There should be 4 hydrogen pumped from III, and two hydrogen from IV
@sofiem1225
Жыл бұрын
That' true if you look at a whole Q-cycle and ½ O2. I think he chose ½ of a Q-cycle (so one QH2) and one O2 :)
@ashnapillai5661
3 жыл бұрын
I love how you reinforce your points constantly, it makes the whole concept a lot easier to understand! Thank you :)
@anjalimicrobiologist9938
Жыл бұрын
10:13 Nice video sir, but I would like to correct you at the number of hydrogen pumping from complex III and IV which are 4&2 respectively. Hope you will consider this.😊
@itzelvidal7672
7 жыл бұрын
I'm so glad I found your channel. Your videos are the best. Thank you so much ❤️
@gabriellepadley3015
3 жыл бұрын
I can not get over how simple you make everything. All of the information is there, I UNDERSTND IT. I am only passing biochem II because of you
@Obamnaz
2 жыл бұрын
Awesome explanation but complex III pumps 4 protons and complex IV pumps 2. Just wanted to clarify incase anyone was confused
@backstreetfan2887
3 жыл бұрын
Wow, I learn so much from these! Before I had no clue at all how the shuttle system for NADH worked.
@bingohara527
7 жыл бұрын
extremely helpful!!! understanding concepts like this makes me love biochemistry much much more!
@sitaraumar2333
Жыл бұрын
Nothing can be more crystal clear than this!! Hats off to u sir!👑❤️
@mdfersch
9 жыл бұрын
Outstanding lectures on all of glycolysis! Thank you!
@davev8347
2 жыл бұрын
This is perfection. I used this video for the mcat many years ago and now I have returned for 1st year.
@sama_albairmani
3 жыл бұрын
I don’t know how would I pass biochemistry exams without u.. you’re absolutely the best
@yaiburanakul8505
4 жыл бұрын
Thank you! You are very clear with your lecture!
@promisendlovu8550
8 жыл бұрын
thank you very much ,your efforts are highly appreciated !
@user-re8no8et6t
8 ай бұрын
am so grateful. this is so helpful. Thanks a lot
@227johnb718
5 жыл бұрын
You're a gem! A+ professor!
@aanalbhatt2444
8 жыл бұрын
amazing video! helped a lot, thank you!
@rohitsivananthan4423
Жыл бұрын
This video was really clarifying - thank you!
@Amar45611
6 ай бұрын
My new favorite teacher..Thank you so much for such an in-depth explanation Sir
@BorntoRock2010
7 жыл бұрын
Thank you Sir, for your effort in this amazing channel. I have Biochemistry final exam topics after 30h, so your work here is like emergency button for my revision session :)
@Happy_Queen369
Жыл бұрын
Thank you
@samad934
8 жыл бұрын
may god bless you.. these videos helped me a lot.. :)
@marshad.2257
4 жыл бұрын
You are excellent. Thank you.
@vitoriaradichewski4243
8 жыл бұрын
thank you !! Really helpful video
@MN-ox6yc
6 жыл бұрын
I can not thank you enough for saving my dumb ass. Didnt understand shit in the lecture, it's all SO easy now. Thank you so so much !!!!!
@fragrantbloom
8 жыл бұрын
thank you
@Dr.sleep-DNP
Жыл бұрын
note that helped me understand this for Biochem. Glyceraldehyde 3-phosphate (G3P) is an intermediary in glycolysis. Glycerol 3-phosphate is the reduced form of DHAP and participates in this shuttle system. G3P is not the same as glycerol 3-phosphate, I think that's an error in this video but I'm not nearly as well versed as Dr. Andrey so take that with a grain of salt.
@mpc7440
Жыл бұрын
Acronym for Glyceraldehyde 3-phosphate is usually GAP or GADP as opposed to G3P.
@rydersonthestorm7175
6 жыл бұрын
You're a beast! Thanks for explaining this better than my prof! Cheers!
@anetttet5262
7 жыл бұрын
you are my hero
@GoodbyeRubyTu3sday
7 жыл бұрын
THANK YOU!!!
@abdussalamkhan6564
6 жыл бұрын
Thank you sir ... it is very very helpful.
@bilgekaaner4436
3 жыл бұрын
thank you sir
@zohasadqat
6 жыл бұрын
Great!
@ashutoshbehera5603
2 жыл бұрын
Thanks 👍🙏
@bibiamina977
5 жыл бұрын
thankyou so much
@johannalapere1762
6 жыл бұрын
you are a hero! :)
@Micro-life
7 жыл бұрын
u r awsm.... bst lectures... thnk u sir
@angrant2014
5 жыл бұрын
Thank you very much for explaining this so well. Great job! I get it now. :-)
@user-hk3fu2wy1y
6 жыл бұрын
my professor is really good idk why i end up in youtube;) great exlapanation by the way
@amsd5780
2 жыл бұрын
Why didn't I find you sooner, you would have helped me so much early on T^T I have my exam in 1h30 and I feel somewhat ready, we'll see how it goes.
@lorizimmermann5188
3 жыл бұрын
I love your videos so much I watch them like a Netflix series lol
@kairosmagno8883
5 жыл бұрын
For clarification, in glycerol 3 phosphate shuttle.... can we simply change the main focus of electron carrier to FADH that produces 1.5 ATP instead of NADH? although its electron carrier originates in NADH from cytosol, but we can differentiate the NADH (electron carrier) from malate aspartate shuttle that produces 2.5 ATP for clear understanding of shuttle mechanism
@farihalghuznavi6982
8 жыл бұрын
OMG! Your lectures are the best. Thanks!
@mohammad.shokrolahi
6 жыл бұрын
thank you :)
@3moor97able
6 жыл бұрын
u r amazing
@Zetsuke4
4 жыл бұрын
very nice
@armyyyyyyyyyyyy
5 жыл бұрын
Thank you 😊😊😊😊😊😊😊
@parimakamal7980
4 жыл бұрын
Thank you so much sir🙏🙏🙏🙏
@USetareh
7 жыл бұрын
May You ONLY SEE BLESSINGS !!
@chiahsuantsauo8375
2 жыл бұрын
I never knew there was another enzyme within the mitochondrial membrane that was part of the ETC. I only figured something wasn't right when I read that you can get pyruvate from glycerol, and the google images gave me a whole another pathway I never seen before. I'm still kinda confused how this ties with glycerol and gluconeogenesis but I guess there's another video out there that will explain.
@stephanieoteyza3523
4 жыл бұрын
i would have given up so long ago if it weren't for these videos!!
@trungdoduy4959
5 жыл бұрын
I love you, thanks so ...much...
@bluepillow3005
2 жыл бұрын
you saved me!
@farzeenarshad384
Жыл бұрын
Superb lecture ❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤
@foreverpinky1
5 жыл бұрын
GOOD SHIT
@amruthamavily
6 жыл бұрын
thank yew sir
@yilkaladugna1453
5 жыл бұрын
nice video i am doctor(student) from Ethiopia
@ciarahugle2871
5 жыл бұрын
what are the similarities between the NADH molecules produced from the citric acid cycle and the NADH molecules produced from glycolysis and their electron transfer pathways?
@laibashuaib5132
11 ай бұрын
4 H+ are pumped out into intermembrane space at complex 3
@javi3r24
7 жыл бұрын
what a fucking boss you are sir
@lazytrip7292
8 жыл бұрын
isn't complex 3 pumping 4 protons into inter membrane space and complex 4 pumping 2 protons??
@IM-td9mj
8 жыл бұрын
you are right
@user-qd2fq2ng3g
8 жыл бұрын
+Rickson chelliah in complex 4 ,2 protons are pumpt out and 2 are conected to an o atom to make h2o. so 4 are used in total. and in complex 3 it dependens on how you consider the q coensime. it is a littel diffrent in every textbook. hopt it helpt. and sorry for my english, it is my therd language :{
@blakegammill5309
4 жыл бұрын
this video is fucking amazing
@keremyucel296
4 жыл бұрын
5:05 how are they isozymes if they catalyze reverse reactions? Shouldnt they do the same thing?
@user-kj1pn1sm1q
8 жыл бұрын
thank you sooooooo much im doctor (student) from great IRAQ
@MedEasyAnas
4 жыл бұрын
فضحتنا اسكت
@_mqm7
Жыл бұрын
طب بغداد ؟؟
@SmoDesign
7 жыл бұрын
until 8:00
@sashwattarenia258
4 жыл бұрын
so basically if glycolysis takes place in skeletal muscles then net atp produced is 5 and if it takes place in heart and liver then it is 7...right?
@nadiatunisie1
7 жыл бұрын
3 protons are required to synthesize 1 ATP i think not 4 protons
@RenewalFitCoach
2 жыл бұрын
I still have no idea what any of this means, but it's much clearer than reading a book haha :)
@GordonChao0508
3 жыл бұрын
Why there were 2H+ pumped out from Complex 3. How is the 2H+ formed?
@dalicolonel8722
8 жыл бұрын
i think complex 3 reject 4 H+ and complex 4 reject 2 H+ no?
@IneshKhanal
3 жыл бұрын
reject or eject? please clarify :)
@yuliyajoseph697
4 жыл бұрын
Thank you for all the videos! Just to clarify- I thought G3P was Glyceraldehyde -3 -phosphate?
@manjushreevani3813
3 жыл бұрын
Glyceraldehyde-3-phosphate = PGAL
@rashmimehta3272
4 жыл бұрын
What happens to NADH of link rxn and kreb cycle
@shvn769
3 ай бұрын
all good just one correction. the amount of H+ that are released by complex 3 is 4H+. please pin this comment so the everyone can recheck,
@vipulshirsat3644
2 жыл бұрын
💛💛💛
@dkastner
7 жыл бұрын
You are by far the best biochemistry teacher ever!
@hanadyhanadosha4890
8 жыл бұрын
I do not know how can I thank you
@DeceitfulDestiny
8 жыл бұрын
Donate a little, I did and highly recommend it. He's donation funded so it's worth it to show a li'l appreciation and keep his lessons afloat
@faraha2285
7 жыл бұрын
Why isn't there any ads on his videos?
@notnasaunofficial
Жыл бұрын
I think there would be 4 protons from complex 3 and 2 protons from complex 4
@elizabethrice-reynolds6585
7 жыл бұрын
Where does the FADH2 go once it is reduced (by the process of G3P being oxidized into DHAP)?
@abhishekkhersa9373
3 жыл бұрын
FAD+ is a prosthetic group of mitochondrial G-3-P, so when it gets reduced to FADH2, it transfers its H2 to ubiquinone(Q) to form QH2 and gets oxidized again to become FAD+
@user-mc4jx7sc5g
2 жыл бұрын
@@abhishekkhersa9373 you mean complex 3 receives electrons(or CoQH2) not only from complex1 and 2 but this way(CoQH 2 produced by FADH2)?
@stevenkatz1048
7 жыл бұрын
Shoutout to my Stony Brook Classmates
@zikrihaziq2557
4 жыл бұрын
3h+ = 1 atp or 4h+ one atp?
@JaLLaM86
3 жыл бұрын
Does anyone know how G3P may pass the outer mitochondrial membrane? I don't think it is specified in the video
@harirud1851
2 жыл бұрын
I had the very same question
@iolandasalvati2782
Жыл бұрын
@@harirud1851 Me too...
@shivagowda6788
5 жыл бұрын
Why complex 3 pumps only 2 Proton not 4 because other complex pump 4 Proton
@sugakick-3301
7 жыл бұрын
Can someone explain why one mole of glucose through the malate-aspartate shuttle generates 38 ATP while though the glycerol 3 phosphate shuttle only 36 ATP is generated?
@Zoem007
7 жыл бұрын
in Malate-aspartate shuttle the electrons are transferred to NAD+ making NADH in the matrix hence allowing NADH to go through complex I whereas in G3P shuttle it goes directly to Complex III bypassing I
@christoseconomos3856
Жыл бұрын
I thought Complex III pumps 4 H+ and Complex IV pumps 2 H+
@marvinbrightyoung2520
5 жыл бұрын
At 10min is proton not ATP to me
@angelademaio6291
7 жыл бұрын
Sorry but isn't G3P used to refer to glyceraldehyde 3P rather than to glycerol 3 P? Thanks in advance :)
@smaerDrM
7 жыл бұрын
no, it's GA3P glyceraldehyde, which is intermediate of the glycolysis, here G3P stands for glycerol 3P and is part of this shuttle, the only mistake in this lecture was about complex III pumps out 4 H+ whereas Complex IV pumps out only 2
@angelademaio6291
7 жыл бұрын
Thanks a lot :)
@adamzalaquett681
6 жыл бұрын
G3P and GA3P are BOTH abbreviations for glyceraldehyde 3-phosphate. It is clear in the video that he is talking about glycerol 3-phosphate and uses G3P as its abbreviation, however you are right, *by convention* G3P is a shorthand for the glycolysis intermediate, NOT glycerol 3-P.
@drmhm313
2 жыл бұрын
Legends are still watching thia video in december 2021 for preparing their exams Like MEEEEE
@gilbertateh5265
Жыл бұрын
Wait a minute... I thought it was 4, 4 and 2 not 4, 2, and 4 protons
@Danoroxursox13
7 жыл бұрын
Something minute, but your G3P structure should be CHOH rather than CH2OH, but awesome vid
@retooluvyuhx5569
3 жыл бұрын
Thank you sir
@user-kj1pn1sm1q
8 жыл бұрын
thank you sooooooo much im doctor (student) from great IRAQ
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