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. Parkinson's disease is a progressive, neurodegenerative disorder of melanin-containing dopaminergic-neurons in the anterior part of the substantia nigra pars compacta.
Macroscopic morphology is that substantia nigra pars compacta and locus coeruleus look pale due to the degeneration of dopaminergic nerve fibers in the anterior part of the substantia nigra pars compacta.
Microscopic morphology is that there is an accumulation of Lewy bodies in the neurons which block the neurotransmitter release.
Dr.Mobeen Syed explains the role of alpha-synuclein proteins in apoptosis.
Due to gene mutation, there is a polarity change and multiple proteins clumb up together. They end up making beta-pleated sheets that make fibrils. These fibrils capture some proteins with it which are necessary to inhibit ubiquitin proteins. So ubiquitin proteins are free to perform apoptosis. The dopaminergic cells die.
The other theory says that Lewy bodies disrupt the functions of antioxidants and mitochondria. They disturb the neurotransmission. The cells start functioning less, and the dopaminergic cells die.
So once substantia nigra pars compacta start degenerating, the thalamus becomes disinhibited and rigidity starts appearing.
The following topics have discussed in the video:
* Macroscopic morphology of Parkinson's disease
* Microscopic morphology of Parkinson's disease
* Concept of Lewy bodies
* Role of Lewy bodies in Apoptosis ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
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