The fact that you can't un-bake a cake is profoundly disappointing.
@JACE_75
Жыл бұрын
Thank you for another excellent video. 👏🏾
@savvasgamingchannel5062
Жыл бұрын
With what I have understood so far, it is a choice between damage to the basic DNA or to damage to the maintenance software known as epigenetics . Sinclair is trying to get the epigenome to repair because DNA seems to be wholly intact into old age, whereas the epigenome and body tissues show signs of wear and tear.
@over2seeyer
Жыл бұрын
it would be amazing if the DNA is truly intact
@jobyyboj
9 ай бұрын
@@over2seeyer There is cell recycling, so damaged DNA is diluted over time, depending on the cell type. (eg. Neurons have limited turn over). Aging interferes with both the effectiveness of immediate DNA repair and the cell recycling also, a truly vicious cycle.
@GeoffryGifari
Жыл бұрын
hmmm... this might sound naive, but what if we age because the primary function of living things is to reproduce (even more than the survival of one individual organism)? having ancestors that never age will just intensify competition over resources for the offspring
@GeoffryGifari
Жыл бұрын
related to this, is it possible to slow down the aging of reproductive functions? having the gametes being the same quality while the organism gets older
@KimLumbard
Жыл бұрын
Howdy Sheekey! Alan Green (the rapamycin doctor) believes that aging is the organismic analogy to cellular apoptosis. Meaning, it's a completely programmed evolutionary response, to do things like free up resources for younger organisms by killing off the old as well as accelerating generations to get more sexual intermix of genes = more rapid evolution. It's a pretty compelling notion, especially when you start positively correlating organismic mortality to the rate of species evolution. I think the most compelling evidence for the conceptual capability to reverse aging is babies (as you mentioned) and regenerative species. We already know our genes can "start afresh" with every generation, and we are already familiar with many species with fantastic abilities to regrow parts of itself. That suggests the ability is there somewhere in our biology... we just need to be able to turn off the aging program(s) and selectively activate the right stuff. I'm glad sharp people like you are on the job figuring out how to do that for the rest of us. Thanks.
@danmosenzon1477
Жыл бұрын
I very much dislike wishy-washy metaphors. Especially when they are so vague and lacking in predictive power. They can sometimes fill in holes in a theory that is otherwise very fleshed out. But many of these aging theories rely on them as core pillars.
@rezabidar1042
Жыл бұрын
No I don't think we are programmed to age, rather we are not programmed not to age. Btw, addressing aging in human is much more difficult than addressing individual cells aging. There is also a cooperation component in our body, in the sense that our 37 trillion cells are programmed to happily work together. One needs to address aging of individual cells in such a way that not turns the cooperation to competition, if that happens it leads to cancer, that is why in reality it’s going to be much more difficult than it seems.
@nerolowell2320
Жыл бұрын
read the ancient history start with the Sumerians tablets, we've been programmed to age
@david-jr5fn
Жыл бұрын
De Senectute" (On Old Age) by Cicero (44 BC): A philosophical treatise on the challenges and benefits of aging, written by the Roman statesman and philosopher. "The Art of Living Long" by Robert Burton (1620): A guide to healthy aging that includes advice on diet, exercise, and lifestyle, as well as discussions of medical theories and practices of the time. "The Anatomy of Melancholy" by Robert Burton (1621): A comprehensive study of melancholy and related mental health issues, which includes discussions of aging and its effects on the mind and body. "Le Parfait Vieillard" (The Perfect Old Man) by Antoine de Gouveia (1629): A treatise on aging and the virtues that are necessary for a fulfilling and happy old age. "The True Enjoyment of Age" by George Wakeman (1680): A collection of essays on the pleasures and benefits of aging, including discussions of retirement, wisdom, and the joys of grandchildren. "The Fountain of Youth Discovered" by Johann Friedrich von Funk (1701): A medical treatise that explores various theories and remedies for slowing or reversing the aging process, including the use of herbs, minerals, and other substances. De Vita Longa" (On Long Life) by Johannes de Sancto Paulo (circa 1400): A medical treatise that discusses various factors that can contribute to a long and healthy life, including diet, exercise, sleep, and emotional well-being. "Regimen Sanitatis Salernitanum" (The Salerno Regimen of Health) (13th century): A medieval medical text that includes advice on healthy living, including diet, exercise, and hygiene. It also includes sections on aging and the care of the elderly. "The Old Man's Guide to Health and Longer Life" by John Smith (1550): A guide to healthy aging that emphasizes the importance of moderation in diet, exercise, and other aspects of daily life. It also includes sections on the care of the elderly and the prevention of age-related illnesses. "De Peste, senectute et morte subita" (On Plague, Aging, and Sudden Death) by Girolamo Cardano (1576): A treatise that explores various theories of aging and the causes of sudden death, including discussions of the importance of exercise and the dangers of overindulgence.
@rredding
Жыл бұрын
Taken from a pess release from the University of Tilburg "31 August 2017 - On average, people live longer, but the very oldest among us have not gotten any older over the last thirty years. This is shown by forthcoming statistical research conducted by statisticians Jesson Einmahl MSc and Professor John Einmahl of Tilburg University, and Professor Emeritus Laurens de Haan of Erasmus University Rotterdam. They base their conclusion on precise ages at death of 75,000 Dutch people who died in the last 30 years at the age of at least 94. With the help of so-called Extreme Value Theory, the statisticians discovered that a clear ceiling exists for the maximum age to which people could live. For women it is estimated at 115.7 years and for men at 114.1 years. This maximum age has not increased in the period under review, from 1986 until 2015, even though the number of people reaching the age of 95 almost trebled. The maximum ages mentioned above are estimates; the true values can deviate upwards to just above 120 years. In 2016, an article written by American biologists appeared in the scientific journal Nature in which they argue that, although average life span has risen, the maximum life span has not increased, actually decreased, since 1995. However, according to many scientists, that research was based on flawed statistics. The present research has shown that there is a more or less constant ceiling to the maximum age in sight after all. Extreme Value Theory is a branch of statistics that answers questions about extreme events (which, by definition, do not often occur) based on information about less extreme events. The theory is often applied in the world of finance and insurance......." Now let's see what comes from recent developments. Well know around 2045?
@jesseshaver2262
Жыл бұрын
What anti aging or reversal of aging methods/tech do you think we will see in the nearish future (seems like you see the most promise in epigenetic reprogramming?)? If any. And when do you think we will see them available to consumers?
@stevebelzer4758
Жыл бұрын
You can reprogram your epi genome by subscribing to Apple Music and creating an anti Horvath playlist
@themacso4157
Жыл бұрын
@@stevebelzer4758 u can also do that by turning off ur cellphone
@jobyyboj
9 ай бұрын
See: Alto Labs for research, with $$$ billions of backing, including the sic 'infamous'??? Nobel winning Yamanaka himself. See Sinclair Lab for upcoming clinical trials for human eye treatments, results most recently published for Non-Human Primates.
@ebizguy23
Жыл бұрын
Your video is playing double audio - two audio tracks on top of another - please listen to it and fix it. The best analysts on Earth are very interested in watching it...Sincerely, Kim
@Firestorm12345678910
Жыл бұрын
I don't think there is such a thing as aging but rather reproductive aging. We are grown to our reproductive age and we describe that as young colloquially the best years of our lives. After that certain period of time the organism continues to be reproductive (ie ovaries in females don't get reabsorbed into the body, males don't stop producing sperm cells) however now it's about how well the body can maintain it's reproductive fitness otherwise known as old age. In essence to be biologically "immortal" is to be biologically forever optimally reproductive. Now of course with transhumanist technologies we can control, define, design the body according to human intentions and desires (despite not even knowing as of yet if we are agents of ourselves).
@bogrunberger
Жыл бұрын
Wonderful video. Thank you for that! Something I've been thinking a lot about is how society will be impacted if people can suddenly live for at few centuries instead of approximately 80 years as they do now. As you grow older you get more set in your way and more or less you get fixated. Your opinions aren't as easily changed, you don't try as many new things as you did when you were 20 because you know what you like and so you do that instead of trying new things. I think this will have a big impact on our society when a larger proportion of it is composed of older people. Our society will get less elastic and more conservative (in the litteral sense). I fear young people will struggle because they will belong to a smaller and smaller part of society and will become a minority.
@DrAndrewSteele
Жыл бұрын
Great question, and you might enjoy the free chapter of my book Ageless on the ethics of ageing biology which talks about just this! Search for ‘andrew steele ageless ethics’ if you’d be interested to have a read. :)
@ChessMasterNate
Жыл бұрын
Those conservative impulses may in some way be hormonal or in other ways characteristic of the biology. It may be, being physically young continues to make one behave young. You may in fact get the opposite effect, with there being no or few physically elderly for a long time.
@geoffreyhalverson1787
Жыл бұрын
Check out "Cracking the Aging Code" by Josh Mitteldorf. His argument is that individual death protects the larger species and environment from over population.
@RagdyAndy
Жыл бұрын
what was all the multi audio at the start?
@Sam-shushu
Жыл бұрын
great video. I'm just sad there's no answer 😂
@GeoffryGifari
Жыл бұрын
huh, a cell's epigenome can be reset? can a methylated DNA be un-methylated? fascinating!
@nopara73
Жыл бұрын
Even if it's a hardware flaw, hardware is just calcified software😊
@KenOtwell
Жыл бұрын
The DNA is the library of life, and the epigenome is the librarian who decides what to read and when to read it. Is the librarian also encoded in the DNA, or is it inherited separately like the Eve Mitochondria theory?
@david-jr5fn
Жыл бұрын
I wonder what the Victorian's thought was the cause of ageing. I know that the rich Victorians would keep a small snuff box with them that contained flours of gold, finely powdered pure gold and they would add a pinch to their food in the belief it would extend life
@ahmedalhajri6175
Жыл бұрын
enlightening video. thank you
@alexfox2038
Жыл бұрын
Wow, thank you for this great video. Especially the part where you talk about slowing down development has many interesting implications. As anecdotal observation one could taje young lifters who hop on steroids. The steroids allows them to develop muscle faster but they look way older than they really are and mostly don't have a longer lifespan.
@PeterPeanut
Ай бұрын
Aging to me is very interesting aswell, I think about it sometimes and I am interested in the siences, I love to theorise about it. If it is meant to be it is meant to be. But if it is something that can be avoided that would be wonderfull. Feel free to correct me in the things I have wrong! So let's have a little thought experiment! Embryo's at an early stage have totipotent cells, eventually they grow into different types. But what is the trigger of them dividing into different cell types, in what "state" does that happen and how is that communicated? Now with that in mind what would happen if you would keep taking the totipotent cells away? Would the cells keep dividing to reach a certain treshold of cells or would they eventually change? I believe this might be a fundamental insight into understanding why cells might degenerate as we get older. Cells communicate with each other and the "state" of the cell itself and the neighbouring cells are rather important, cause it might define what a cell does. Would cells keep dividing when it is not needed, that would be cancer cell behaviour it knows when to stop! The stem cells of our body turn into and replace the non stem cells right? But eventually they to do degenerate and die!? That makes no sense cause (Telomerase activity is present in most types of adult stem cells, though at substantially lower levels) they can regenerate telomeres! Altough very slowly, but my question is it slow because it is in a "state" with more urgent prioritys like replacing other cells etc. There must be some kind of priority, cause would embryonic stem cells at their earliest stage be like nah I am gonna change into some other cell type already instead of dividing for the propper amount of totipotent stem cells to continue the embryo's development. If cells behave according to different states, wich would also be heavily dependend on the environment of the cell! Would it be possible to enter a state of rejuvenation or in this case increased telomerase activity! Would this be possible if we reduce the amount of stress our body endures? During sleep our body replenishes energy and repairs itself, any activity requires energy and many cells have fallen during day times! If we put less pressure on our body and it not requiring as many repairs could we enter a state of restoration / rejuvenation, where cells focus on different things less important to keeping us working and alive. We don't live with society foccused on our body's, our body's live foccused on what society requires of us. Take an alarm clock for example either way I can't think of such things a s trully "healthy". Just like many other behaviours and habits we have from food to everything else. There is more I could say about this, but I am gonna keep it at this. Thanks for your video!
@andreigheorghe3135
Жыл бұрын
This was an AMAZING video!
@peterz53
Жыл бұрын
Thanks! Maybe time for an interview with Bjorn Schumacher? Or a detailed breakdown of his lab's paper on DREAM? Seems that p53 may have a role.
@monnoo8221
Жыл бұрын
Thanks for the discussion of those. Though, one can not take Lakatta's paper serious in any respect. Honestly, the oldest book came to the best conclusions. Both the onion type model, with its notion of mutual enslavement, and the hardware software distinction are just utterly naive. All three however, fail to recognize the topological structure of a living metabolism. They are all, as usually in biology, completely missing any proper abstraction, deeply poisoned by positivism. Where in a associative network, both bottom up and top down controlled while being under environmental influence, should the software, or the hardware, be? That kind of classification imports deeply inappropriate figures of thought, and the author of such does not understand anything of biology at all. It is proposal exhibiting deep despair and hopelessness. A protein is both hardware and software, because it is measured and is acting as effector at the same time. Lakatta's notion of software has long been overcome by Epigenetics. His positivistic view that is locating information just in the DNA is truly from the 1960ies. The notion of "design flaws" is arrogant to the brim. Did he ever hear about evolution??? Th evolutionary perspective was completely neglected. So, evolutionarily, why do we die? It s a game of probabilities. The F2 offspring is only related 0.25 to yourself, F3 only 0.125. F2-, that is grandmoms\-pas help in raising F2... sometimes, but would not do so significantly to the advantage of heir own genes in F3. One could write a whole book about the ramifactions of that, but Dawkins "Selfish gene" is good starting point. Living too long comes with the cost of being less adaptive, materially. Only if the species develops culture, the old age potentially pays off. Such, there is even a selection pressure to get non-functional at a certain age, not because the organism got sexual active early, but because the F3 generation follows soon. The position n the trophical hierarchy does count here. There is no programming and no "design flaw".. only for engineers and those complaining about not being god-like. If it would have been evolutionarily feasible, then there would be a solution. The complexity of the living metabolism is out of reach, by far for us. It is a great achievement to improve healthspan by targeting some key mechanisms, and even prolong for some time, by introducing repair mechanisms or strengthening the bodies wn. But the whole piece will fall apart over time. Remember, centenarians of 120+ often die because there immune system looses its capability for variability, then dying by lung infection. All other systems still working fine. Where do those losses start? It is simply a matter of probabilities. There is no "cause". So, you are young. try to work on this game of probabilities.
@Firestorm12345678910
Жыл бұрын
monnoo: "But the whole piece will fall apart over time." That is unless you go chrome, I mean becoming a cyborg. It's not impossible to replace a biological neuron (or neurons) with an artificial one (via ship of Theseus method). Albeit after such a transformation I would not know what the heck we would call ourselves. Transhumans? Posthumans?
@monnoo8221
Жыл бұрын
@@Firestorm12345678910 yep, basically you can do that. a few replacements on a low level of integration, yes, perhaps. Until you replace too many with a basically deficient artificial version, which does not provide long-term, or long-range, integration capabilities. then you may experience catastrophic failure from one to the other moment. The animal physiology, and particular ours, is so mindblowingly complex... note: complex, not: complicated. even if we one day collected absolutely all biochemistry, this would be just a mediocre beginning. Why is this so? the answer is.evolution. everything gets linked to everything else, everything has a structural and a control role, and any arbitrary sufficiently large collection of individual reactions creates emergent traits. Remember: the game of biological evolution has a clear purpose, even if that appears a-post. And that is to become independent of physics, =physical constraints, first, then from chemistry = biochemical constraints. Because at the end the survival of pieces of information in a social context is all that matters. Humankind has a long long way still to go to understand that, and its ramifications.
@FoZeusMaximus
Жыл бұрын
Thank you.
@Derby08
Жыл бұрын
Love your podcasts..
@avono5330
Жыл бұрын
0:18 I close the KZitem, so many times, even turned off my phone lol then I realised it was the video
@korniszon68
Жыл бұрын
I have a problem to understand your videos. I was trying multiple times, but the way you speak just keep me trying. No idea. Maybe it is just my hearing damage or poor English level. But I do not have such a problem with any other English video, and I'm watchig tons of it. It is sad, because I have a feeling your content is valuable.
@FibraXir
Жыл бұрын
I find it hard to believe that there would be such a simplistic input approach to increase the lifespan of an organism. These types of traits like lifespan, predation rate, and so on (and the relevant factors contributing to their variance) are very much self-regulated ones, as their increase will inherently eradicate the conditions that gave the possibility for them to emerge on the first place, be them ecological relationships, niches, etc. On that note, there would probably be hard evolutionary funnels inhibiting these hard variations from tipping over critical points, and resulting in the degradation of the overall network that gave the possibility of them to emerge. As such, one of the easiest ways to achieve that is to add more layers of regulation, such that environmental inputs, or any other type, are more easily allocated, reinforcing the robustness of the respective organism. As a trend, you would probably see targets that emerged earlier evolutionarily with bigger regulation than newer ones. Whilst you may have a possibly larger increase of lifespan by targeting older targets, you would probably have bigger repercussions following that, as there would be reallocation of inputs (you are no longer in the same initial conditions as those prevalent in developmental stages, i.e. after some time subsequent to the therapy application to the respective targets, you would perhaps see an increased senescent phenotype). With evolutionarily newer targets, whilst you might not have the same therapy output magnitude, you would atleast probably have less repercussions. In essence, you would trade efficiency with safety. I don't think there are "free lunches" in short evolutionary scales. You would probably have an easier time increasing someone's lifespan by convincing them that they going to live longer, and have placebo effect and top-down constraints take over, and just take the resulting answer "for free". Bottom-up and reductionistic approaches rely heavily on you solving an essentially infinite combinatorics game, and with that not even taking into account that you inherently lose emergent processes by decomposing these systems into their components.
@FlyoviaUSA
Жыл бұрын
The grey hairs on my beard and scalp are definitely not coming in symmetric. 🤣
@Aryeh-o
Жыл бұрын
we age so that we can research the cure
@ragnatouya5050
Жыл бұрын
I've been contemplating about these Is subject and have some up and down to what you have read and what are mind is capable to do! But i can be wrong.😢
@nootri
Жыл бұрын
Yamanaka factors are infamous ?!
@antoniosmusic
Жыл бұрын
Light Reading!!!! 😂😂😂😂
@mozg3d
Жыл бұрын
I just lost 16 minutes of my life for nothing(
@Truerealism747
Жыл бұрын
Because governments gave us a national insurance number and a date if birth and a perception when we should die.
@unesversa-dh3yh
Жыл бұрын
the truth is I never olds it we'll be back in a baby mode🤣
@unesversa-dh3yh
Жыл бұрын
soul baby God🙏
@davidroush1224
Жыл бұрын
I think it may be possible to reverse the "baked cake." The ability of some living organisms to regrow severed limbs leads me to consider this pathway might be utilized in the future in regenerating organs/etc. in place(vivo) at some future point. Exciting couple of decades ahead.
@tadasturonis
10 ай бұрын
6:45 i think the solution to aging is GPU acceleration
@unesversa-dh3yh
Жыл бұрын
that's the way it is miracle🤣
@unesversa-dh3yh
Жыл бұрын
the miracle begans to life how it exist from nothin no one can answer right🤣
@mpen7873
Жыл бұрын
Good video 👍
@whatthefunction9140
Жыл бұрын
Puberty is seen as a positive programmed stage of aging
@dionysusnow
Жыл бұрын
I see you haven't had kids yet.
@stevebelzer4758
Жыл бұрын
So .. in 1939 , all DNA began to FAIL telomeres began to shorten Reality began to shift , from biological software to hardware GPT4 chatbot surmises that epigenetic damage causes mice to age affecting human DNA free Radicals . Will this be on the final exam ?😂
@HatiKeseorangan
Жыл бұрын
ez how to leave 1000 year.... just get healthy nature green oxygen... and living without oxygen... there have a reason why blood carry oxygen cycle to our body... quality of the oxygen also is important...
@alwayslearning8365
Жыл бұрын
Than you for the information.
@lightghost7524
Жыл бұрын
There's a huge social component to ageing and life expectancy. It's easy to observe it by looking at the life expectancy gender gap i.e. 6 years in the US, 12 in Russia, 8 years in my eastern European country
@unesversa-dh3yh
Жыл бұрын
Jesus Christ amen🙏
@unesversa-dh3yh
Жыл бұрын
magic powers is impossible from death🤣
@unesversa-dh3yh
Жыл бұрын
it's by the book covenants bible its is the way🤣
@unesversa-dh3yh
Жыл бұрын
not some one book fooling you.🤣
@immortalityIMT
Жыл бұрын
Ye, then why don't neurons do that? By cause of non division? 🤔
@unesversa-dh3yh
Жыл бұрын
be truth no one knows it 🤣
@medicinefuture
Жыл бұрын
if your talk is designed to be for the public,it needs to be more in slow motion, why the hurry, and also needs to be simplified more than that, except for that you have a brilliant mind
@unesversa-dh3yh
Жыл бұрын
the story of God is better than other story 🤣
@N330AA
Жыл бұрын
Summary: Turn the system off and on again
@nerolowell2320
Жыл бұрын
how do you do that? long term fasting ?
@johnthefisherman2445
Жыл бұрын
I think thats the plan but can we do it to the trillions of different cells in your body.
@johnthefisherman2445
Жыл бұрын
@@nerolowell2320 they are referring to epigenetic reprogramming.
@Blurns
Жыл бұрын
@@nerolowell2320 Nobody knows, and I guarantee you fasting isn't the answer.
@darkhorseman8263
Жыл бұрын
If you mean government regulating to disrupt the slave and master oscillators of circadian rhythm and epigenetic quality control through food and environment, then sure. Most of the dysregulations with age are linked to stress hormones, nutrients, or lack of epigenetic oscillators, leading to epigenetic drift. A lot of it is avoidable.
@KenOtwell
Жыл бұрын
We had aging and death from old age way before we had a government or man-made environmental damage. Not saying these aren't bad things - but they're not the droids you're looking for.
@MrCoffis
Жыл бұрын
Are we programmed to age? I think no. We are just not programmed not to age. There was no evolutionary pressure for longevity hence why we age. But also entropy…and death is what reduces entropy.
@batsmasherbatsmasher3177
Жыл бұрын
Its not a flaw , its by design but the ultimate goal for this design is to let humain find away to reverse aging . the Creator implemented these obstacles so you can as humain evolve and find soultion in life .
@garystillman2724
Жыл бұрын
enslavement sounds communist to me. next youll be calling cell differentiation COLONIZING...... 🤪🤪🤪🤣🤣🤣😂😂😂
@SpringChickensOnlyMan
Жыл бұрын
Hope one we can lift mother natures sad curse upon us to save the sex life and possibly for me to live to the 2100s
Пікірлер: 84