his explanations are so clear and concise. How can you not like his lectures?
@brendamorgan5321
4 жыл бұрын
I am so grateful for all of the AK Lectures BioChemistry lectures. I can’t thank you enough.
@Gianlu1912
7 жыл бұрын
I think there is a mistake on the last step, the one which involves the 2,4-dienoyl-CoA reductase: the reaction requires a NADPH (+ H+) to reduce two of the four carbons involved in the double bonds, instead of NADP+, otherwise that would mean a further oxidation of already oxydated carbons.
@samihaafreen8120
5 жыл бұрын
Gianlu1912 u r right. The reaction uses NADPH & H+ and release NADP+
@user-sm1lm3lo9c
4 жыл бұрын
Yeah u are right 👌
@drewborgholthaus2010
3 жыл бұрын
Yeah, you're right. Because you're adding two Hydrogens, one at carbon 2 & the other at carbon 5, and the electrons must perform some sort of radical intermediate in order to form a double bond between carbons 3 & 4. Simple error.
@cornflakes3851
3 жыл бұрын
Yes u r crt....💯💯
@HuyAvocado
2 жыл бұрын
Yeah
@afnansalam3670
7 жыл бұрын
Thank you for saving us in biochemistry! ❤
@hebashihab3766
6 жыл бұрын
Afnan S. You are right However english is not my languge ,he explane it better than my doctor thank you Mr,AK
@IlPiccoloNerd
4 жыл бұрын
Thank you very much for your lectures. Sometimes books take for granted facts and explain mechanisms and processes without giving any reasons for what is happening. For example, in this case, I could not understand why a reduction reaction was needed. You simply explained that it was because the conjugated intermediate was not a substrate of the enzyme hydrolase and so a different reaction was needed. I don't like learning without thinking, only memorizing stuff putting no logic into it. That's what I like about you. You always explain WHY something is happening. You're an inspiration. Thank you very much. I'll pass my exam thanks to you.
@jetsetter8541
7 жыл бұрын
With this knowledge you're the most suited scientist to develope supplements and medications to correct the missing links in our metabolism . I loved organic chemistry in school.
@dana102083
4 жыл бұрын
or how about to eat a diet that would be best suited for health, to eliminate the need for medications? Who wants to be on medications for life if health was an option all along?
@STK11196
8 жыл бұрын
So glad you did this video! Phenomenally clearer than my lecturer haha
@AKLECTURES
8 жыл бұрын
+Samueltk awesome! Thanks bud!
@SayWhaaaaaaaaaaaaaaaaaaaaaaat
8 жыл бұрын
Your videos are SUPERB. most of such videos are like punishment to listen, but yours..very easy and interesting.
@Sol-zd4nd
8 жыл бұрын
Welcome back!I was wondering when the next video would be uploaded,I am a student studying at a difficult country, and I get a lot of help from you, Thanks! :D
@bilalsher7334
7 жыл бұрын
you have made biochem easy with your concise and free flowing knowledge.keep it up
@CitraTheKrumZ
8 жыл бұрын
thank you for posting this video, thank you for coming back, a bit of correction, when enzyme 2,4-dienoyl-CoA reductase works, it requires NADPH + H+, forming NADP+. not the other way around, please check. thank u
@AKLECTURES
8 жыл бұрын
+CitraTheKrumZ Thank you! You're right. I added an annotation with the correction!
@CitraTheKrumZ
8 жыл бұрын
+AK LECTURES (Andrey K) women are always right hhahhaha,, naahh I'm just kidding.. glad i can help ;)
@AKLECTURES
8 жыл бұрын
CitraTheKrumZ Can't argue with you there :-)
@CitraTheKrumZ
8 жыл бұрын
+AK LECTURES (Andrey K) i've checked d video, and you really add the annotation, thank u.. anw i'm still curious how a math grads can end up in med school? =D
@julie4583
7 жыл бұрын
+AK LECTURES (Andrey K) then the intermediate is reduced and not oxidized as mentioned right?
@ogunyemisherif1638
2 жыл бұрын
Thanks so much. Your videos have been beneficial to me as a Nigerian postgraduate student. In the reaction involving 2,4-dienoylCoA intermediate, NADPH should be used up to generate the oxidized form. Thanks.
@peyton-
8 жыл бұрын
I have an exam over this material this week! Perfect timing.
@teodorkiritsov2677
4 жыл бұрын
Did you pass?
@peyton-
4 жыл бұрын
@@teodorkiritsov2677 Haha yes, I'm a licensed pharmacist now
@teodorkiritsov2677
4 жыл бұрын
Awesome good for you
@Kirkeuglen
8 жыл бұрын
Great to see you back! You're amazing.
@biplovshrestha1608
3 жыл бұрын
What if the single double bond is present in even number carbon?
@yulemfany2067
10 ай бұрын
I think the process is okay but where we use 2,4 dienoyl coa reductase,We use NADPH and H ,becoz we are adding 2H at C2 n C5
@HuyAvocado
2 жыл бұрын
If 1 NADPH => 3 ATP and 1 FADH2 => 2 ATP So Stearic acid => 146 ATP Linoleic - 1 FADH2 => 144 ATP Linolenic acid - (1 FADH2 and 1 NADPH) => 141 ATP Right? Can everyone tell me please? Thanks (Linolenic acid -2 FADH2 because it presents 2 double bond, and +1 FADH2 -1 NADPH in dehydrogenase and reductase step)
@omarjano9757
8 жыл бұрын
Just when I bought some new fish oil caps. Thanks a lot!
@abhaybhadauria0275
2 жыл бұрын
5 years old ....still so useful✨
@rahuldas-nv5cy
8 жыл бұрын
good to c u back.. ur videos helping a lot.. thank u so much.
@chilpericarmel
3 жыл бұрын
I don't see the point on the even or odd numbers of double bonds. The illustration that @AK Lecture showed for the even C18:2n6 can be also applied to C18:3n3. Can someone helps to clarify this point? Thanks
@alensaric910
4 жыл бұрын
Great video it explains a lot but I just don't get it how double bond from last step when reductase is working how cis double bond between fourth and fifth carbon jump to the trans double bond between third and fourth carbon because reductase just give hidrogen atoms to the molecule it is not removing two carbon atoms
@sheenaserrano4614
8 жыл бұрын
hey shouldnt that be from NADPH +H to NADP and not the other way around?? by the way, your lectures are amazing! Great help for med students
@julie4583
7 жыл бұрын
but he said the reductase enzyme reduced NADP to NADPH+H and oxidized the substrate!!!
@nothisispatrick7530
5 жыл бұрын
yeah but he made a mistake. sheena said it right. it wouldnt make sense to oxidise the supstrate which then has more hydrogen molecules
@copperfire132
7 жыл бұрын
One doubt in last step 2hydrogen atoms will be added or removed as I can see two hydrogen atoms added at position no 2 and 5 in product
@anthonydcosta8354
8 жыл бұрын
Thanks a Lot sir, it helped tremendously.
@haleytheoriginal
8 жыл бұрын
i love you so much! better than any professor i have ever had
@jeankim9952
5 жыл бұрын
The palmitoleic acid goes through 3 rounds of beta oxidation until the cis acyl coA is formed, and then the enoyl coA isomerase, then continues beta oxidation etc.... but Is it 3 rounds for this particular example or do all mono unsaturated fatty acids go through 3 rounds?
@chilpericarmel
3 жыл бұрын
It depends of the location of the first double bond counted from the carboxyl end.
@sudhashanmuganath5995
8 жыл бұрын
awsome sir....love your lectures....I thought u stopped.Thanks again sir.
@arkanshsharma850
Жыл бұрын
Great explanation
@brightafterrain9115
8 ай бұрын
this was very helpful, thank you.
@leungjustin857
2 жыл бұрын
Thank you so much! You absolutely saved me for my IB Extended Essay
@epigeneticnerd4244
6 жыл бұрын
1. What occurs to poly and monounsaturated fats that go unused? Are they converted into triglycerides? 2. Say someone is on a ketogenic diet, consuming large amounts of fat. What is the signal that induces storage of fat vs oxidation? Such as how maxed out glycogen storage results in triglyceride formation, in terms of carbohydrate consumption.
@geneadrianreyes1987
2 жыл бұрын
Can anyone help me out what products occur from oxidation of unsaturated fatty acids?
@kristinastajdohar1080
7 жыл бұрын
Finally I get it, thanks!
@nmanhas
8 жыл бұрын
Welcome back Andrey! Guess you had enough time off from your medical studies to post more videos! Awesome stuff, really appreciate your awesome videos
@AKLECTURES
8 жыл бұрын
+nmanhas thanks! spring break gave me a few extra minutes :)
@user-jw6zt2kl5o
23 күн бұрын
Thank you oooh sir ❤
@briantracy271
8 жыл бұрын
man welcome back !
@salonimewara195
3 жыл бұрын
Thank you for such simple explaination
@ridsbutterfly9850
8 жыл бұрын
You made it all very easy sir!Thank you..
@ruaaahmad866
2 жыл бұрын
Thank u soooooooo much , U are the best !!!
@mohammadmahmoudiazar2773
7 жыл бұрын
U are awesome man.u answering all of my questions
@yulemfany2067
10 ай бұрын
What if the compound has triple bonds,how will be there beta oxidation process
@basmaalshwehdi9051
5 жыл бұрын
Thank you sooo much !!!
@Martis_1111
5 жыл бұрын
Awesome explanation sir
@wizardatmath
7 ай бұрын
I'm still wondering how/if this impacts on mitochondrial health
@swapnilombale4329
4 жыл бұрын
Very well explained .. thank u sir!😊🙌
@obinnadelight9699
5 ай бұрын
thank you so much
@nadeemaboganima4493
5 жыл бұрын
How is it that the double bond was moved from the the ninth carbon to be positioned between the third and the fourth carbon in the polmitolate ?
@chavithradesilva8494
8 жыл бұрын
sir your videos save me lot :) you're awesome .
@jesseroman9542
7 жыл бұрын
Can unsaturated fatty acids be synthesized from glucose?
@MikeFrame
7 жыл бұрын
omega - 9
@prazysilva4379
Жыл бұрын
Very nice
@tanmaygarg_9025
4 жыл бұрын
thank you sir for this lecture
@s0nip
7 жыл бұрын
how many rounds of beta oxidation are needed to oxidate it at the end?
@minahilnadeem4647
Жыл бұрын
4
@lanana939
5 жыл бұрын
This is great, thank you!!
@shanikhan00
8 жыл бұрын
the beast has returned. are you in school or making youtube videos exclusively?
@mikkokylmanen9296
7 жыл бұрын
Great stuff, thanks a lot. I was just wondering if all dietary PUFAs are equally readily oxidized for energy production, or if the number of double bonds (or other competing metabolic functions, e.g. in case of AA, EPA, DHA) affect the utilization. In other words; if one didn't eat enough calories, would his omega-3-supplements be as readily catabolized to energy as any other fatty acids?
@DP-sb3kg
6 жыл бұрын
In the last product, did you mean to draw a double bond between Carbons 2 & 3?
@hebashihab3766
6 жыл бұрын
Can you tell me how we can beak down palmitoleic acid in starvation ??
@yaraelbanna8289
6 жыл бұрын
god bless you , thank you
@aliinchains
Ай бұрын
Brother what on earth is an apatacide?
@deepakmittal6571
6 жыл бұрын
Can u please tell why enoyl hydratase enzyme can't act on this
@karass5616
6 жыл бұрын
thank you SO MUCH
@ran9628
6 жыл бұрын
thanks great video!
@jefflinks6532
5 жыл бұрын
Thanks Ak lectures for yet another life-saving video!
@purnimadupak5542
5 жыл бұрын
Thank you
@almotazalzeer9679
8 жыл бұрын
Thanks a Lot
@ijasahammed1630
5 жыл бұрын
Pls anyone at which carbon the oxidation takes place at 2;4 dienoyl coa. With help of reductase.
@bpoole99251
8 жыл бұрын
Hey, Hey! Great timing as I am going back over MCAT material. Glad to have ya back!! Hey any possibility of Psychology/Sociology future videos?
@nikarta1
8 жыл бұрын
Hey Genius, can you please so a video on pulmonary function tests??👍🏽🙏🏽🙏🏽🙏🏽
@ijasahammed1630
5 жыл бұрын
Why enoyl coa hydratase could not act on 2 4 dienoyo coAs alpha and beta carbon while it could act on trans delta2 enoyl coA
@ijasahammed1630
5 жыл бұрын
May be because of structural difference...
@quincy22
7 жыл бұрын
Shouldn't it form trans delta 2 enoyl CoA instead of trans delta 3 enoyl CoA?
@imyexoplanet8267
6 жыл бұрын
Quincy Madunezim yes
@almotazalzeer9679
8 жыл бұрын
جزاك الله خيرا
@drevenezeliezko3115
5 жыл бұрын
love u man
@AKLECTURES
5 жыл бұрын
@fairytailfan02
3 жыл бұрын
Now I'm because our biochemistry tchr refuse to discuss this and now we're apparently having an exam -_-
@eva4basketball
8 жыл бұрын
Why three rounds of beta oxidation?
@julie4583
7 жыл бұрын
it should be two right?
@umarhasnain7369
3 жыл бұрын
Three rounds just to react with the saturated bond of Linoleoyl CoA. Then after that, it encounters the double bond part.
@jdhdbbxbxh6823
6 жыл бұрын
is it always 3 beta oxidation cycle apart from the number of carbon atom ?😁😅😅
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