An introductory lecture and review of foundational concepts in molecular biology and genetics, as well as an overview of nomenclature rules and international standards. The material is suitable for a wide range of audiences, from undergrad to graduate levels, for academic researchers, medical students, residents, and anyone interested in the topic.
Errata:
1:28:36 Fusions are now designated with the double colon '::' (i.e. BCR::ABL1) since there was inconsistency in the use of hyphens and forward slashes historically [pubmed.ncbi.nl...].
The Basics (Central Dogma)
1:19 The Human Genome
5:10 Nucleic Acids
10:09 Chromosomes
14:22 DNA Replication
17:00 Replication Animation
20:36 DNA Repair
24:08 Structure of a Gene
26:19 Transcription
28:16 Transcription Animation
30:17 Post-transcriptional Processing
31:36 Splicing and Alternative Splicing
34:40 Translation and the Codon Table
38:24 Amino Acids and Protein Structure
41:18 Translation Animation
44:27 Post-translational Modifications
46:10 Epigenetics
Genetics
50:45 Mendelian and Non-Mendelian Genetics
51:56 Hardy-Weinberg Equilibrium (Population Genetics)
55:20 Useful Terms
56:46 Inheritance Patterns and Interpreting Pedigree Charts
1:03:39 Variants, Mutations, and SNPs
1:08:26 Types of Mutations
1:11:23 Oncogenesis
Nomenclature
1:13:13 Letter Code
1:14:56 Genes and Proteins
1:16:12 Sequence Variant Reporting
1:19:27 International System for Human Cytogenomic Nomenclature (ISCN)
1:19:50 Locating genes
1:21:50 Interpreting Cytogenetic Reports
1:28:36 Interpreting FISH Reports
1:36:27 Interpreting Microarray Reports
Reference:
Codon Wheel: journals.asm.o...
Post-translational Modifications: www.thermofish...
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MEDICAL DISCLAIMER
hikmapress.wor...
Негізгі бет Molecular Pathology and Cytogenetics I - Foundations (Molecular Biology, Genetics, and Nomenclature)
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