In the inaugural Coffee Break, I sit down with Ravi Menon to discuss two recent papers refuting the existence of a fast neuronal response named DIANA that was proposed in 2022. Ravi was a co-author on one of the two refutations. (The other comes from the lab of Alan Jasanoff at MIT.) We then digress into a brief discussion about the glymphatic system and sleep, and finally some other bits and pieces of shared interest. I've known Ravi for three decades and it's been a couple of years since we had a good natter, so we actually chatted on for another hour after I stopped recording. Sorry you don't get to eavesdrop on that conversation. It was all science, zero gossip and the subject of expensive Japanese whisky versus Scotch and bourbon did not feature, honest guv.
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Ravi Menon bio:
cfmm.uwo.ca/people/core_scien...
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References:
The 2022 DIANA paper:
Toi PT, Jang HJ, Min K, Kim SP, Lee SK, Lee J, Kwag J, Park JY. In vivo direct imaging of neuronal activity at high temporospatial resolution. Science. 2022 Oct 14;378(6616):160-168. doi: 10.1126/science.abh4340. Epub 2022 Oct 13. PMID: 36227975.
pubmed.ncbi.nlm.nih.gov/36227...
The two recent studies that failed to find a neural DIANA signal:
Choi SH, Im GH, Choi S, Yu X, Bandettini PA, Menon RS, Kim SG. No replication of direct neuronal activity-related (DIANA) fMRI in anesthetized mice. Sci Adv. 2024 Mar 29;10(13):eadl0999. doi: 10.1126/sciadv.adl0999. Epub 2024 Mar 27. PMID: 38536912; PMCID: PMC10971415.
pubmed.ncbi.nlm.nih.gov/38536...
Phi Van VD, Sen S, Jasanoff A. A different interpretation of the DIANA fMRI signal. Sci Adv. 2024 Mar 29;10(13):eadl2034. doi: 10.1126/sciadv.adl2034. Epub 2024 Mar 27. PMID: 38536916; PMCID: PMC10971484.
pubmed.ncbi.nlm.nih.gov/38536...
Latest preprint from the group that showed DIANA:
Detection of changes in membrane potential by magnetic resonance imaging. www.biorxiv.org/content/10.11...
An example paper showing cortical spreading depression from K+ on the exposed cortex:
Gardner-Medwin AR, van Bruggen N, Williams SR, Ahier RG. Magnetic resonance imaging of propagating waves of spreading depression in the anaesthetised rat. J Cereb Blood Flow Metab. 1994 Jan;14(1):7-11. doi: 10.1038/jcbfm.1994.2. PMID: 8263059.
pubmed.ncbi.nlm.nih.gov/8263059/
Neat wikipedia video of cortical spreading depression:
en.wikipedia.org/wiki/Cortica...
A 2023 review of work on MRI to detect neural activity directly:
(The original DIANA article is mentioned, but obviously not the two recent refutation papers.)
Roth BJ. Can MRI Be Used as a Sensor to Record Neural Activity? Sensors (Basel). 2023 Jan 25;23(3):1337. doi: 10.3390/s23031337. PMID: 36772381; PMCID: PMC9918955.
pubmed.ncbi.nlm.nih.gov/36772...
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What is Coffee Break?
We all know the best science at a conference happens either during the coffee breaks or in the pub afterwards. This being the case, practiCal fMRI and a guest sit down for coffee (or something stronger) to discuss some aspect of functional neuroimaging in what we hope is an illuminating, honest fashion. It's not a formal presentation. It's not even vaguely polished. It’s simply a frank, open discussion like you might overhear during a conference coffee break.
Disclaimer 1: You are eavesdropping on a conversation between two scientists. There may be colorful language, slang, acronyms and technical jargon. Sorry. There may also be rather poor audio-visual quality. Too bad, suck it up. You're eavesdropping, remember?
Disclaimer 2: No guarantees I'll read or respond to comments. Hopefully you will be able to figure out the acronyms and technical jargon using Google, or else post a question here and hope someone comes to your rescue. Comments about A-V quality? See the first disclaimer.
Негізгі бет Ғылым және технология Coffee Break! Ravi Menon, on why the fast MRI signals claimed in 2022 are unlikely to be neural.
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