Instructors: Christopher E. Mason
Lecture Summary: In this lecture, Christopher E. Mason, PhD, Professor of Physiology and Biophysics, describes the ethical implications of genetic and transcriptomic sequencing and debates surrounding the implementation of genetic screening, CRISPR-gene editing, and other novel biotechnologies. He describes in depth the intersection between law and science, from criminal cases to gene patents.
Course Summary: Sequencing-based research has become the dominant investigative practice within the biological sciences. Single-molecule sequencing: training, methods, and applications, responds to this development by providing a hands-on and in-depth introduction to sequencing for students, from Sanger to third-generation technologies. Utilizing an alternating lecture-lab schedule, students are introduced to fundamental basic principles of DNA & RNA science, progressing to cutting-edge library preparation and sequencing analysis techniques with Illumina and Nanopore technologies. Students will have the opportunity to perform direct-RNA sequencing samples on research samples, and experience first-hand the ethical implications of this data. Relevant concepts in biology and computer science will be addressed.
Relevant Papers:
The Supreme Court should invalidate the patent on human DNA, www.washingtonpost.com/opinio...
The Yale Information Society Project 2008-2009 Accomplishments, law.yale.edu/sites/default/fi...
Mason CE, Seringhaus MR, Sattler de Sousa e Brito C. Personalized genomic medicine with a patchwork, partially owned genome. Yale J Biol Med. 2007 Dec;80(4):145-51. PMID: 18449389; PMCID: PMC2347364.
www.ncbi.nlm.nih.gov/pmc/arti...
Course website: physiology.med.cornell.edu/fa...
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