Mesenchymal stem cells (MSCs) are multipotent stem cells that originate in mesoderm at early development. MSCs were first discovered in bone marrow and later confirmed to be isolated from a variety of human tissues, such as adipose tissue, nervous tissue, umbilical cord and amniotic fluid
that human umbilical cords contain large amounts of MSCs (Kern et al., 2006). Traditionally, umbilical cord tissue is regarded as a waste product after birth, so there is no ethical controversy to isolate MSCs from umbilical cord tissue compared with obtaining MSCs from bone marrow. The morphological, immunophenotype, proliferation, multi-directional differentiation and the ability to promote differentiation of hematopoietic stem cells (HSCs) in UC-MSCs are mostly similar to those BM-MSCs (Thaweesapphithak et al., 2019), but UC-MSCs have higher proliferative capacity and lower human leukocyte antigen (HLA)-ABC and HLA-DR expression than BM-MSCs. In addition, UC-MSCs with a wide variety of stem cells are well-sourced, easy to collect and preserve. UC-MSCs are expected to be an ideal alternative source for BM-MSCs. UC-MSCs play a unique role in reducing incidence and severity of graft versus host disease (GVHD) which occurs in more than 50% of patients undergoing hematopoietic stem cell transplantation
Негізгі бет What is stem cells? What are the different types of stem cells ?
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