!Have a great day!!
@PP-hn2rq
5 жыл бұрын
Doctor,when must increase the dose.For example if anyone use it for depression and start with 400mg then when increase dose?When be understand that the 400mg its not enough?
@JM-pv8vt
4 жыл бұрын
Do you take sam-e yourself?
@thejdocrealminute4648
4 жыл бұрын
Yes I do.
@juancardenas7101
16 күн бұрын
I want to take it cause i got of my anti psychotic for depression
@joegeorge141
3 жыл бұрын
Hello.....will this heal the serotonin receptors damaged by amphetamine use....just a doubt
@thejdocrealminute4648
3 жыл бұрын
It should. However, time needs to reset the receptors.
@juliealston1417
4 ай бұрын
If you cycle on and cycle off for 60 days- what do you do for the 60 days off?
@silkychannel7100
2 жыл бұрын
Hello doctor! I m suffering from ulcerative colitis for last 13 years& feels very depresseed due to this diseease can i take Sam e
@thejdocrealminute4648
2 жыл бұрын
Have you seen a specialist? Have you fixed your diet?
@silkychannel7100
2 жыл бұрын
@@thejdocrealminute4648 yes dr i m taking mesacol1.2 od. &. Do Not taking milk products
@thejdocrealminute4648
2 жыл бұрын
@@silkychannel7100 That is all you are taking? how can you have this for 13 years and NOT corrected it? Have you done your research?
@marywolfe6598
3 жыл бұрын
If you take it for fibromyalgia do you take it regularly or start and stop?
@thejdocrealminute4648
3 жыл бұрын
Yes, you can take it if you have fibromyalgia.
@tjgrafiks
3 жыл бұрын
just started taking mine yesterday from nature’s trove. Will this help with RA? I’ve just been diagnosed back in November. It all suddenly started in August. Came home one day n BAM joint pains started and it’s been going downhill fast affecting muscles nerves organs...EVERYTHING! I feel it’s covid related but all my tests were negative. Most pain I’ve ever felt in my life from my toes to my brain and I wouldn’t wish this on my worst enemy. I’ve lost countless nights of sleep and losing weight/ muscle almost 20lbs in just around 4 months 😩 Bloodwork is saying my liver and kidney function is fine but it doesn’t feel so. Im constantly having burning pain in my liver and kidney area then followed by digestion issues. It’s even affecting my heart. Burning and sharp pains and palpitations too. I don’t like the dull burning pains, they scare me
@thejdocrealminute4648
3 жыл бұрын
Diet --- eliminate - wheat, gluten, dairy, soy, and sugar as BEST as you can. Make sure you are taking supplements to BOOST your immune system of the body. Keep us posted.
@tjgrafiks
3 жыл бұрын
@@thejdocrealminute4648 yes was already taking 2000iu of Vit D+ k2 since October 2019 found out I was deficient. Upped to 5000 ius when covid was revealed and 2000 mg vitC , zinc and quercetin etc. I’m in the process of the elimination diet now, but feels like a lot of damage has already occurred internally bcuz of the inflammation from my immune system being in overdrive. I just have lots of pain in my liver n kidney area. The burning in muscles and these thousands of tiny nodules forming under my skin/in my tissues. They feel so gross and they hurt sometimes. My body seems to have stop or greatly slowed in absorbing nutrients and even exercise causes more pain in my joints and muscles either later that night or the following morning. It’s crazy. My body’s systems ar completely out of control
@beingbenign2685
7 ай бұрын
Jeez, your symptoms sound so horrific. I wonder if your feeling any better 3 years later?
@tjgrafiks
7 ай бұрын
@@beingbenign2685yes doing much better no thanks to western medicine doctors. I’ve lost faith in them. they only care about making money off us and not healing us. it’s a sick care business not health care. my issues seem to be all nerve related causing improper function of my digestive / immune and nervous system. once I got pressure off those nerves everything started functioning better. I had even lost use of my arms at one point. the nerves in my neck were inflamed and causing major issues. once i got the inflammation under control i was able to heal my digestive tract which also was damaged from poor nerve function. wasn’t able to break down foods properly or absorb nutrients properly. the nerves control everything. that’s why people with diabetes start having nerve issues then it just cascades into other issues. eat healthier. cut all the processed foods n sugars. my situation however was caused by injury to my neck/spine not diet. I ate very healthy with a treat once in a while. lots of fruits,smoothies and fresh juices for the last 14 years!
@rach4990
3 жыл бұрын
Can Sam-e help with PMDD?
@davidpaul3821
Жыл бұрын
Can I take SAM-e with Citicoline and phosphatidylserine ?
@thejdocrealminute4648
Жыл бұрын
Yes -- you can.
@NAT-turners-Revenge
9 ай бұрын
I tried sam E in 2012 and I legit felt suicidal
@thejdocrealminute4648
9 ай бұрын
Oh no......then, do NOT use it.
@haidersyed6554
Жыл бұрын
Should it be taken with food or on an empty stomach?
@thejdocrealminute4648
Жыл бұрын
SAMe is best absorbed on an empty stomach, so try to take it about one hour before or two hours after meals. If nausea or heartburn develop, take it with plenty of water. To prevent insomnia, don't take SAMe late in the day. Most people report a mild energy boost with the supplement.
@carl8568
4 жыл бұрын
I'm about 10 days into supplementing with SAMe (400mg a day) and haven't noticed any difference as yet. I may have to up the dosage and play around with 800+ mg.
@thejdocrealminute4648
4 жыл бұрын
Be patient -----I recommend waiting about 6 weeks to fully notice a difference.
@carl8568
4 жыл бұрын
@@thejdocrealminute4648 Ok, thanks mate.
@karine8738
3 жыл бұрын
Did it help you please ?
@carl8568
3 жыл бұрын
@@karine8738 Maybe, i'm not sure. It was very expensive though. In my case, not worth paying that much for so little benefit. What do you want to use it for?
@karine8738
3 жыл бұрын
@@carl8568thanks 😊 I am trying tryptophan, before 5htp For depression, anxiety, insomnia, body pain 😎
@danman5857
7 ай бұрын
Anyone on here used Sam-e for insomnia ? I know that's not it's primary purpose, but just checking. If you have used Sam-e for insomnia did it help?
@thejdocrealminute4648
7 ай бұрын
SAMe has a beneficial effect on those suffering from insomnia. It plays an important role in the synthesis of melatonin, a hormone associated with sleep. Melatonin has been studied as a treatment for insomnia, delayed sleep-phase syndrome,and circadian rhythm sleep disorders.
@lorimazzola2314
3 жыл бұрын
Can you PLEASE answer this question. Lol - No one seems to address this... what can you take for the diarrhea, stomach aches that can get really bad. I tried it for 5 days and had those symptoms. Should I power through because it will go away ( body adjusting) or just stop and not bother with it. Can I take something for the diarrhea issue like pepto bismal? I was on only 200 mg.
@thejdocrealminute4648
3 жыл бұрын
Stop taking whatever is giving you diarrhea. Second, address the diarrhea issue.
@lorimazzola2314
3 жыл бұрын
@@thejdocrealminute4648 that’s the tricky part. I think it was the Jarrows 200 mg Sam E that was causing the diarrhea . I was told that the mannitol that’s used in it could be the cause. Other than that Sam E was working great.
@thejdocrealminute4648
3 жыл бұрын
@@lorimazzola2314 Or switch to a different brand.
@lorimazzola2314
3 жыл бұрын
@@thejdocrealminute4648 Thank you.. I appreciate it!
@jenniferstewart730
Жыл бұрын
It’s def the mannitol! I got the now brand that doesn’t have that and no stomach issues at all!
@gymnast81
2 жыл бұрын
Can you take this supplement while you are already on an antidepressant?
@TheFlightAttendantNextdoor
Жыл бұрын
No, can cause mania
@DarkAngel-cj6sx
2 жыл бұрын
I am giving this to my son who has low VMA. HPHPA and cresol messed up his neurotransmitters. He also has HVA/VMA ratio that is high and I am using B6 to manage it Will be back for a review after another OAT test. Is this reversible?
@thejdocrealminute4648
Жыл бұрын
Only time will tell. Unless you get him tested for the Aromatic L-Amino Acid Decarboxylase Enzyme test?
@DarkAngel-cj6sx
Жыл бұрын
@@thejdocrealminute4648 no I never heard about this. However, I was told to test his DBH enzyme because I can't seem to find a lab that does it. Hopefully this enzyme has not been inactivated by clostridia. Thank you so much I will do this test
@thejdocrealminute4648
Жыл бұрын
@@DarkAngel-cj6sx Lab Corp does. In addition, the Catecholamines: Fractioned, Plasma test.
@DarkAngel-cj6sx
Жыл бұрын
@@thejdocrealminute4648 Thank you for so much. You have no idea the impact of your videos. My son regressed into onset autism at 3.5 years old last year and I was told to just find school to help him. One year now because of people like you my son is not longer aggressive, he is calm and can sleep. Now the battle is on to balance his neurotransmitters. He talked, danced and spoke two languages, loved numbers and music and now he is a shadow of himself because of clostridia. I hug you and God bless you abundantly with your family
@thejdocrealminute4648
Жыл бұрын
@@DarkAngel-cj6sx Thank you for sharing you story. Thank you for your support.
@elsewherehouse
3 жыл бұрын
Can anyone suggest any particular brands?
@dianabudzik7636
9 ай бұрын
Nature’s Trove is the best!
@mohammadmomena1527
2 жыл бұрын
Hi doc I toke sam e for about 2 weeks and it was great all depression gone and much energy. Then suddenly i become very anxious when i take , so can you help and explain what happened because i stopped it and it’s really helped me during wonderful first two weeks ( i toke without vitamin b complex could this maybe the reason )
@thejdocrealminute4648
2 жыл бұрын
Cut back on the dosage.
@mohammadmomena1527
2 жыл бұрын
@@thejdocrealminute4648 i did cut the dose from 1600 to 400 but still whenever i take it i feel so much nervous
@BrunoOliveira-sm2xi
Жыл бұрын
@@mohammadmomena1527 Maybe you are overmethylated, so Same is not ideal for you.
@NowAbundant
Жыл бұрын
Whoa, 1600mg is a lot. 200mg maybe enough for you. Also, if you are bi-polar, this supplement is not recommended.
@cindywhittaker3003
8 ай бұрын
How does this affect someone with COMT snp I am homozygous for this as well as A1298c. Thanks
@mjade1673
3 жыл бұрын
So sam-e can help if youre also not sleeping cuz insomnia..?
@thejdocrealminute4648
3 жыл бұрын
SAMe has a beneficial effect on those suffering from insomnia. It plays an important role in the synthesis of melatonin, a hormone associated with sleep.30 Melatonin has been studied as a treatment for insomnia, delayed sleep-phase syndrome,and circadian rhythm sleep disorders.31 However, production of this hormone appears to decrease with age.32 Fortunately, SAMe promotes the function of the enzyme that converts N-acetylserotonin to melatonin
@brandongordon5684
Жыл бұрын
I’ve seen many reports of adding same-e adjunct to an ssri for better efficacy . Some say it’s similar to adding Wellbutrin to an ssri . On the other hand many sat it can cause serotonin syndrome ? Any advice or experiences with this ?
@edwinvanvliet530
Жыл бұрын
Yes, i like to know this to
@thejdocrealminute4648
Жыл бұрын
Can you take SAM-e with an SSRI? SAM-e can be combined safely with other drugs since it doesn't have very many interactions. It has been combined with tricyclic antidepressants, serotonin reuptake inhibitors, and serotonin-norepinephrine reuptake inhibitors. SAM-e appears to be a very safe drug. Most of the side effects reported tend to be mild. AND---Antidepressants and other drugs and supplements that increase levels of serotonin. Don't take SAMe with antidepressants. The combination could cause effects similar to a condition caused by high levels of the chemical serotonin to accumulate in your body (serotonin syndrome). So, there are both arguments on this question.
@brandongordon5684
Жыл бұрын
Exactly , I’ve read about both sides of this argument . On the other hand I took 400 mg same natures made w/ 5 mg lexapro and it was best combo ever .
@brandongordon5684
Жыл бұрын
So basically it’s a 50/50 risk ?
@emiliegray6737
Жыл бұрын
the dog barking drove me crazy.
@thejdocrealminute4648
Жыл бұрын
It didn't bark that much..
@gabrieleisen4236
4 жыл бұрын
Is it okay to take with Adderall?
@gabriellecocucci5577
3 жыл бұрын
I take it with my Adderall, doesn’t seem to cause any problems, but do your research.
@gabrieleisen4236
4 жыл бұрын
On an empty stomach can I take Sam-e with other supplements
@thejdocrealminute4648
4 жыл бұрын
SAMe can affect a brain chemical called serotonin. ... Do not take SAMe if you are taking dextromethorphan (Robitussin DM, and others). Medications for depression (Antidepressant drugs)Interaction Rating: Major Do not take this combination
It’s supposed to be really helpful for cholestasis of the liver!
@thejdocrealminute4648
2 жыл бұрын
As well as TUDCA.
@BrokennessAndBeauty
2 жыл бұрын
@@thejdocrealminute4648 is it okay to take it for cholestasis for a long period of time to unblock the pathways while including a good diet including lots of veggies beans for methylation? I’ve been using it for a week now and my bowel movement have been PERFECT. I am suffering with fat malabsorption. Haven’t noticed anything with mood or energy. A study for alcoholics that took it for two years for there liver, no negative side effects were documented, so hoping I can use this for a while for detoxification
@thejdocrealminute4648
2 жыл бұрын
@@BrokennessAndBeauty Yes, you can take it long term.
@marywolfe6598
3 жыл бұрын
Can you take it if you are allergic to sulfur drugs?
@thejdocrealminute4648
3 жыл бұрын
Yes, you can.
@AhiyenŞerahiyen
3 жыл бұрын
Can hepatitis B patients use Sam-e? Can it improve the symptoms of the disease?
@thejdocrealminute4648
3 жыл бұрын
You can use it.
@AhiyenŞerahiyen
3 жыл бұрын
@@thejdocrealminute4648 thank you
@AhiyenŞerahiyen
3 жыл бұрын
@@thejdocrealminute4648 After using SAME, ALT values increased while GGT and AST values remained within normal limits. Is this normal?
@thejdocrealminute4648
3 жыл бұрын
@@AhiyenŞerahiyen Yes, are you on other medications?
@thejdocrealminute4648
3 жыл бұрын
@@AhiyenŞerahiyen SAMe is particularly important for the liver because it is composed of glutathione. Glutathione is vital for liver function. A significant portion of SAMe is converted to glutathione in the liver. Glutathione is the natural antioxidant of the liver.
@noeloconnor9518
9 ай бұрын
Is it good for anxiety?
@thejdocrealminute4648
9 ай бұрын
Yes..
@gymnast81
2 жыл бұрын
Can you take this while you are on Lexapro?
@thejdocrealminute4648
2 жыл бұрын
No interactions were found between Lexapro and SAMe
@MM-is7hq
4 жыл бұрын
Can hepatitis b patients use serrapeptase?
@thejdocrealminute4648
4 жыл бұрын
serrapeptase is proposed as a treatment and/or preventative for a variety of viral diseases such as AIDS and hepatitis C and B. ... As an overall remedy for inflammation, serrapeptase works to help rid your body of the cellular debris that triggers inflammation
@ArmonMitchell
4 жыл бұрын
Cut Take TWO!!!
@vickipedia3253
2 жыл бұрын
Can this help ALS patients?
@thejdocrealminute4648
2 жыл бұрын
Yes, it is good to take for ALS.
@tina4jdhsuwiue
4 жыл бұрын
can i take this if i have ocd and anxiety? (the kind of anxiety that makes you feel sick, restless and uneasy all the time)
@thejdocrealminute4648
4 жыл бұрын
Yes, you can. Include Ashwagandha as well for the anxiety.
@tina4jdhsuwiue
4 жыл бұрын
TheJDocRealMinute got it, thank you!
@GoToHow
4 жыл бұрын
Florentina Mitroi I have the same Problem Restless and Insomniac anxiety. Palpitations 24/7..Have you tried SAMe. Please update
@tina4jdhsuwiue
4 жыл бұрын
GoToHow i didn’t take it yet. i postponed it because of the pandemic and then totally forgot.
@GoToHow
4 жыл бұрын
@@tina4jdhsuwiue I am getting mine tomorrow. Let see how I feel. Mental disorders is hell😣. Specifically anxiety
@isaacmettle
2 жыл бұрын
Does S-adenosylmethionine interact with bupropion
@thejdocrealminute4648
2 жыл бұрын
No interactions were found between SAMe and Wellbutrin. This does not necessarily mean no interactions exist.
@isaacmettle
2 жыл бұрын
@@thejdocrealminute4648 actually I’m gonna be the first 2 tell u. Fortunately I got it from Amazon so I can get refund and my dosage was only 200. I know your familiar with Serotonin Syndrome. I started getting confused and had bad motor control. FORTUNATELY I was at home and didn’t have go 2 work till 12 hours later and the SAM-e was no longer in effect cause it has a small half life. It might be different 4 others though.adrafinil was a similar experience.
@Diogenes-II
5 жыл бұрын
Dr., Great and thoughtful video as always. Correct me if I'm wrong, SAMe helps speed up a sluggish methylation cycle, correct? So, by taking too much of it if your cycle is already normal can cause haywire? Also, I have read SAMe should be taken with active forms of B vitamins such as methylfolate, P5P, NADH and adenosyl-cobalamin, because it depletes said vitamins. What are your thoughts? (I take SAMe (200mg) only once per month, because it makes my right arm twitch if I take it for more than 1 day in a row.)
@thejdocrealminute4648
5 жыл бұрын
Yes -- it helps speed up the methylation cycle. Correct, by taking too much it can cause haywire. If you are producing a sufficient amount of SAMe in your body already? Yes, it may cause your body to go haywire.
@eusuntaceleusunt
4 жыл бұрын
If I take TMG and Niacin, may I take SAMe?
@thejdocrealminute4648
4 жыл бұрын
What is TMG?
@eusuntaceleusunt
4 жыл бұрын
@@thejdocrealminute4648 thimethylglycine
@thejdocrealminute4648
4 жыл бұрын
I found no research stating why you should NOT take them together.
@naturalnetural7120
5 жыл бұрын
Any side effects of s adynoselmethionine ?
@thejdocrealminute4648
5 жыл бұрын
Side effects from SAMe are rare and, if they occur, usually mild. SAMe can cause: Upset stomach Nausea Mild insomnia Dizziness Irritability Anxiety Sweating Constipation Diarrhea
@naturalnetural7120
5 жыл бұрын
TheJDocRealMinute i use it but i feel hard constipaion and depration . i have fatty liver high sgot sgpt and 1.8 bilirubine . stop the medicine i feel normal . can i take it or stop .i take 400 mg am... pm doctor prescribed me . pleas suggestion.
@thejdocrealminute4648
5 жыл бұрын
I would suggest working on to clean up your diet to focus on your fatty liver.
@scoopaway1925
2 жыл бұрын
Great video! I know anti-depressants can cause hair loss. Would Sam-e do the same?
@thejdocrealminute4648
2 жыл бұрын
It won't cause hair loss. It will actually help --- add -- CoQ10 300 mg as well.
@scoopaway1925
2 жыл бұрын
@@thejdocrealminute4648 Thank you for responding Dr.
@sammiec7285
2 жыл бұрын
Can you take SAMe with 5htp?
@thejdocrealminute4648
2 жыл бұрын
Yes, No interactions were found between 5-HTP and SAMe.
@sammiec7285
2 жыл бұрын
@@thejdocrealminute4648 thank you
@FREAK12111
3 жыл бұрын
Side effects??
@thejdocrealminute4648
3 жыл бұрын
SAMe is LIKELY SAFE when taken by mouth, given intravenously (by IV), or when injected as a shot, appropriately. It can sometimes cause gas, vomiting, diarrhea, constipation, dry mouth, headache, mild insomnia, anorexia, sweating, dizziness, and nervousness, especially at higher doses
@swinneyfuller
3 жыл бұрын
Does sam-e causes constipation?
@thejdocrealminute4648
3 жыл бұрын
High doses of oral SAM-e can cause symptoms like gas, upset stomach, diarrhea, constipation, dry mouth, headache, dizziness, anxiety, and skin rashes. SAM-e can also trigger an allergic reaction in some people
@swinneyfuller
3 жыл бұрын
@@thejdocrealminute4648 thanks for the reply if you have those symptoms stop taking it?
@notthatguyyy
2 жыл бұрын
Can you take SamE together with 5-htp, on a daily basis?
@thejdocrealminute4648
2 жыл бұрын
No interactions were found between 5-HTP and SAMe. I would not recommend taking 5 HTP for the long term. Watch my video on Dopamine and Serotonin.
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