Professor of Bioengineering at UC Berkeley
Faculty bio: vcresearch.berkeley.edu/facul...
Lab website: bisl.studentorg.berkeley.edu/
MPI company Steve co-founded: magneticinsight.com/
00:00:00 Introduction
00:01:38 What is MPI and how does it work?
00:10:56 Spatial-temporal resolution of MPI versus MRI
00:15:45 Commercial development of MPI scanners for animals and humans
00:17:03 Applications of MPI
00:24:52 Uses of MPI in stroke
00:35:55 Motion sensitivity
00:37:12 Risks vs benefits of a method requiring an injectable tracer. Does functional MPI make sense?
00:42:48 Intravascular magnetic particles: bleeding and blood-brain barrier leakage with MPI
00:49:22 Why no imaging of glymphatic system with MPI yet?
00:52:50 MPI vs MRI and PET
00:55:18 MPI and labeling of cells and antibodies
00:58:58 Longevity and stability: the key attributes of magnetic particles
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How Magnetic Particle Imaging Works - a book chapter with all the key concepts
link.springer.com/chapter/10....
A Review of Magnetic Particle Imaging and Perspectives on Neuroimaging
www.ncbi.nlm.nih.gov/pmc/arti...
Wu LC, Zhang Y, Steinberg G, Qu H, Huang S, Cheng M, Bliss T, Du F, Rao J, Song G, Pisani L, Doyle T, Conolly S, Krishnan K, Grant G, Wintermark M. AJNR Am J Neuroradiol. 2019 Feb;40(2):206-212. doi: 10.3174/ajnr.A5896. PMID: 30655254.
Functional magnetic particle imaging (fMPI) of cerebrovascular changes in the rat brain during hypercapnia
pubmed.ncbi.nlm.nih.gov/37531...
Mason EE, Mattingly E, Herb K, Cauley SF, Śliwiak M, Drago JM, Graeser M, Mandeville ET, Mandeville JB, Wald LL. Phys Med Biol. 2023 Aug 28;68(17):175032. doi: 10.1088/1361-6560/acecd1. PMID: 37531961.
Magnetic Particle Imaging (MPI): potential for functional brain imaging
Presentation by Clarissa Zimmerman Cooley, includes an intro to how MPI works.
• Magnetic Particle Imag...
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Other references:
Superferromagnetic Nanoparticles Enable Order-of-Magnitude Resolution & Sensitivity Gain in Magnetic Particle Imaging
pubmed.ncbi.nlm.nih.gov/34927...
Tay ZW, Savliwala S, Hensley DW, Fung KLB, Colson C, Fellows BD, Zhou X, Huynh Q, Lu Y, Zheng B, Chandrasekharan P, Rivera-Jimenez SM, Rinaldi-Ramos CM, Conolly SM. 2021 Nov;5(11):e2100796. doi: 10.1002/smtd.202100796.
Magnetic Particle Imaging: An Emerging Modality with Prospects in Diagnosis, Targeting and Therapy of Cancer
pubmed.ncbi.nlm.nih.gov/34771...
Tay ZW, Chandrasekharan P, Fellows BD, Arrizabalaga IR, Yu E, Olivo M, Conolly SM. Cancers (Basel). 2021 Oct 21;13(21):5285. doi: 10.3390/cancers13215285.
Non-radioactive and sensitive tracking of neutrophils towards inflammation using antibody functionalized magnetic particle imaging tracers
pubmed.ncbi.nlm.nih.gov/33614...
Chandrasekharan P, Fung KLB, Zhou XY, Cui W, Colson C, Mai D, Jeffris K, Huynh Q, Saayujya C, Kabuli L, Fellows B, Lu Y, Yu E, Tay ZW, Zheng B, Fong L, Conolly SM. Nanotheranostics. 2021 Feb 12;5(2):240-255. doi: 10.7150/ntno.50721.
In vivo tracking and quantification of inhaled aerosol using magnetic particle imaging towards inhaled therapeutic monitoring
pubmed.ncbi.nlm.nih.gov/30026...
Tay ZW, Chandrasekharan P, Zhou XY, Yu E, Zheng B, Conolly S. Theranostics. 2018 Jun 8;8(13):3676-3687. doi: 10.7150/thno.26608.
Magnetic Particle Imaging for Highly Sensitive, Quantitative, and Safe in Vivo Gut Bleed Detection in a Murine Model
pubmed.ncbi.nlm.nih.gov/29165...
Yu EY, Chandrasekharan P, Berzon R, Tay ZW, Zhou XY, Khandhar AP, Ferguson RM, Kemp SJ, Zheng B, Goodwill PW, Wendland MF, Krishnan KM, Behr S, Carter J, Conolly SM. ACS Nano. 2017 Dec 26;11(12):12067-12076. doi: 10.1021/acsnano.7b04844.
Design analysis of an MPI human functional brain scanner
pubmed.ncbi.nlm.nih.gov/28752...
Mason EE, Cooley CZ, Cauley SF, Griswold MA, Conolly SM, Wald LL. Int J Magn Part Imaging. 2017;3(1):1703008. doi: 10.18416/ijmpi.2017.1703008.
Magnetic Particle Imaging: A Novel in Vivo Imaging Platform for Cancer Detection
pubmed.ncbi.nlm.nih.gov/28206...
Yu EY, Bishop M, Zheng B, Ferguson RM, Khandhar AP, Kemp SJ, Krishnan KM, Goodwill PW, Conolly SM. Nano Lett. 2017 Mar 8;17(3):1648-1654. doi: 10.1021/acs.nanolett.6b04865.
Tracking short-term biodistribution and long-term clearance of SPIO tracers in magnetic particle imaging
pubmed.ncbi.nlm.nih.gov/28177...
Keselman P, Yu EY, Zhou XY, Goodwill PW, Chandrasekharan P, Ferguson RM, Khandhar AP, Kemp SJ, Krishnan KM, Zheng B, Conolly SM. Phys Med Biol. 2017 May 7;62(9):3440-3453. doi: 10.1088/1361-6560/aa5f48.
Evaluation of PEG-coated iron oxide nanoparticles as blood pool tracers for preclinical magnetic particle imaging
pubmed.ncbi.nlm.nih.gov/28059...
Khandhar AP, Keselman P, Kemp SJ, Ferguson RM, Goodwill PW, Conolly SM, Krishnan KM. Nanoscale. 2017;9(3):1299-1306. doi: 10.1039/c6nr08468k.
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