While some form of fixation is essential for preservation of tissue structure, it is important to remember that all tissue fixation methods introduce subtle changes in tissue structure. These changes in tissue structure are collectively referred to as "fixation artefacts". In this teaching video from 2019 I demonstrate some of the more common types of fixation artefacts that can be observed by comparing samples of liver that have been fixed using either neutral buffered formalin, Carnoy's solution (an alcohol based fixative), microwaves, or Bouin's solution (a fixative solution supplemented with picric acid).
Негізгі бет Fixation Artefacts
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