I started taking Glynac, taurine, berberine, and Methylene blue in 2024, when I was 63. I'm posting this from 2087. I'm now approaching 126 years old. It works! Headed for my weekend 50 mile bike ride!😊
@OswaldJames-x2t
7 ай бұрын
😂😂😂❤
@bebipin1957
7 ай бұрын
Time machines don’t exist🙀This is it!🙀🔜😸
@LanceHitchings
7 ай бұрын
LOL 😂
@leslietownsend6167
6 ай бұрын
🤣
@doncook5221
6 ай бұрын
Apparently it doesn't do much for mental health...
@LTPottenger
Жыл бұрын
Fasting can also do a great deal for your longevity! Taurine as well. Some benefits of doing occasional extended fasting: High blood pressure is lowered to normal levels very quickly while fasting. Fasting restores NAD+ to healthy levels. Vitamin D plasma levels are increased as fasting improves metabolic health, and vitamin D in turn increases autophagy. Fasting stimulates phagocytosis, the ingestion of bacteria, plaques and viruses by the immune system. It will also remove any 'foreign material' like spikes that are not supposed to be there. Whether natural or unnatural in origin.. Fibrosis/scarring is reversed over time. Fasting increases nitric oxide release. Blood clotting is reduced and blood clots and arterial plaque are reabsorbed into the body. Reflexes and short term memory are increased. Fasts from 36-96 h increase metabolic rate due to norepinephrine release! After 72 hours or more fasted, your body recycles up to 1/3 of all immune bodies, rejuvenating your entire immune system. This helps prevent the onset of new autoimmune conditions, which develop through a leaky gut and damaged immune system. Fasting can help with MS, Depression, BPD, Autism and seizures. Thymus is regenerated, which suppresses aging and renews the immune system. The thymus also plays a vital role in fighting cancer. Blood sugar and insulin are lowered when fasting, allowing white blood cells to move more freely throughout the body and do their job. Weight loss from daily caloric restriction has 1/4 to 1/3 of the weight lost as lean tissue while many studies show fat loss from 36 h fasts without losing any lean tissue! The obese will lose extra tissue like loose skin while fasting, but the skinny or frail will have increased growth hormone release than the obese, which helps to make more lean tissue and reduce frailness. The hunger hormone ghrelin also lowers with extended fasting and rises from dieting. When you move out of MTOR your body shuts down the building blocks of the cell required for viruses to replicate. What breaks a fast? Anything with protein or carbohydrates in it will break a fast. Most teas and herbs are OK. Most supplements and meds will either break ketosis directly or contain a filler that will. Many meds are dangerous to take while fasting. Does fasting lower testosterone? No, it raises it when the fast is broken by increasing lutenizing hormone. Fasting also increases insulin sensitivity, which helps with muscle building. Fasts of 36-96 will not affect short term female fertility or affect menstrual cycle. They also may increase long term fertility, especially in women with PCOS. Fasting reduces pain and anxiety by stimulating the endocannabinoid system in a similar way to CBD oil. Fasting very quickly reduces leptin resistance, which impairs immune function. One day of fasting can cut your leptin levels in half and gets your immune system working properly again! Stomach acid is reduced over time while fasting and can allow for the healing of treatment resistant ulcers. Some patients may need continued acid reduction medication while fasting. Does the body preferentially prefer glucose as a fuel? No. Except for brief periods of very intense exercise, your body mainly burns fats in the form of free fatty acids. Your brain also prefers to burn ketones at a rate of around 2.5 to 1 when they are available in equal quantity to glucose. Fasting stimulates the AMPK complex and activates autophagy. Autophagy (literally self eating) will cause cells to recycle foreign matter such as viruses and kill cancerous and senescent cells Lowering insulin via fasting virtually eliminates chronic inflammation in the body. It increases mitochondrial function and repairs mitichondrial DNA, leading to improved ATP production and oxygen efficiency. Increased mitochondrial function also has the added benefit of increasing your metabolism, fighting infection and cancer prevention! Fasting releases BDNF and NGF in the blood which stimulates new nerve and brain cell growth. This can help a great deal with diseases like MS, peripheral neuropathy and Alzheimers. When not in ketosis, the brain can only burn carbohydrate, which produces a great deal of damaging ROS the brain has to deal with. Fasting also increases telomere length, negating some of the effects of aging at a cellular level. When you fast, this stimulates apoptosis in senescent or genetically damaged cells, destroying them. Senescent cells are responsible for many of the effects of aging and are a root cause of the development of cancer. A fasting mimicking diet for 3-5 days in a row also provides many of the same benefits as water fasting. Exogenous ketones can aid with fasting, making it easier in healthy people and allowing some people with specific issues to fast in spite of them without worrying as much about hypoglycemia. Children, pregnant or nursing women should not fast for periods longer than 16 hours. People with pancreatic tumors or certain forms of hypoglycemia generally cannot fast at all. Type 1 diabetics can also fast but it is more complicated and should be approached with caution as it could lead to ketoacidosis. If you experience extreme symptoms of some kind, especially dizziness or tremors, then simply break the fast and seek advice. Resources: www.ncbi.nlm.nih.gov/pmc/articles/PMC5783752/ www.ncbi.nlm.nih.gov/pmc/articles/PMC6141719/ www.ncbi.nlm.nih.gov/pmc/articles/PMC7607739/ www.ncbi.nlm.nih.gov/pmc/articles/PMC3017674/ pubmed.ncbi.nlm.nih.gov/23408502/ pubmed.ncbi.nlm.nih.gov/20921964/ www.sciencedirect.com/science/article/pii/S0005272806000223 pubmed.ncbi.nlm.nih.gov/6859089/ www.ncbi.nlm.nih.gov/pubmed/10232622 www.clinicaltrials.gov/ct2/show/NCT04375657 pubmed.ncbi.nlm.nih.gov/31877297/ n.neurology.org/content/88/16_Supplement/P3.090 pubmed.ncbi.nlm.nih.gov/31890243/ pubmed.ncbi.nlm.nih.gov/2518860/ pubmed.ncbi.nlm.nih.gov/29727683/ www.collective-evolution.com/2017/05/16/study-shows-how-fasting-for-3-days-can-regenerate-your-entire-immune-system/ pubmed.ncbi.nlm.nih.gov/7714088/ www.cell.com/cell/fulltext/S0092-8674(19)30849-9 pubmed.ncbi.nlm.nih.gov/27569118/ www.sciencedirect.com/science/article/pii/S1931312809002832 www.ncbi.nlm.nih.gov/pmc/articles/PMC1413655/ www.ncbi.nlm.nih.gov/pmc/articles/PMC5783752/ www.arcjournals.org/pdfs/ijrsb/v3-i11/7.pdf www.ncbi.nlm.nih.gov/pubmed/25686106 pubmed.ncbi.nlm.nih.gov/21410865/ www.ncbi.nlm.nih.gov/gene/25712 pubmed.ncbi.nlm.nih.gov/23707514/ www.ncbi.nlm.nih.gov/pubmed/24905167 www.health.harvard.edu/heart-health/abundance-of-fructose-not-good-for-the-liver-heart www.ncbi.nlm.nih.gov/pmc/articles/PMC7093158/ clinical.diabetesjournals.org/content/36/3/217 www.ncbi.nlm.nih.gov/pubmed/23876457 www.ncbi.nlm.nih.gov/pmc/articles/PMC8470960/ pubmed.ncbi.nlm.nih.gov/25909219/ www.cell.com/molecular-cell/fulltext/S1097-2765(18)30605-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1097276518306051%3Fshowall%3Dtrue pubmed.ncbi.nlm.nih.gov/28235195/ www.ncbi.nlm.nih.gov/pmc/articles/PMC2815756/ www.nia.nih.gov/news/research-intermittent-fasting-shows-health-benefits medicalxpress.com/news/2022-10-treatment-pulmonary-fibrosis-focus-telomeres.html www.ncbi.nlm.nih.gov/pubmed/10859646 academic.oup.com/ajcn/article/81/1/69/4607679 www.amjmedsci.org/article/S0002-9629%2815%2900027-0/fulltext europepmc.org/article/MED/22402737?javascript_support=no onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2265.2005.02288.x www.nejm.org/doi/full/10.1056/NEJMoa012908 www.ncbi.nlm.nih.gov/pmc/articles/PMC6407435/ pubmed.ncbi.nlm.nih.gov/15522942/ faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2019.33.1_supplement.819.10 www.biorxiv.org/node/93305.full www.ncbi.nlm.nih.gov/pmc/articles/PMC5895342/ www.ncbi.nlm.nih.gov/pmc/articles/PMC6526871/ www.cell.com/cell-metabolism/abstract/S1550-4131(15)00224-7 repository.upenn.edu/cgi/viewcontent.cgi?article=1537&context=edissertations www.ncbi.nlm.nih.gov/pmc/articles/PMC1779438/ www.nejm.org/doi/full/10.1056/NEJMc2001176 pubmed.ncbi.nlm.nih.gov/20102774/ This list compiled over years of research by the user known as Pottenger's Human on youtube but feel free to copy and paste this anywhere you like, no accreditation needed! My channel will always contain an updated version of this list of fasting benefits on the community tab. I also have playlists on fasting and health topics.
@venom999333
Жыл бұрын
The single GREATEST comment I have ever read 🫡👍
@LTPottenger
Жыл бұрын
@@venom999333 Thank you so much!
@teddybearroosevelt1847
Жыл бұрын
He has his own channel and has worked for years to accumulate all the info in this comment
@torkjoy1
Жыл бұрын
Wow, this is by far the longest and most informative comment I ever read, and I read it to completion. Thank you very much.
@LTPottenger
Жыл бұрын
I'm so glad you found it interesting. Fasting has had amazing effects in my life! @@torkjoy1
@tracyau9122
Жыл бұрын
I've been listening to a few youtubes on the glynac and you have given by far the best and most easy to understand explanation. thankyou!
@LanceHitchings
Жыл бұрын
You're very welcome! Being a little late to the table gives me time to figure out how it all ties together. Or, at least, my take on all that.
@creightonfreeman8059
Жыл бұрын
If my memory is correct on biochem pathways, L-Cysteine is used to make Taurine, so by taking Taurine along with the Glycine and NAC, you are reducing the chances of a lot of NAC being shuttled into the Taurine synthesis pathway rather than being used to make Glutathione Peroxidase. That is why I take all three amino acids at the same time, since I'm going to take the Taurine sometime given the recent evidence on its life extension benefits.
@bryanutility9609
Жыл бұрын
Does taurine affect sleep?
@theancientsancients1769
Жыл бұрын
@@bryanutility9609Most supplements should be taken during the day anyways unless it's magnesium etc which help relax muscles
@guravi4295
Жыл бұрын
not that i've noticed@@bryanutility9609
@geekermeister6322
Жыл бұрын
@@bryanutility9609positively
@monnoo8221
11 ай бұрын
there is way more cysteine than taurine begin produced. way way more. hence your argument is purely theoretical, not relevant for practical physiology
@mike7920
Жыл бұрын
Most comprehensive synthesis of the chemistry and data on this topic anywhere. Excellent
@kmjdebay
Жыл бұрын
Good review! I have been taking NAC for over 20 years to thin the mucus in my bronchi. I started at a doctor's recommendation after a severe, protracted viral bronchitis. I have usually purchased from Swanson. I see that their Glycine is available in capsules and powder...very cheap, especially when a sale is on. They use aminos from Ajipure, developed by Ajinomoto in Japan, a leader in amino development. "For more than a century, Ajinomoto Co., Inc. has pioneered the development of new and innovative technologies used to manufacture and purify pharmaceutical grade amino acids." I usually only take 600-1200mg daily, with no side effects other than breathing better. I will try increasing with these new doses. I've ordered the glycine, but have not received it yet.
@bryanutility9609
Жыл бұрын
Glycine powder tastes like sugar. I put a teaspoon in a shot glass of water and drinks the rinse because it doesn’t fully dissolve.
@timwilliams9100
Жыл бұрын
just took my Nac and Glycine before bed also take GABA and find that in just a few minutes I can feel my mind calming down and It really helps with Sleep
@Viv8ldi
Ай бұрын
How much gaba do u take? I was afraid it might be too much to take gaba and glycine
@bugsy1254
Жыл бұрын
Glycine powder from Bulk Nutrients $39.00 AUD for 1 kilograms (1000 grams). NAC powder $30.00 AUD for 250 grams. Taurine $44.00 1 kilogram. These are cheap to produce and too many companies are ripping off consumers.
@happyarmadillo4523
Жыл бұрын
Get taurine and glycine powder, so much cheaper. A teaspoon of glycine or taurine is about 4 g. And glycine powder is sweet tasting, so I switched out sugar and artificial sweeteners in my tea or coffee for glycine.
@LanceHitchings
Жыл бұрын
That's an awesome strategy.
@cizagui
Жыл бұрын
Excellent video. Thanks. Regarding your question about taurine: There are several differences between GlyNAC and taurine. Among them: - Cardiovascular Health: Taurine has been studied for its role in heart health. It helps maintain the integrity of cell membranes, modulates calcium signalling, and possesses antioxidant properties, all of which are critical for cardiovascular function. Some studies suggest it might be beneficial for conditions like congestive heart failure, hypertension, and ischemic heart disease. - Eyes and Vision: Taurine is essential for the retina, particularly for the photoreceptor cells. A taurine deficiency can lead to retinal degeneration and vision problems. Although both improve mitochondrial function, taurine has a wider range of metabolic paths to do that.
@StephenB_IndependentThought
Жыл бұрын
Thanks for the thorough explanations which help clarify the relationships of these aminos and precursors. I take 3g Taurine, 2g NAC, 4g Glycine, 2g Collagen, 1g Glutathoinne every Other day , because I take so many supplements (about 57 cycled over 3 days), and want to be careful of liver issues and toxicity. I'm 67 year old chronological and 56 biological according to latest Elysium DNA methylation test. Younger kids don't believe my age when I tell them, which is fun. But I cant't seem to break that 11 year difference and my goal is a15 year delta. Body fat is19% but could be better. Blood work is good to very good, but not excellent. I attribute most of my longevity however to intense 4 day aweek 2 hours HIIT and weight training. A very good but not great diet. So far, so good. I'm waiting on human trials of Rapamycin.
@LanceHitchings
Жыл бұрын
I agree. While taking supplements is great, I think I get the most bang for the buck from exercise.
@jorgeluisrodrigues1322
Жыл бұрын
I'm on intermittent fasting over 35 years approximately.i'm61.The photo on the side is current.
@troecurov3
Жыл бұрын
@@jorgeluisrodrigues1322Ho Jorge, I was wondering if you could kindly share what you foin terms of diet, what's your fasting as well... Regards Andrei
@onaraider2007
Жыл бұрын
How are you being careful about liver toxicity?
@monnoo8221
11 ай бұрын
glutathione (GSH) does not survive the stomach and the intestine, and it does t get taken up as such. It is too big and kind of a mini peptide. NAC is its rate limiting precursor and is transferred into the system. supplementing with glynac has been shown to increase GSH
@jefflittle8913
Жыл бұрын
From my perspective the real benefit of combining taurine and NAC is that NAC can be cannibalized to deal with taurine shortages so adding taurine could provide a buffer against that. Also Glycine and taurine probably both have extremely high ld-50s (unlimited?) whereas we don't know as much about NAC dosage size. But I am not aware of any studies confirming this. By the way, it is worth noting that NAC has three meanings NA Cysteine (glutathione), NA carnosine (used in protective eye drops), and NA carnitine (body-building supplement?)
@bryanutility9609
Жыл бұрын
NAC means N-acetylcysine only. Any other substance is something else entirely.
@kevingold1091
Жыл бұрын
I would add that TMG can and does neutralize homocysteine. I've been taking TMG for years, eat a diet that I expect is quite high in methionine, and yet my homocysteine number always test very low. That won't stop me from adding glycine -- it's been on my radar for a while -- and I've been taking NAC for years too. Keep up the great work!
@robert111k
Жыл бұрын
But TMG (that can be a life savior for those who have genetic problems with methylation) the only thing It does is converting homocysteine back into methyonine. And having an excess of that amino acid circulating can also be dangerous.
@LanceHitchings
Жыл бұрын
TMG also helps out if you're taking NMN or NR.
@trevormallett750
Жыл бұрын
Good video sir, thank you :)
@monnoo8221
Жыл бұрын
@@robert111k the amounts matter... Homocysteine is less abundant than methionine, by a factor of 3. Yet I admit that nutrition wise there should be days with little protein supply in order to encourage recycling, and helping out with stoichiometry. Furthermore, the availability of TMG is not the only factor influencing the methionine\Hcys metabolism
@ticketforlife2103
Жыл бұрын
How are your liver's enzymes? I hear that NAC damages the liver
@driggerfireon5760
Жыл бұрын
Definitely separate. Always do that. Again great job in dose details- studies dosing and recommendations. You doing great job.
@LanceHitchings
Жыл бұрын
Thank you!
@stevec5375
Жыл бұрын
I would love to get an accurate dosage for the items mentioned in this video. I am taking NAC, Cysteine, l-carnitine, l-proline, D-Ribose but I have no idea what the proper amount to take is. I'm probably too low because I am concerned about overdoing it and causing some kind of systemic toxicity.
@joeblow2183
Жыл бұрын
Very nice report! The big 3.
@LanceHitchings
Жыл бұрын
Thanks.
@shaggyman8564
Жыл бұрын
As an MD I felt I was back at Med school. VG presentation. Separate sups for sure. One thing I may add is to take these aminos on empty stomach. Sub and like.
@monnoo8221
Жыл бұрын
about taurine. you said, it does pretty much the same thing as GSH. (@17:00). No it does not, it is in a completely different metabolic context. For instance, it enhances beta-oxidation of fatty acids, modulates cellular calcium, protects against glutamate-induced mitochondrial damage, increases NO, protects kidneys via decreased creatinine, improves mitochondrial metabolism (cytC etc) and thus reduces oxidative stress. GSH on the other hand, is "just"acting on\scavenging the ROS directly... I think this is not exactly "pretty much the same". cheers for an otherwise very good presentation! :)) as for the recommendation, I value them a bit exaggerated. My motto is always "help the body to self-help itself", and flooding it with any component in high dose is nothing else than messing around with the metabolic network.
@LanceHitchings
Жыл бұрын
I stand corrected. Not being a doctor or a biologist, I'm still trying to figure this all out. A big part of my continuing education comes from the comments I get on this channel. Thanks.
@SpinStar1956
Жыл бұрын
What I really think you should recommend is the individual powders. First off, the y are hugely cheaper than capsules and allow the supplementation to be at a much higher level for a lower cost. Yes, you do have to learn how to measure grams or milligrams, and you may even want to put them in you own capsules. What I do is measure out the doses and combine them in a small amount of water to swallow them; I then chase it with a normal glass of water. In the beginning, I used a scale and paid (because each one weighs different with volume) attention to the physical amount. Now, I just pour out each one without weighing; however, I do occasionally check with a scale to see how close I am. And, with these, your really not concerned with overdose, if you are midrange supplementing...
@seaspray9144
11 ай бұрын
What proportions are you using please? And are you taking the Taurine too?
@SpinStar1956
11 ай бұрын
@@seaspray9144 600mg of each, twice a day, usually on an empty stomach. Taurine and L-Theanine 500mg each, one to two times a day, no special time or condition…
@tomjones2348
Жыл бұрын
Subscribed! Before watching your video I said to myself, I know quite a bit about this subject and have been taking these sups for years...BUT, lets see if there's something that I didn't know or haven't read anywhere before. I'm 66, in superb fitness and health, and take 3 grams of NAC in 3 doses per day. I take 2 grams of Glycine with a gram of Myo-inositol before bed. I also do 3 grams of taurine during the day. Great presentation. I'd like to hear more about dosing/time/amount.
@larsnystrom6698
Жыл бұрын
You should get Glycine as a powder. It's much cheaper than in capsules. And you can utilize it as a sweetener in many things. Since you probably will use much more Glycine than NAC or Taurine, that reduces the amount of capsules you have to swallow substantially.
@richardcabeza9596
Жыл бұрын
I just put a spoonful in my mouth and wash it down with a drink. It is sweet so it goes down easily.
@karlfillmore57
Жыл бұрын
Or just take some powdered collagen which is loaded with Glycine.
@assumedpatriot8182
Жыл бұрын
Upon your suggestion, I looked at my 2 Collagen supplements. I'm getting about 2G in 1 supplement, and 1.5G in the other. I take a Glycine supplement of 3G / day. Along with the 5G my body produces, that's about 11.5G; not to mention my healthy diet's contribution. I love Siim Land, but I think about 15G of Glycine should do it for me, for now. I'm 68 y/o this year and feel in top physical and health condition. Anyways, thanks for the head's up that my Collagen supplements also contain Glycine. @@karlfillmore57
@franklebatista1091
Жыл бұрын
Great, ant specific brand to recommend. I'd appreciate it.
@phil-spinelli
Жыл бұрын
yes, and you can make your own capsules too. get empty capsules and one of those basic capsule machines like "the capsule machine"
@ManfredBartz
Жыл бұрын
Many of us are already taking trimethylglycine (TMG). How would TMG factor in with NAC (and taurine)?
@evelynmelian-glick436
9 ай бұрын
Thank you for this great and well explained video!
@KayFlowidity
10 ай бұрын
7:45 Glutathione 12:00 Ratios 13:00 Studies
@groovycarter
Жыл бұрын
Great video I would like to hear more about side effects and competing amino acids ingested either before or after taking glynac and taurine. Glycine (1 gram) taken in the morning produces an excitatory feeling in me and taking glycine at night makes me restless. Taurine produces a relaxing effect but seems to give me mild headaches.
@bryanutility9609
Жыл бұрын
Glycine is supposed to induce GABA & melatonin levels before bed. It improves dreams, increases drowsiness. Maybe you are odd in some way or taking something else.
@johngibson7693
Жыл бұрын
Why add Taurine to nac and Glycine? You said yourself later in the video. It's cheaper to buy separately. I.E. more profitable for the seller to sell together. + marketing and convenience. I now buy Taurine and glycine in powder form, which is even cheaper than the separate capsules and has more leeway on dosing. I bought small measuring spoons at the $ store. Another great video by the way.
@montypalmer4556
Жыл бұрын
Nuchido, they have interesting data. I put my own version together and I feel encouraged.
@emmettmurphy1
Жыл бұрын
glynac and taurine!
@LastTrump7
Жыл бұрын
Taurine cancer study risk?
@michaelsteven1090
Жыл бұрын
Yes, take all 3 at night before bed..add in some relora for best sleep!
@fredzander834
Жыл бұрын
What worked best, the P shot or the PT 141 option.
@bryanutility9609
Жыл бұрын
@@fredzander834can you elaborate?
@billw6903
Жыл бұрын
Yes all 3
@sgtaneja
4 ай бұрын
This is utter Rubbish ! In any longevity trial, longevity can only be ascertained provided atleast the following conditions are met : 1. The subjects being studied have already aged considerably or have premature accelerated aging prior to the trial. 2. The drug / neuraceutical is being administered medium to long term to assess the "longevity" effects over a reasonable observation time period - typically several months. 3. All other physiological and environmental parameters, including age group, demographics, genetic markup, diet and food intake, physical activity, sleep patterns, stress patterns etc are near identical during the trial. 4. The detailed list of specific clinical and sub-clinical physiological, pathological, and metabolic markers are cross referenced for all the participating subjects at periodic intervals.
@billkipper3264
Жыл бұрын
I bought all three supplements in powder form and weigh out my doses each day. Currently, I'm taking 10 grams of Glycine and 4 grams of NAC split morning and night. Taurine I'm taking one gram per day.
@LanceHitchings
Жыл бұрын
Keep it up. I like to hear other's personal protocols.
@ticketforlife2103
Жыл бұрын
4 grams of NAC? that's crazy high, do you watch out for your liver?
@CB-wq9wp
Жыл бұрын
If you don't mind me asking - how long have you been taking those dosages, and what benefits have you experienced?
@larryc1616
8 ай бұрын
More taurine and less NAC in your stack
@mitchellbjerke272
Жыл бұрын
I’m on day 14 of Glynac dosed for my body weight as I read in the study you mentioned. If I calculated right I am 190 pounds and take 12 grams NAC, 9 grams Glycine. Both are powders. I drink it in sparkling water. The study said 12 days not 16 weeks. Was done at the Translational Metabolism Unit at Baylor in Houston, Texas 2021.
@bryanutility9609
Жыл бұрын
That’s a crazy amount of supplement powder. I take 1G of NAC max & glycine ~3g before bed.
@snave59
11 ай бұрын
mitchellbjerke.That is an insane amount of glycine and NAC.600mg,of each twice a day,is plenty.
@bryanutility9609
11 ай бұрын
@@snave59 even that much if you’re sick.
@seaspray9144
11 ай бұрын
How are you doing now?
@larryc1616
8 ай бұрын
Too much NAC is not good
@seaspray9144
11 ай бұрын
Please give us some idea what proportions to mix the NAC and glycine together - some of us don't have a clue Lance!
@LanceHitchings
10 ай бұрын
Each of us need to figure out what the right amount is for each of us. Here's what I would use as a rule of thumb. 3 G for glutathione synthesis. 12 G for collagen synthesis. Minus however much you get from your diet. That's for glycine. I'd day about 3 G of NAC, minus what you get in your diet. Both of those are minimums. Both are considered safe up at doses of over 50 G a day.
@filipkamban
Жыл бұрын
Awersome! Thank you!
@DM-jt4rh
Жыл бұрын
Just it clarify - the humam study you referenced the dosage was 100mg/kg body weight so roughly 8 g EACH of glycine and NAC for an 80kg /175lb individual correct?
@glenntimberlake2413
3 ай бұрын
Seems way too high for NAC.. about 1200 mg 2-3 times per day would be plenty… some would say a lot. Currently I do 1200 mg NAC in AM about 30 or more minutes prior to breakfast. I have coffee with cream afterwards. . All that is after I have 20 oz. Of water with a whole lemon squeezed into it. Currently I have my Glycine a little later. Trying to get my gut to be happy with all the stuff I take. I have other supplements I take before breakfast. Includes Magnesium glycinate (glycine in that). MSM, zinc, l-lysine, acetyl L carnitine. . And a few more after breakfast.
@johnallen7230
Жыл бұрын
Please consider flexing your amazing intellect on an analysis of Sermoreline. Please include the various means of delivery into the body ie. injections, nasal, etc.... Thank you in advance for your due consideration to the aforementioned request. Respectful Regards, John Aging Stack-Bedtime: Glycine 1300mg (2 pills) NAC 1300mg (2 pills) Taurine 3000mg (3 pills) Sermoreline (nasel spray 2 pumps each nostril)
@bernardedwards8461
10 ай бұрын
You should have mentioned that although you look 60, you're actually 123!
@pmstff700
Жыл бұрын
Nathan Patel has a patron on a transdermal topical glutathione. His book The Glutathione Revolution is fantastic at explaining this. Also quick silver scientific has a good glutathione sublingual in a lipo form too.
@LanceHitchings
Жыл бұрын
If you want to take glutathione, be my guest. But if it were me, I'd stay away from glutathione, ESPECIALLY liposomal glutathione, and instead let the individual cells synthesize as much glutathione as they need.
@monnoo8221
Жыл бұрын
not a good idea, even if there is someone praising it
@Always-xl9db
Жыл бұрын
Same for IV glutathione?
@monnoo8221
Жыл бұрын
@@Always-xl9db yes, absolutely
@Painreliefcenter949
10 ай бұрын
The glutathione molecule is not absorbed by the cells very well if at all. It has to be made inside the cell. Lack of cysteine absorption is the cause.
@lindacgrace2973
Жыл бұрын
Separate! First, it is cheaper. Second, it's more personalised and customisable. Thanks so much for the dosing information!
@LanceHitchings
Жыл бұрын
Totally agree!
@olveaustlid4383
Жыл бұрын
Taurine is produced by the body, but in diminishing amounts as we age. Moreover, cysteine is a source of taurine production. But, if cysteine is spent using gluthathione, simply because all the other ingredients just became more readily available due to the supplements, taurine production will suffer more. So thats why taking taurine is used: To make up for the greater spenditure of cysteine to make gluthatione. Or thats my theory anyways.
@LanceHitchings
Жыл бұрын
That makes sense. Thanks. I was wondering.
@arnabsingha114
Жыл бұрын
Amazing representation, I am just surprised to see how precise and informative is this video, keep it up man 😊.
@Niksky2
Жыл бұрын
Try to boil potato in a pot and put it aside, cover your head with towel and breath this vapor before shooting the video - this will soften your voice - this is Russian recipe works well for lungs cleaning and voice softening,
@LanceHitchings
Жыл бұрын
Interesting. I might try that. I've always had a very gravelly voice, all my life.
@stefanweilhartner4415
Жыл бұрын
i have these substances in powder form and mix them together in water. i use different mixtures in the morning and evening. in the evening glycien + taurin + magnesium because of their relaxing property. nac and msm and maybe creatine, inositol or methylene blue in the morning.
@LanceHitchings
Жыл бұрын
Just our of curiosity, what do you think of methylene blue? I've been thinking of adding it to my regime, but haven't decided yet.
@stefanweilhartner4415
Жыл бұрын
@@LanceHitchings i think it gives me more focus
@EldanSai
Жыл бұрын
Hi, Can you address research linking NAC to cancer growth? I suppose the dosage matters quite a bit, but I want to make sure NAC is safe to consume, thank you!
@bryanutility9609
Жыл бұрын
It does not induce cancer. It’s totally safe and comes from food generally.
@Tner0lf
Жыл бұрын
Glycine in the evening to help with sleep and nac on empty stomach first thing in the morning for absorption. I combine nac in the morning with ala
@robbertag808
Жыл бұрын
That's not cheap, lmao. I get my Glycine 500 grams for $ 13. NAC 200 grams for $11.
@larryc1616
8 ай бұрын
Fake from scam brands
@robbertag808
8 ай бұрын
@@larryc1616 Yeah, great. You know nothing about which brand I buy, so how can you say it's fake? Lmao.
@davidgifford8112
Жыл бұрын
This is an information pact video, as usual, lots to think about again. While I do use Life Extension products, I’m less enthusiastic about their combined products that often contain substances I don’t require. I also agree that being able to titrate your own dosage for each molecule is the way to go.
@zamfirtoth6441
Жыл бұрын
Both are highly abundant in animal based foods, spending hard earned money on a plastic bottle of synthesized versions is throwing money in a hole, and benefits the seller and MLM structure only. Taking these substances in much higher concentrations than nature provides is completely experimental at this point. You are spending money, and being a lab rat.
@eviejared9055
6 ай бұрын
The most comprehensive, most concise, interesting explanation available on KZitem I swear! Thank you so much!
@LanceHitchings
6 ай бұрын
Wow, thanks!
@hove785
Жыл бұрын
excellent thanks
@ChillFantasticFive
Жыл бұрын
Where did you find the slide that 36g was needed for optimal collagen turnover. That is huge. I've been taking 10g of glycine
@HufflepuffDaddy
11 ай бұрын
The slide is from the book The Collagen Cure by Siim Land
@GeneticsLessons
Жыл бұрын
I just checked old videos 4 years ago - you look younger than now, but 2 years ago about the same as now.. Does it prove that any therapies or procedures or nutrients you take work? May be or may be not because people in this age may stay the same for a decade without any visible appearance change.. But change in blood tests and other physiological test you took is a good sign - but again this all can be attributed to your change in died, lost weight and healthy food and regime.
@andriyurenov7215
Жыл бұрын
the voice doesn't sound right. you need to reduce the low frequencies and add the upper mids. it will make information perception much better. and the musical interruptions are too loud
@martinsinclair55
4 ай бұрын
Can GlyNAC raise BP? Mine has gone way up since I started using it😢.
@driggerfireon5760
Жыл бұрын
8 grams of glynac 4/4 grams . Hefty dose
@bobpeticolas121
Жыл бұрын
Although Glycine and NAC are certainly promising, I would be careful of the very high doses of NAC recommended. Either (and certainly both) can impair blood clotting, so high levels could cause a bleed.
@philsorensen6277
Ай бұрын
Interesting... I went off TRT due to health issues. As a result, I lost quite a lot of bodily fluid- puffiness. After six month on Glynac the muscle mass growth continues without the puffiness. Skin is very smooth and wrinkles have virtually disappeared. I'M SOLD!
@Viv8ldi
7 ай бұрын
Can I take glycine during the day too? Like maybe instead of ashwaganda?
@thea-listtv312
10 ай бұрын
Thanks for this. Q-- should I still take Glycine with NAC though I already take Magnesium 'Glycinate'? make sense? thanks in advance hope to get an answer from you. keep it up
@midnightflyer7510
9 ай бұрын
I do as well but I suspect the glycine in the Mg supplement is much too low to meet the 15g daily requirement. I’m not sure what the dosage is of glycine in my current magnesium glycinate supplement but I’m pretty sure it’s not that much. Good question though.
@theyareherewithus2944
8 ай бұрын
I buy them separately and have for several years so I can adjust to my needs.
@BfSkinnerPunk
Жыл бұрын
It appears that collagen peptides....the powder that many people buy for skin/hair/joints....has plenty of glycine in it. So, if taking that already, you only need the NAC. correct?
@HufflepuffDaddy
Жыл бұрын
Depending on info sources, collagen is made up of 20-33% glycine so you may have to adjust your collagen dosage to get the amount you desire...or just get glycine separately and add it to your program.
@BfSkinnerPunk
Жыл бұрын
Ah, well...I thought that collagen had more than enough glycine to satisfy this task. My current collagen stuff has 2,000mg Glyc per serving. I'd think ...hope...that that is more than sufficient for the NAC that's going down my pipe at the same time.@@HufflepuffDaddy
@SyriusStarMultimedia
Жыл бұрын
Glycine and NAC made news in the 1990s and were hot sellers for the exact same reasons except you had to read about them in muscle magazines. Is time repeating itself or am I on The Twilight Zone?
@LanceHitchings
Жыл бұрын
I don't remember that glycine and NAC were recommended for longevity in the 90s.
@virtualoutburst6873
5 ай бұрын
Did you say 50-60Grams of NAC? All the supplements I’m finding are around 600 mg.
@timbuck2-pv4ce
Жыл бұрын
Serious question. Since l-cysteine is also a building block of glutathione and is less expensive than NAC why not pair glycine + l-cysteine?
@monnoo8221
Жыл бұрын
reasons: NAC is better soluble, l-cysteine is a free amino acid directly available and should not be taken in high doses, as it can cause serious imbalances,
@Always-xl9db
Жыл бұрын
U can also take L-Serine with NAC as glycine and cysteine precursor because it reduces plasma homocysteine
@MindBodyStudio
Жыл бұрын
I take NAC with my collagen supplemnt. Collagen consists of about 33% glycene and I take 10 grams of collagen, so I feel no need for extra glycene.
@LanceHitchings
Жыл бұрын
Personally, I'm not willing to sacrifice collagen production for the purpose of obtaining glycine. I need all the collagen I can produce.
@nvrancher
Ай бұрын
Taurine, creatine, glycine, nac and collagen peptides with resistance training is a fountain of youth, after 50.
@Viv8ldi
Ай бұрын
Is it possible to overdose glycine? Like when I take 3x10g a day?
@shamster7182
5 ай бұрын
Nac 15 to 60 grams!? Lethal dose is 100 grams, should not take more than 3gm per day
@ticketforlife2103
Жыл бұрын
I only keep seeing that NAC can damage your liver. What do you think?
@Viv8ldi
7 ай бұрын
Memo: we moose about 10 percent of collagene after the age of 30, 10% per decade
@unholyquail4560
Жыл бұрын
Hello Lancem Personally only 33 year old (tested 27 on my demethylation test). My DNA profiel shows I would have beneficial effects from taking Glycine and NAC so I am adding those to my stack. Though for my age I will probably just aim for the low daily number DoNotAge uses and hopefully the demand due to decay for higher numbers staya away for a long while so I will not have to change the dosages. Homocysteine is a problem for people with a high animal product based diet where in Plant based people homocysteine in general is not found to be in the problematic zones. Ofcourse adding B12 to my diet is mandatory as a supplement (or in fortified foods). That is the tradeoff there.
@LanceHitchings
Жыл бұрын
Keep up the good work. Looks like you got it pretty dialed in.
@savvy.shane.1
Жыл бұрын
Good information. How does NMN relate to NAC, Glycine, and Taurine? Should we also be including NMN in our daily vitamin regimen?
@LanceHitchings
Жыл бұрын
Great question, I don't know. I know of no studies looking into this. If you hear of any, let me know. I'll do a video.
@maschoff69
Жыл бұрын
Taurine and glycine are used to conjugate bile for detoxification.
@DM-jt4rh
Жыл бұрын
One of THE best videos on glynac I have seen to date- nice work!
@LanceHitchings
Жыл бұрын
Seems like I'm always a little late, but the extra time really helps with the research and getting the relationships works out. Thanks!
@2tennhills
3 ай бұрын
What about reports that Glycine can cause cancer????😂😂😂
@TwinMillMC
4 ай бұрын
Great informative video but your voice sounds very muffled.
@ivanandreevich8568
Жыл бұрын
Not sure how humans evolved to need this amount of glycine per day. That's a stupendous amount.
@peamutbubber
Жыл бұрын
Because we ate natural meat which is rich in taurine and glycine unlike cooked modern foods
@viracocha2021
Жыл бұрын
Until 30 years old you don't need to supplement anything, we are talking about restoring to youthful levels. So no, our diets didn't need all the supplements you take with 50 years of age.
@Bass.Player
Жыл бұрын
@@peamutbubber the earliest evidence of cooked food was around 170,000 years ago
@monnoo8221
Жыл бұрын
we did not evolve to be older than 40y. We are tricking biology, and cultural evolution is reducing the direct impact of natural evolution. The best indication of that is the huge variety in body sizes. No other animal is showing that variability. Precisely because selection pressure does not allow for that variation in the latter, while for us biological\physiological selection pressure is strongly reduced.
@octaviano1296
Жыл бұрын
In the paleolithic era human beings cooked the bones and ate the skin and organs. Moreover, what is optimal for us is not the same as what was the bare minimum to survive long enough to reproduce. If - let's say 12 grams of glycine - has more benefits than lower dosage it doesn't matter if a bunch of generations were able to survive with less. It is all about optimalisation, not about minimum requirements.
@coronabuster3611
4 ай бұрын
Just started Glycine & NAC, oh my, NAC is disgusting. The dosages are so large I went for powders, I'm going to suck it up but yuck. Hope it makes me feel better. Ok, 2 days later I feel sick 24 hours a day, I think from the NAC. Has anyone else checked out dosages, he says 15-60gms but I can't find that, I suppose I'm hoping a lighter dose will be effective and I won't feel so sick. Granted, the rest of his information has all been right on the money. I'm just hoping maybe he meant mg instead of gms.
@Viertelfranzose
2 ай бұрын
For luck I can Glycin...5Kg for 65 Euro 😀
@pulkitsinghal7186
Жыл бұрын
So young people should not take Glynac? Is it impactful for young people?
@elbozi
Жыл бұрын
Your voice is sounding stronger
@EduardQualls
9 ай бұрын
*methionine [ me-'thahy-uh-neen ] / mɛˈθaɪ əˌnin, -nɪn /* _Anyone who wants to be an expert in something should at least learn to pronounce the topics in that field._
@LanceHitchings
9 ай бұрын
Not an expert. Never claimed to be. Just sharing what I've learned.
@joelarpin473
4 ай бұрын
15-60 g/day of NAC??? Do you mean mg?
@danh5637
6 ай бұрын
Really ignore anything David Sinclair says.
@idiotsavant53
5 ай бұрын
I go to Amazon and buy one kilogram (1000 grams) of NAC, Glycine and Taurine. I have an electronic scale that measures in tenths of a gram. I take 4 grams of NAC and 4 grams of Glycine to make 8 grams of GlyNAC. I also take 2 grams of taurine. Today is week 11 of GlyNAC supplementation and week 5 of taurine supplementation. I also take 20 grams additional of glycine daily. I had one young guy say to me that I was moving quicker. Practically "running" he said.
@panagenesis2695
Жыл бұрын
Don't forget Apegenin and Quercetin!
@44mickd
9 ай бұрын
Awesome video brother, thank you.
@Akashic09
7 ай бұрын
If we want a balance of ROS and Glutathione would the scavenging of ROS by Methylene Blue disrupt this balance?
@atelier27
Жыл бұрын
and can you take too much glycine? and to what effect? anyone. thanks
@HufflepuffDaddy
Жыл бұрын
5:40
@carvesnow
Жыл бұрын
Meth-i-o-nine
@benmcavoy8674
Жыл бұрын
I have been drinking 1g of Glycine and 1g of NAC powder with water every day. I find it disgusting and can't see how one could have 5- 10g of this stuff, yuk
@2coryman
2 ай бұрын
I believe the separate supplements may have the added benefit of no letting the body to only rely on supplementation, alternation keeps the body functioning better❤❤
@popothebright
Жыл бұрын
At the 3:19 mark, do you mean "Glycerin"? Or "glycine". You say "Glycerin" a vew times. But the chart says "Glycine"... ?
@dinomiles7999
Жыл бұрын
Bryan Johnson Blueprint, Ai will soon take the guess work out of it and all gurus and snake oil salesmen will soon be gone. Don't die, see you in 2500
@Viv8ldi
Ай бұрын
Memo: we start to loose collagen after the age of 30
@johngibson7693
11 ай бұрын
Thought you did a great job walking us through this. Use your video to show my girlfriend because of how clearly you presented it. I would only add when talking about the cost. Vast majority of amino acids come from China. So you have to make sure where they are sourced and or if they are third-party tested. Not something to just buy the cheapest.
@LanceHitchings
10 ай бұрын
Couldn't agree more. Thanks for bringing that up.
@patriciaquintela899
8 ай бұрын
If you already take a good collagen supplement , do you really need to supplement with more glycine when you introduce NAC? Another way to get taurine is with you magnesium- magnesium taurate.
@midnightflyer7510
9 ай бұрын
Any thoughts on NAC causing anhedonia, leading to a lack of pleasure and enjoyment in activities, even when combined with stimulants like coffee, alcohol, and cocaine? Was unaware of this until I saw a video yesterday on it and subsequently did a little further research on the subject.
@amanch9085
Жыл бұрын
Hi.. I couldn't find glycine in my country. So can I use NAC alone? Reply please
@LanceHitchings
Жыл бұрын
Sure, you can take NAC alone, but it's not going to produce the same results. Could you order it from another country and have it shipped?
@amanch9085
Жыл бұрын
@@LanceHitchings Thankyou for response❤ I will try to get it online.
@daleval2182
3 ай бұрын
I'm fighting cancer using a highly restricted sugar, it has a sweet taste, wonder if cancer could use it like glucose?
@LanceHitchings
3 ай бұрын
I have no idea, as I don't know what sugar you're using. I do know that cancer loves glucose, see the Warburg Effect. I also know that some have seen benefits from a Keto diet, eliminating sugar and forcing the metabolism to rely on ketosis, rather than glycolysis, for energy. Cancer is unable to use ketosis.
@daleval2182
3 ай бұрын
@@LanceHitchings Glycine is sweet as what the video is about, it is a type of simple sugar, but not sure if it's enough to matter if it's along with NA C
@scottk1525
Жыл бұрын
Just to clarify. Yes, *exogenous dietary and intervenous* antioxidants have largely failed to show any positive benefits. The reason being that the vast majority of ROS are created within our cells where they damage DNA, and dietary antioxidants make it in our blood, but not into our cells where they are needed. But if one can increase their endogenous, intracellular production of antioxidants, then they most certainly have beneficial effects, because they are being produced right there within the cell, and can therefore actually interact with ROS. This is why intervention where antioxidants are fed to mice fail miserably whereas interventions that boost endogenous antioxidants show a lot of promise.
@joecam21
6 ай бұрын
Glycine & NAC made me sick, causing bad headaches, and anxiety, and lasted for a week.
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