Dear Armando, I am a chief physician and manager of an emergency clinic in Norway. In 2 weeks I am spending a whole day teaching our staff in causes of abdominal pain and symptoms from diseases causing abdominal pain. I needed a quick memory refreshener on the complete bilirubin metabolism to explain the aspects of jaundice and saw this.. This video is just simply brilliant! Thank you so much.
@shilpamankar1717
Ай бұрын
I am doctor passed out 15yr back.loved ur drawing.needed clarity and revision.so grateful for this.love from India.
@oreman011
4 жыл бұрын
as a MS1 I truly appreciate learning this stuff and then coming and watching your videos which allows me finally see how it all comes together and keeps the bigger picture in mind.
@RJay207
7 жыл бұрын
This was incredibly helpful, and presented in a much easier way to follow than in class. Thank you very much!
@hugodesrosiers-plaisance3156
4 жыл бұрын
I always watch your videos to review material before tests or quizzes, when I'm too tired to read or just don't feel like reading, or just want another take on material that's already familiar to me. You sometimes put things just a bit differently than my teachers do and that can make the material stick to my head much more easily. Your channel is an incredibly valuable complement to my teachers and their class notes.
@alexmilevskyy94
9 жыл бұрын
You do an amazing job sir! The graphics and explanations are terrific! Perfect marriage between science and art :)
@Tanayanar
8 жыл бұрын
You. Are. Awesome. I used to mug this up every year, all theough four years of medschool. Finally UNDERSTANDING it in my final year. Thank you so much. You have a gift!
@jaybee1196
7 жыл бұрын
Thank you Armando! After years of reading text books I finally understand jaundice with your animation.
@lenethlopez6383
2 жыл бұрын
You make things so simple. It took me 3 hrs to understand things by myself. What a life saver
@omarhameed
4 жыл бұрын
one of the best on KZitem to explain this cycle! good job!
@rosasgonzales9524
9 жыл бұрын
thanks a lot! really helped a lot in reviewing for my pathophysiology test. keep up the great work!
@nitinkulkarni6569
10 жыл бұрын
Excellent tutorial! Simple language makes it easy to understand the process. Thank you. - Nitin
@JJAngleton
10 жыл бұрын
Very nice video. Just for the sake of some more details, please allow me to further specialise and sum up: RBC when denaturing are taken up by Macrophages located predominantly in the Cords of Billroth in spleen, bone marrow and liver. It is an important point to understand that RBC normally do not undergo intravascular lysis. Billirubin is a breakdown product from Hb. Heme Oxygenase cleaves Heme (the Porphyrin part) into Verdoglobin (if Heme is still attached) or Billiverdin which will finally be reduced by Billiverdin-Reductase into Billirubin. Oppositely, Fe is recycled by Apoferritin in Ferritin and complexes to Hemosiderin. Note: This function of Hb breakdown by HO can occur in virtually every cell and is NOT liver-specific. In liver, hepatocytes release Billirubin-binding-proteins in the circularly system. Those newly formed complexes of Plasma-Protein-Bound-Billirubin are too large large and cannot diffuse back to microcirculatory system. Note: Up to now, we are still talking about unconjungated (indirect) Billirubin which is not water soluble due to intra molecular hydrogen bonds and thus cannot be filtered into urine. This form, still in the circulatory system, is highly toxic, but now trapped. Trough the hepatic artery and the portal system it goes to liver which will take it up. Within hepatic sinusoids, it enters the endoplasmic reticulum and will be conjugated with Glucuronic Acid by GT (Glucuronyltransferase). It became now highly polar and trapped within the hepatocytes. On the canalicular side of the hepatocytes are active transporters that will drain it into biliary ducts. Next it will be concentrated in bile and finally released into GIT. Microbes and enzymes will convert it now into Urobilinogen. Some is reabsorbed and goes back into enterohepatic cycle and since it is highly polar and unbound, it will be renally filtered and passed out by the urinary tract. However, the largest part will remain in the bowl and be converted by bacteria into Stercobilinogen which will be oxidized into Stercobilin that makes the dark color of feces.
@iloveu975
9 жыл бұрын
Very well explained! The enzymes are crucial to know for exams
@ateequrrahman3133
6 жыл бұрын
nice addition to the video, I was looking for these enzymes.thanx a lot
@DrDhyan-wr6fi
6 жыл бұрын
Thanks man
@ashalavylo
5 жыл бұрын
MarC NIcolA Fraessdorf thanks a lot for your explanation. But it's said that urobillirubin is bound to albumin after absorption (6:56) and you say that urobillinogen is highly polar and unbound. So what's the truth?
@josefsterner6000
4 жыл бұрын
Much obliged buddy!
@lydiaquintanaa
Жыл бұрын
I love your videos, the drawings look amazing, and you can really see the effort in them. The explanations are amazing. Super grateful for all your work.
@NYOKO993
3 жыл бұрын
Super helpful!! Thank you so much for clearing this up with your amazing illustrations!
@oguzhanpolat21
5 жыл бұрын
I was just spending hours to understand bilirubin metabolism, until I saw this video. You do great job.
@aishastar1000
9 жыл бұрын
amazing videos! keep them coming please :D any on the brain, muscles and neurology? (im a medic and these have helped greatly!)
@smech75
6 жыл бұрын
What an explanation. Even a illiterate can understand easily. The uses of different colour and explanations of everything made it so easy to understand. I really appreciate your work from heart and mind. Thank you for sharing such an awesome video.
@usmanahmed3173
8 жыл бұрын
Sir you got amazing skills , mind and a great method of teaching ! I am a Med student I found your tutorials very useful specially when Im studying guyton for physio...
@mariamohsin3486
3 жыл бұрын
Have u finished mbbs as yr comment was posted 5 yrs ago??? And now I'm here..i'm 1st yr mbbs student
@user-hy6xw4zi5k
4 ай бұрын
I have come back to this video quite often so far in my medical career. Thank you for this concise explanation!
@Ventus2077
8 жыл бұрын
So artistic, very well explained and enjoyable to hear too. Thank you so much it was very helpful
@joaovitorpimentel2140
7 жыл бұрын
Agreed.
@GravisTKD
10 жыл бұрын
As someone who has been diagnosed with Gilbert Syndrome (elevated blood concentrations of unconjugated bilirubin), this is a great video to see. I love what you're doing!
@Ramon29
Жыл бұрын
Hello How high was your unconjugated levels ? And what you do now to treat the gilbert syndrome ? Thanks
@mayaa1322
8 жыл бұрын
Dude! Thaaaank u sooooo much for the clarifying vid !!!!!💗💗💗
@BachanSinghBarthwal
7 жыл бұрын
Thanks for posting a great video on bilirubin metabolism
@josephwong7261
7 жыл бұрын
This was an excellent and succinct explanation, really helpful!
@sonam8868
4 жыл бұрын
That good feeling when you get great video of something you want to learn in first attempt . Thankyou for this amazing video and explanation
@sagarshrestha1945
Ай бұрын
I am veterinary Student and it is very helpful , clear doubts and gives the image in mind which is remembering in lifetime❤
@aireennero7534
3 жыл бұрын
WATCHING FOR THE 'NTH TIME!!!! YOU'RE AWESOME ARMANDO!!!!! THANK YOU VERY MUCH!! YEARS OF SITTING IN MY CLASS WAS NOTHING FOR EVERY FEW MINUTES SPENT WATCHING YOUR WORK!!!! GREAT JOB!!!!
@westfield90
10 ай бұрын
Stunning how all of this is continually happening and each part of the body is doing its part. Amazing mechanism.
@ranoshaalazzawi3240
7 жыл бұрын
im so enjoyed with your amazing explanation now I have the final exams and I cannot leave your videos . big thanks for you
@christinafrank2674
8 жыл бұрын
Thank you for your videos! They are always so amazing!
@mafaldajardim
7 жыл бұрын
Uau! This is amazing stuff. What an artist. Thank you so much for such a helpful and visual lecture.
@norhanelkashef7202
4 жыл бұрын
Thanks Dr. Armando for your efforts ,you have such a great passion in teaching medicine as if you are playing piano.
@kristen4698
5 жыл бұрын
Good video! Really helped my understanding of bilirubin metabolism!
@TheBobelly628
10 жыл бұрын
Great video and explanation as always! If you ever publish a book of your drawings Iet me know since would purchase it :-)
@trdzika1983
5 жыл бұрын
you are such a good teacher.well presented.greetings from Zimbabwe
@flashscott08
10 жыл бұрын
great video man I like all the videos you do. Just to add an extra step when the haeme is converted to bilirubin there is an intermediate step whereby the haeme is cleaved by haeme oxygenase a cytochrome P450 enzyme to biliverdin. This biliverdin is water soluble unlike bilirubin and it is the enzyme reduction of the biliverdin via biliverdin reductase that creates the lipid soluble bilirubin.
@gassaniamalia9889
9 жыл бұрын
COOL!! Please keep sharing us the useful knowledge like this, so clear and comprehensive!!
@ayeshafayyazaf
7 жыл бұрын
your videos are so sharp and understandable. you are a very enthusiast tutor. keep on the good work.
@vaidhyanathanbalasundaram1224
3 жыл бұрын
Excellent. Very useful video. Explained in simple words , in a clear voice.
@mariamohsin3486
3 жыл бұрын
It's the 1st video i am watching on this site.. it's really helpful.thanks sir and keep it up.
@alishahightower1706
3 жыл бұрын
You are AMAZING! I'm a visual learner and always follow up my reads by listening to your videos; which immensely aid in the retention of this knowledge. I have vowed to donate in the future! Thank you for all that you do!
@pabloblanco2656
2 жыл бұрын
Wished someone would make a video on the causes of chronic elevated bilirubin
@DottiOnTheBigScreen
6 жыл бұрын
This is a fantastic video!! really informative and helpful! thanks!!
@kehuang4477
9 жыл бұрын
This presentation is amazing. Thank you!
@user-pb7py3jp8f
7 жыл бұрын
excellent explanation, you made it nice and easy ! thank you.
@hiteshkaria354
8 жыл бұрын
superb explanation....Fantastic teacher.....awesomely explained...So very very well simplified.....keep up the good work. God bless....cheers....
@dream7348
5 жыл бұрын
really easy to understand and your detailed explanation. What a great video!!!!!
@mus643ful
8 жыл бұрын
He his the best teacher i have seen
@LesaneBH
10 жыл бұрын
Great explanation of metabolism. Of course you missed some parts but that is understandable. I'm curious where did you find that information, that urobilinogen is absorbed by colon ? :O
@alejanaramb
4 жыл бұрын
he said 10 - 15% was reabsorbed into the blood and the rest excreted after being oxidized giving poo its color the large intestine does not absorb any.
@pauillac1996
7 жыл бұрын
i agree with christopher! i too would buy those diagrams if they were available. really helpful, so clear, fantastic!!
@nadahanna8325
8 жыл бұрын
you are one of the best lecturer ever ...well done
@tomkrstevski5619
7 жыл бұрын
Great Explanation of the process of Bilrubin, examples are excellent and well explained
@ull893
9 жыл бұрын
You are a life saver ! I would not have never understood this without your video. Thank you.
@ellenhossam8315
5 жыл бұрын
Super simple and creative , thank you very much .. keep going ❤
@julijat.3015
9 жыл бұрын
Thank you very much! All of your videos are brilliant
@tobelovedbefore
8 жыл бұрын
thank you armando, you're amazing!
@fairouzh2472
3 жыл бұрын
You are fabulous !!! Just WOW !!! Keep it up cuz You're the BEST 💪🏻
@narjesali9559
8 жыл бұрын
you made it so easy, I'm very thankful
@olamideajewole3352
5 жыл бұрын
Brilliant illustration. Thank you! :D
@MNVanny
2 жыл бұрын
Amazing explanations you are one of my best you tube tutors
@indiramassie6237
4 жыл бұрын
Maravillosa la explicación! Sin palabras . Muchas gracias. Dios te bendiga 🙌🏾🙏🏾🇨🇺🇨🇺
@ph3124wr
8 жыл бұрын
How an amazing teaching video I have ever seen!
@donnah313
7 жыл бұрын
thaaaaank you so much, that was really helpful!
@aswinkayastha8575
5 жыл бұрын
Very helpful.. thank you so much for this videoo.. you have clarified this in so easy way...
@gikerdak868
4 жыл бұрын
thanks a lot Armando Hasudungan for your help
@travisswadling2724
8 жыл бұрын
Love your videos mate. The only thing that you could change that I believe would make it twice as good would be the addition of english subtitles. Any chance of that ever happening? Other than that, I absolutely love your videos!
@linngu2594
4 ай бұрын
Thank you very very much. Although I am a non- medical trained person but this has helped me to understand why a young member of family’s bilirubin has doubled since entered university. He does has constipation prob. & likes eating ready made meal. I think for his case the fix is stop junk foods, drink plenty, more fibre & Magnesium citrate to discharge stool and possibly taking ox bile or similar. Thanks again❤
@laladylann
7 жыл бұрын
YOURE AWESOME ARMANDO!! ITS SUCH ENLIGHTMENT! THANKS SO MUCH FOR MAKING THESE! KEEP UP UR AWESOME WORKS! WE DOCTORS TOBE OWE YOU MUCH!!!
@renakim7163
9 жыл бұрын
amazing!! great lecture video.. thanks!!
@drvinson8947
3 жыл бұрын
Best explanation I’ve seen on this. Thanks.
@chumnithhs431
9 жыл бұрын
Thank you for your explaination....good job
@arifbudisantoso1415
6 жыл бұрын
I hope you make another videos about medical, its so helpful for us to understanding the case, or the theory, thank u so much brother.. God bless you..
@razanrabih6963
7 жыл бұрын
oh my god it was really helpful and I enjoyed every second of this vedio... thank you soo much sir ♥
@turkimuaddi5286
6 жыл бұрын
Thank you so much for simplifying the pathway
@Basel93x
9 жыл бұрын
Straightforward and complete, thank you
@alisinan9934
4 жыл бұрын
Understood much better than a whole year of med school!
@tiffanyrichardson8340
6 жыл бұрын
Your videos are the greatest! Nice work.
@kenzakhiat2981
6 жыл бұрын
Wow !! Thank you so much for your hard efforts, it really helps me a lot.. I checked your website, and it's amazing.. Again, thank you, and keep up the good work !!
@priyasuresh8979
5 жыл бұрын
thank u so much sir ,very nicely explained with good draw,ur great
@shijink74
2 жыл бұрын
Fantastic piece of work....... Nice explanation in this short time ....
@wanazreen9161
5 жыл бұрын
thanks great explanation... clear , accurate and precise... help a lot
@zohaibkhanzaur9286
3 жыл бұрын
Brilliant work sir
@camibri.p
10 ай бұрын
Muchas gracias!
@helical_hippo
9 жыл бұрын
You should release the final thing as a poster. I'd even pay a little bit for it!
@nurinhazman9663
9 жыл бұрын
David Grainger I second that. pls do sir.
@olgapawlik474
8 жыл бұрын
+Wan Nurin Yes please! I try to recreate them but I'm so bad at drawing. My liver is an inverted triangle..
@saimaarshad9756
5 жыл бұрын
you can become a patron on patreon to get HD pdfs of the whole thing
@earlbalesclinicdrallyk9486
5 жыл бұрын
yes I would like a copy of the posters
@user-wl9xk3io8n
7 жыл бұрын
ما شاء الله .. شرح اكثر من رائعععع
@JuanPablo-it1ll
7 жыл бұрын
It helped me a lot dude, greetings from Mexico.
@Monique47755
7 жыл бұрын
So helpful! Thank you
@rosemariegoolsby1048
7 жыл бұрын
Very informative video. I wish you taught my patho-physio class. LOL. Thanks for sharing.
@thunyalukniyomsilp6929
10 жыл бұрын
thank you so much I'm vet student. It's really helpful with your amazing drawing.
@ellenk8353
3 жыл бұрын
Perfect video!!! Thank you so much!!!
@belanishnianidze6488
9 жыл бұрын
thanks for this great video. graphic is also very good. please, would be great if you'd mentioned the enzymes as well
@kawinewmai
6 жыл бұрын
Nicely done . I enjoyed it . Superb drawings 😁👍
@darkmoon3646
2 жыл бұрын
U R A FREAKING LEGEND
@gurmitsingh4308
Жыл бұрын
Hey Armando, really blown away with the quality of information on the topic. What software you use for such awesome videos?
@yusufalhabr3261
9 жыл бұрын
excellent drawing..thx it helped me alot
@jenna-tn4wj
5 жыл бұрын
Very beautiful😍, thank you doctor شكراا🙏🏻
@Gankiao
Жыл бұрын
This made me want to study medicine again! Great explanation!
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