Complete hunch here. I reason that the breathing portion of Wim Hof method promotes mitophagy. Why? I cured afib with the method. Afib is related to mitochondrial dysfunction. Upon first beginning, or resuming the method after a long break, oxygen saturation does not max at 99% on a pulse oximeter. It takes time to work up to that. My hunch is that healthier mitochondria are selected and grown during that time, while less fit mitochondria are eliminated. I am so much healthier now with just this and time restricted eating. It is a night and day difference. Thanks for all you do.
@flyiniron1221
Жыл бұрын
Right ON!!! I have ALS and WIM works for ME! Fasting TOO!
@evanebert8291
Жыл бұрын
I also speculate that WHM breathing elevates mitochondrial function, and a lot of that could be tied to dispensing with weaker mitochondria.
@baigish100
Жыл бұрын
@@flyiniron1221 good luck to you
@richieheetebrij8189
Жыл бұрын
You are onto something!!
@jdram58
9 ай бұрын
I think art of the key is fasting most people dont understand the power of what happens but I have fasted a lot and there are hacks these days to make it even easier mainly Bullet proof coffee or tea with MCT oil or butter n salt. It doesnt sound appetizing but its purpose is to knock down ur grehlin or hunger hormone n it does that quite well to enable to put your body in a fastive state without too much uncomfort say to skip a meal like breakfast n wait for say noon or later for your first meal of the day. So its like a training plan for fasting which will becomes easier and easier over time for those who've never tried it. to try and get their body into ketosis when their insulin level drops and their body starts getting energy from fats stored inside their body verse something they eat like carbs or sugars, Believe me its a strange feeling almost like spiritual cuz your no longer hungry or craving food yet you have plenty of energy. James the apostal.
@LanceHitchings
9 ай бұрын
Great advice. Check out my videos on Bulletproof coffer or fasting.
@davidg.johnson7208
Жыл бұрын
Who says you can't buy health! I take a handfull of supplements in the morning and a handfull in the evening. If I keep watching these KZitem videos, I'm going have to take a loan out!
@LanceHitchings
Жыл бұрын
I hear ya, brother. I spend more on supplements than I do on food.
@cryptobiose4809
8 ай бұрын
@@LanceHitchings😂
@aluna_m888
4 ай бұрын
Same here 😂😂😂
@lightfast1
Жыл бұрын
Very interesting. Please do a segment on PQQ
@richieheetebrij8189
Жыл бұрын
The precursor is found in rose hips. When I eat rose hips I get mega strength and endurance.
@supremoluminary
2 жыл бұрын
Pronunciation: u ro ‘li thin What specifically is converted to Urolithin A? Ellagic acid?ellagitannins? (And if so, which?) Which bacteria do the conversion? Because you stated in your video, Urolithin A is produced in the gut from certain compounds by certain bacteria. How can you know this to be the case? Where was the conversion observed? Gut production of Urolithin A is hand waved. What’s the maximum safe level of Urolithin A to intake? What happens with over supplementation, such as for people who produce Urolithin A, and also supplement it? Is the excess useless or harmful? You said Urolithin A also “blunts inflammatory responses“. Does it? Or is that an effect of increased mitochondrial functioning, reducing the deleterious effects of ROS? Or is it an effect of removing damaged mitochondria which are known to produce inflammation?
@Rafas216
Жыл бұрын
muitas perguntas Garrett.... suas dúvidas deixam você acordado a noite pensando e produzindo menos urina A.
@rickvsez8774
2 жыл бұрын
Thanks again, Lance. indeed very expensive substance so hopefully it will become cheaper in the future. Definately one to keep in memory. Since this topic interrests me a lot, I Wondered: Are you planning on talking about 'telomere lengthening oxygen therapy' some time?
@El1t3
2 жыл бұрын
It works. Make sure you choose to do it in a place with a pro machine for HBOT.
@asdsafgae
2 жыл бұрын
What do you think about PQQ supplementation? There are studies that claim to increase the number of mitochondria with PQQ among many other benefits. Do you recommend PQQ?
@jimdandy8996
Жыл бұрын
Would take with alpha lipoic acid
@TheGriff2004
Жыл бұрын
I've been taking urolithin A for about 6-7 months and have seen significant gains in strength but where this really shines with me is endurance. The improved endurance is very clear. (Shocking actually) It is quite expensive though. 46yo male, works out 3 to 4 times a week. (ish lol)
@georgeikinya2779
Жыл бұрын
At 46 and working out 4 times a week??? Why take it really???
@TheGriff2004
Жыл бұрын
@@georgeikinya2779 I started taking it for improved endurance. I noticed an improvement fairly quick (2 weeks ish) but thought it had to be placebo. After 6 months it still remains.
@LanceHitchings
Жыл бұрын
That's great to hear. It one of the things that I'm considering adding to my protocol.
@MrStu
Жыл бұрын
Which brand are you taking?
@TheGriff2004
Жыл бұрын
@@adrenalinejunkie3828 I'm using RenUAl by pure encapsulations. 👍
@danielmoser2741
Жыл бұрын
Terminalia chebula is a tree that also has urolitin A. Ayurveda in Haritaki Powder.Myrobalanen,Haritaki as part of Triphala ... Thank Lamce for you good Info ... Wounderful
@iosefzidrunas1547
Жыл бұрын
In the first days of taking Urolythin A, endurance increased. HOWEVER! After a week's (500-900 mg per day) - I felt my physical strength gradually decrease... I am 52 years old, and usually I actively train 4-5 times a week (strength exercises or cardio) and have always been happy to strive for training. But then, after Urolithin - the desire to train - disappeared! And after 3 weeks - there was not only physical fatigue, but also mental passivity... Urolithin stopped taking. Maybe my experiment is too short... I usually recover quickly after a workout... and such a long fatigue was unbearable... Therefore, I decided to end Urolitin for now. It's been 2 weeks - but the old strength, the old desire to train - still haven't returned! So all supplements that cause MITOPHAGY are probably suitable for people who are very adult and not engaged in sports... Maybe it's just me who has this reaction. (Urolithin A was taken in parallel with the use of PTEROSTILBENE and NMN)
@cryptobiose4809
8 ай бұрын
Maybe it's the mix of these 3 suppléments the problem? To recover liposomal vitamine c &B12, régulatpro bio,shilajit,Immun'Age,Moléculaire Hydrogène could help?Best regards.
@gitanjalinandan
2 жыл бұрын
Lance do you rotate through at least some of your supplements or do you take all of them each day?
@AtEboli
Жыл бұрын
I would like to know the differences between those supplementing with Urolithin A, and those adopting a rigorous program of exercise, in terms of mitochondrial health and functioning. My guess would be that exercise may be more effective than taking this pill, a lot less expensive, much more readily available, and would have many other benefits to health beyond mitochondrial function.
@sullustanmel
Жыл бұрын
Better - combine them if you can afford it
@miked319
2 жыл бұрын
Lance you're right! Why is this so expensive? It doesn't help anyone!
@ScottSummerill
2 жыл бұрын
How about pomegranate extract to avoid the sugars? I actually have some. Also blueberry extract. That doesn’t address the conversion issues but I assume the precursors would be there.
@derekmcqueen4589
2 жыл бұрын
Good idea! I guess you would take the extract for a month and see if your levels Urolithin A went up
@rebeccaaldrich3396
Жыл бұрын
I just bought some pomegranate extract. I'm hoping for a good result.
@shilk4301
Жыл бұрын
The issue is we need the right kind of gut bacteria for that . How is your experience so far .
@markaguilera493
Жыл бұрын
Nothing wrong with the sugars, your body is made to handle them.
@robertallair7278
2 жыл бұрын
Thanks Lance for another interesting video. Based on your presentation, urolithin A looks interesting but the results don’t seem strong enough to justify a big expenditure. Personally I plan to keep up the NO release exercises to improve/maintain mitochondrial health, and rely on fasting and other supplements for senolysis. Cheers!
@JazenValencia
2 жыл бұрын
You can buy 25 mg of Urolithin A for like $147 cheapest I've found. and you need 1000 mg a DAY! in these trials for minimum benefit. not worth it.
@katrecemiller8325
2 жыл бұрын
It’s just 7 days and the outbreaks are well treated and unseen. Thank you so much Dr. Aloha #Autism #Cancer #Herpes for curing my HSV 1&2 completely. 🌱🍵kzitem.info/rock/_YFEEZEr1BxGkNg1d4vqww 💝 📌
@ingride3719
2 жыл бұрын
What kind of exercises improve mitochondrial functions??thank you 🙏
@buck8055
2 жыл бұрын
Thanks for the information Lance. Just as an FYI, around 8 min in your say 500 grams rather than 500 mg, which is the daily dose provided by the Time Line supplement. I’ve started taking it and it is very expensive. I’m only a few weeks in and will be very interested to see if I pick up some strength in my workouts after a couple of months. Thanks again, as always, for your great information.
@chrismyers9951
2 жыл бұрын
Drink pomegranate juice instead.
@QuantumOfSolace1
2 жыл бұрын
Too many carbs and sugars in the juice
@supremoluminary
2 жыл бұрын
@@QuantumOfSolace1 The problem with drinking pomegranate juice is not necessarily the amount of sugar, but the inability to know if it will be effective. What is the tannin content in the pomegranate juice? And what is one’s individual ability to convert those tannins into Urolithin A? If 40% of the general population are converters, the odds aren’t in your favor for drinking pomegranate juice to have any effect on Urolithin A levels.
@zebragiraffe1
2 жыл бұрын
@Buck How is it going? I'd love to know if it truly can slow down effects of aging.
@edisonclaro5363
2 жыл бұрын
thanks .I will probably try the Urolithin A too.
@sonnygmony
Жыл бұрын
It's worth considering a mitophagy flush similar to a fisetin autophagy flush
@JazenValencia
Жыл бұрын
I was wondering the same thing. It makes sense.
@dessleonid
Жыл бұрын
How to take Urolithin A? after meal, during the meal or on empty stomach?
11 ай бұрын
No one tell ...
@dalebullock810
2 жыл бұрын
There is a company working on this and are developing a test for potential consumers to determine if they are converters.
@Mask-pb3ly
2 жыл бұрын
Could you tell the name of this company. I tried to consume Urolithin A for one month but cannot tell if it helps me.
@dalebullock810
2 жыл бұрын
@@Mask-pb3ly I don't remember. You can look it up.
@karenfarrell6158
Жыл бұрын
Someone commented online that with the urolithin a supplement their blood lipid panel came out quite negatively. Maybe the studies need to continue
@Padraigp
4 ай бұрын
Whats a negative blood lipid panel? Low lipids? Which lipids? High lipids? Which ones.
@CannabisRex
2 жыл бұрын
Never heard of it before, Lance. You have great videos. I would like to see some graphs in this one, though, instead of just showing the studies. But in this case it wouldn't have mattered anyway, and I am even wondering a bit about why you bothered to make this video. But thanks, anyway.
@fariborz13451345
2 жыл бұрын
Hi Lace. Thanks for the information and interesting topics. I just joined your channel. Since you implement what you've learned and studied may I ask how old are you ?
@YOURRAINBOWBRIDGE1111
Жыл бұрын
I just left an excellent presentation by 2 DR/scientists who are using this product and highly recommend it So I am on a quest to learn as much about it as possible Both of them were very positive about it and said they use it themselves That is a pretty great recommendation
@davidchung1697
Жыл бұрын
Lance - it has been a while since you uploaded the video, so you probably won't this post ... Just wondering if you had seen any results from taking urolothin-A (Mitopure). I recently came across a study on pomegranate juice - which most likely contains the substance that converts to Urolothin-A. The study showed significant improvements in exercise performance from those who took pomegranate juice. My guess is that the improvements are were to urolothin-A. Also, what the study indicates to me is that pomegranate extract may work as just as well as Mitopure - if you are a lean individual. It is certainly much less expensive than Mitopure.
@LanceHitchings
Жыл бұрын
First off, I can't afford Mitopure, so I haven't taken it. Just reporting on the science. I have taken a lot of pomegranate juice, but I take so many supplements that it's really hard to pin down what effect was caused by what supplement. All I know is, I feel like I'm getting great results, overall, from everything I do.
@davidchung1697
Жыл бұрын
@@LanceHitchings Lance - thanks for responding. Just saw your stem cell treatment video - it is interesting stuff.
@bobwhite4748
2 жыл бұрын
Lance do you abide by the school of thought that you crave what your body needs? I craved salmon for yrs once I started taking dha/epa the craving waned? So the fruit I prefer or like to eat is mixed berry, blue berry raspberry strawberry blackberry. Your thoughts? with regards to increasing my urolithin A.
@ChessMasterNate
2 жыл бұрын
Your body....and whatever other creatures or viruses are in you. Viruses always scream for sugar. When you get a cold, it is best to ignore that message and hit the chicken soup. There are also a few addictive foods. There is a substance in cheese, for example. I think the companies that make cheese puffs and such take advantage of this and add more of it. "Cheese contains casein, a dairy protein that releases casomorphins, which are plant compounds that trigger dopamine production in your brain." And very toxic Advanced Glycation End Products (AGEs) are addictive substances made in the Maillard browning reaction. This was probably a survival thing from times of old when you were better off eating meat that was fully cooked rather than potentially getting something that will give you parasites. Those AGEs can kill you as they accumulate, just later in your 60s, 70s or 80s by hardening your tissues and causing inflammation. Bodies are also about habit. If you meet needs in the same ways, and it works, your body will remember. But as you pointed out. If the needs are met with something else, that craving may not happen much, after a time.
@larsnystrom6698
Жыл бұрын
I wonder if you have to take this kind of supplement daily. It seems to me that, if it works, intermittent use would work just as well. Although, that way of using it might be too complicated for the researchers. So I doubt we will get that kind of result from them, Mitophagy, and anything improving the mitocondria, is very interesting. I belive that's one of the big things in aging.
@LanceHitchings
Жыл бұрын
I agree with your comment about the mitochondria. Really interesting stuff.
@reginaldwilliams3875
Жыл бұрын
pom wonderful !!!!
@eyera18901865
2 жыл бұрын
Anything that claims to cause mitophagy has to prove it can distinguish old vs new mitochondria . Fatigue is a known side effect of this product which is likely caused by destroyed mitochondria. I could not tolerate it. I would avoid it. Ira Goodman MD
@Mask-pb3ly
2 жыл бұрын
I am really interested by information that destroyed mitochondria causes fatigue. Is it proven information?
@kkostadinof
2 жыл бұрын
@@Mask-pb3ly Mitos are the powerhouses of the cells. Fewer mitos =less energy production=fatigue.
@quasarhi
2 жыл бұрын
Anyone reported fatigue with Pomegranate/Blueberry extracts ?
@jimshu245
Жыл бұрын
No fatigue reviews on Amazon!
@iosefzidrunas1547
Жыл бұрын
@eyera18901865 Said exactly! In the first days of taking Urolythin A, endurance increased. HOWEVER! After a week's (500-900 mg per day) - I felt my physical strength gradually decrease... I am 52 years old, and usually I actively train 4-5 times a week (strength exercises or cardio) and have always been happy to strive for training. But then, after Urolithin - the desire to train - disappeared! And after 3 weeks - there was not only physical fatigue, but also mental passivity... Urolithin stopped taking. Maybe my experiment is too short... I usually recover quickly after a workout... and such a long fatigue was unbearable... Therefore, I decided to end Urolitin for now. It's been 2 weeks - but the old strength, the old desire to train - still haven't returned! So all supplements that cause MITOPHAGY are probably suitable for people who are very adult and not engaged in sports...
@Alice-oe4kd
Жыл бұрын
Does this affect mitochondria other than muscle mitochondria - specifically the brain?
@theadventurehunterdan
10 ай бұрын
any update on a self trial?
@johnvogt621
Жыл бұрын
Happen to know of places that sell this supplement?
@JMSsssssss
5 ай бұрын
It doesn't sound worth the cost to me, honestly, without more convincing data.
@Shakedown24Seven
Жыл бұрын
Why would you wait until the end of the tube to tell me it doesn’t seem to do much? 😒
@tammygravis1462
Жыл бұрын
Vaccine injured is this the best for energy or ATP?
@jamesharter4973
2 жыл бұрын
I took mitopure for 6 days. And it made me lose sleep my body is hooked on it this is torture.
@jamesharter4973
2 жыл бұрын
Apparently, this only happens to a small percentage of the population butt I am back to normal now. If you get a brain boost from nad+ boosters mitopure may not be for you.it's vary addictive
@LanceHitchings
2 жыл бұрын
Thanks, good to know. Everything works differently in different folks. I haven't tried mitopure.
@markveen1373
2 жыл бұрын
Is the precursor ellagic acid heat sensitive? Because I eat pomegranate jam sometimes.
@DeeneMuada
Жыл бұрын
where can i buy this? i cant find it
@fredmontana1137
2 жыл бұрын
Its pronounced EURO-lithin not U-ROLL-ithin
@carolestewart2867
9 ай бұрын
Sure sounds like you got the jabbaroo. Your voice sounds sick! This is happening to so many people since 2020. Look into protocols that involves augmented NAC, Natttokinace and bromoline.
@bryantcofty2709
Жыл бұрын
What's the best brand?
@LanceHitchings
Жыл бұрын
I have no preference between there 2, but I think the top 2 brands are DoNotAge and MitoPure.
@ChessMasterNate
2 жыл бұрын
2 seconds in, I see you have trapped yourself in a corner. Are you pushing the desks around, or climbing over/under them? :) I suppose it is exercise, maybe even HIIT exercise.
@Niksky2
2 жыл бұрын
What happened to your voice?
@Rafas216
Жыл бұрын
bebeu urina
@denizkurtulus8946
2 жыл бұрын
Hey Lance, thanks for the video, I sent you an email, is it possible for you to look it up when you have time, Best
@royedwards51
Жыл бұрын
My dude is pronouncing it incorrectly
@joshydillens148
2 жыл бұрын
hey love your content but dislike the intro, especially the clubby music
@michaelacton6246
Жыл бұрын
Yea will skip it that would double my anti aging supplements for a month supply. Rather spend that on mot c and 5 amino which I plan on adding to mitochondrial stack sometime this year.
@meiyuc22
Жыл бұрын
14% vs 10%, just placebo effect, that's all.
@ChessMasterNate
2 жыл бұрын
The carb issue is rubbish. Look at the associations in methylation in the GrimAge methylation clock data. More carbs means a longer life. More fat means a shorter life. Protein makes little difference. The anti-high fructose corn syrup craze is also bunk. It was not the cause of the obesity epidemic. If it were, obesity would have gone down from 2000 to 2019, because we went from eating 62.5 lb to 36.7 lb of the stuff. But that is not what happened, obesity climbed dramatically in that time. 21.8% to 31.3% (self-reported. People exaggerate their height and take a few pounds off their weight when surveyed. But they likely lied as much in 2000 as 2019. When people are actually measured, there is around 10% more that are obese). The actual cause? Likely it is the unabated spread of Adenoviruses 5, 36, and 37. That really took off in the 1980s. When animals are infected with these, they also become obese.
@lauchlanguddy1004
Жыл бұрын
mmmmmm basically no gross obesity in europe but supermaket fare is very differentb to english speaking countries
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