What is Dopamine Psychosis
Many people with schizophrenia have an increased ability to produce dopamine and appear to release unusually high quantities of dopamine during nerve cell activity. We know this from PET studies that can measure dopamine synthesis in the brains of living human volunteers, and from measures of dopamine metabolites in volunteers.
This short lecture will consider the role of dopamine in producing symptoms of psychosis, and will suggest that: in the treatment of psychosis, a little bit of dopamine blocking can a useful tool; but too much dopamine blocking should be avoided.
This lecture is part of Northeast Ohio University's education(+)consultation service, SZconsult.
A PDF of this lecture is available at szconsult.org/
TIMESTAMPS
00:00 - Intro
00:15 - Objectives
00:58 - Dopamine Hypothesis
03:15 - Dopaminergic Drugs
05:02 - Dopamine pathways in brain
06:10 - How overactivity in dopamine signaling can cause psychosis
08:40 - A little fine tuning is a good thing
10:43 - Too much dopamine blocking is a very bad thing
12:07 - Dosing
13:38 - Risperidone dose occupancy curve
14:29 - Ziprasidone dose occupancy curve
14:50 - Paliperidone dose occupancy curve
15:09 - Aripiprazole dose occupancy curve
15:58 - Limitations of dopamine hypothesis
17:11 - Summary
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I’m a board-certified psychiatric physician and also have a PhD in pharmacology. I’m a consultant psychiatrist, researcher, lecturer, teacher, and solution-focused scholar currently affiliated with Northeast Ohio Medical University
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