-- I am happy to answer any questions regarding organic chemistry in the comments --
This video will give you the theoretic background to understand the mechanism and the importance of different cross-coupling reactions.
Even if you have learned something about cross-coupling reactions before, this video will give you an overview about the different kinds of possible reactions, to help you deepen your knowledge.
In this video I will give you a full introduction to cross-coupling reactions: We will talk about the different components, the palladium-catalyst and it's properties, the four reaction of the catalytic cycle (Oxidative addition, Transmetalation, trans-cis-isomerization, reductive elimination), how catalyst precursors work and why they are being used, the four most common simple cross-coupling reactions (Kumada-coupling, Negishi-coupling, Stille-coupling & Suzuki-coupling), the reason why you can't use an alkyl-rest on the electrophile and some other useful reactions (Sonogashira-coupling, Buchwald-Hartwig-amination & Heck-coupling).
Topics:
0:00 The different compounds needed (nucleophile, electrophile, catalyst)
2:00 What you need to know about palladium
3:10 The four/five reactions of the catalytic cycle explained
5:50 What are catalyst precursors and why are they useful? (+mechanism)
7:16 Common reactions and there advantages (Kumada, Negishi, Stille, Suzuki)
10:13 The limitation of cross-coupling reactions
11:14 Useful reactions (Sonogashira, Buchwald-Hartwig, Heck)
Негізгі бет Ғылым және технология CROSS-COUPLING reactions - everything YOU need to know! (Full Introduction + overview)
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