Thank you SO SO much for uploading these for us non-students too, professor. Learning and keeping my brain occupied is really saving my mind and sanity during this quarantine. I’m retired and can’t visit anyone. Thank you.
@phabove7
3 жыл бұрын
And there are some idiots who disliked a top quality science lecture. 🤦♂️🤦♂️ Thanks Professor for improving our knowledge and making us more aware.
@michalchik
3 жыл бұрын
I think I might like this video even more than the equivalent classroom lecture last year, but both are a boon to those of us who didn't get to take virology during our undergrad
@animalparty8206
3 жыл бұрын
Thank you Dr. Racaniello! I am listening to all of these lectures, some of them multiple times until I feel like I understand the information. The animations are so cool!
@vesa-mattipuro5696
3 жыл бұрын
Prof Vincent Racaniello, thank you for this openly available virology course, it's great! I have studied MSc of information technology, but love learning something new. I am also a regular viewer of TWiV and I now am watching 2021 lectures, this is second time after last year watching 2020 lectures of the same course. I am just wondering who would be a similar authority in the field of epidemiology than Prof Racaniello is in virology and hopefully would have made a course available in the Internet about epidemiology in such detailed content than this course is about virology? Or have the best textbook?
@lisinsignage
3 жыл бұрын
Wahoo, these viruses are programming geniuses 👍
@bardacha100
3 жыл бұрын
This vid deserves 7 billion views not 9201... !
@jamesmyers777
3 жыл бұрын
Man, this lecture is complicated!
@mansbreimer
3 жыл бұрын
Thanks so much for doing this. So important in these times that as many of us as possible understand how these things work and affects us.
@nicevideomancanada
2 жыл бұрын
I followed all of that. Thanks. Next.
@wboyle9721
3 жыл бұрын
Amazing Prof Vincent thank you from Glasgow scotland
@simoncelt5590
3 жыл бұрын
Totally concur
@tomsteinberg8106
3 жыл бұрын
Template switching and recombination (@37 min). V.R., this is wonderful stuff.
@camresearch5120
2 жыл бұрын
I sent you a message in FB
@gcm4312
3 жыл бұрын
Maybe this was discussed before, but I'm very curious as to how Sinovac was able to develop the inactivated virus vaccine (Coronavac) so quickly. I think I understand the quicker development times for mRNA vaccines but I do not understand how Sinovac was able to do it. Could you guys explain it at some point? There must have been some amazing breakthroughs.
@JenniB123
3 жыл бұрын
What "amazing breakthroughs" are required to make an inactivated virus vaccine?
@gcm4312
3 жыл бұрын
@@JenniB123 the usual process of developing innactice virus vaccines takes years afaik. I'm not an expert hence my question and curiosity about the subject.
@JenniB123
3 жыл бұрын
@@gcm4312 My understanding is that inactive viruses are the easiest to make. What takes years is the clinical trials.
@2listening1
3 жыл бұрын
I love this lectures, Dr. Vincent !
@sukh6566
Жыл бұрын
amazing lectures thank you
@westfield90
3 жыл бұрын
Did you know that Israel has vaccinated almost 50% of their population. I think they will be able to tell us if herd immunity actually kicks in and when or is it just a theory, They likely will have their entire population vaccinated in a month. That is remarkable but they do have a very small population compared with other nations so a perfect case study for herd immunity studies.
@lifeisbeautiful.2491
2 жыл бұрын
At 27:14, they look like some sort of animated creatures sitting and all of them looking in one direction. 😂
@simonewilliamson6766
3 жыл бұрын
Thanks so much for the videos. I have been needing a refresher on this material. I was wondering if the stuttering that occurs at the AAAA tail stops because the molecule becomes sterically hindered and can no longer add more bases.
@petergoodall6258
3 жыл бұрын
I can’t believe how beautiful all these mechanisms are. I’m glad I don’t have to answer why. How: all those random probes into the space
@xrach2006x
3 жыл бұрын
Hi Vincent, can you put the survey monkey questions on this and lecture 5? Will make it easier for me to follow along x
@bruceleidl2562
3 жыл бұрын
Help. I'm having a chicken vs egg problem with the poliovirus translation slide. If the genome is translated into a single protein which is then cleaved by 3Cpro and that protease is virus specific and a product of the translation then how does the process start? Where does the 3Cpro come from that cleaves the first protein?
@dennisw4552
3 жыл бұрын
The 3Cpro part of the polyprotein probably cleaves other polyprotein molecules. 3Cpro can still cleave with extra amino acids at either end, so it likely has some protease activity even as part of the entire polyprotein.
@toby9999
3 жыл бұрын
This is mind blowing stuff!
@pixelated_dinosaur
3 жыл бұрын
3:42 cells do that indeed, it's called RNAi=PTGS=quelling....
@natr6295
3 жыл бұрын
Thank you for these lectures!! I have two questions that I really hope someone can answer for me. 30:36 - For polioviruses, where the genome/mRNA is translated into a polyprotein that is further processed by viral proteases, do the proteases already come in the viral particle or do they have some sort of “self-cleaving” activity within the polyprotein? 47:45 - The mechanism of “priming” used by influenza virus doesn’t look like priming per se to me in that the host RNA piece is not base-pairing to the viral negative-sense RNA. It rather looks like de novo synthesis since a free GTP is first base-pairing with the 3’-most C on the viral RNA, and then the GTP and host RNA piece become bound to each other (cap-snatching). I also don’t understand why, in this example, synthesis of the viral mRNA starts from the 3’-most C of the viral RNA and not the 3’-most U. Lastly, just fyi, there’s a couple of typos in the bottom diagram for “Elongation” on the newly synthesized strand (bright green) - right now reads “pGPCpApA…” but should read “pGpGpApA…”
@dennisw4552
3 жыл бұрын
Poliovirus does not have proteases in the viral particle. The polyprotein is probably self-cleaved at first. This would require another molecule of polyprotein for full cleavage, since the 3Cpro in the same polyprotein cannot cleave between 3Cpro and 3Dpol.
@narancauk
3 жыл бұрын
''it goes stops + - + switch 3' 5' copy stops, sequence, mosquito, info.5' assembly stops start 7 met + .....................''----'It is not easy to be a Virology professor!!!!!!
@PaulAJohnston1963
3 жыл бұрын
Does the same RNA come out of a specific turret?
@ingridmuller1072
3 жыл бұрын
Thanks, I have a doubt sarscov2 has polymerase surrounded by 8-9 viral proteins , and it´s a coronavirus. I think you said around the min 6 of the video that coronavirus don't have polymerase?
@natr6295
3 жыл бұрын
The coronavirus viral particle doesn't carry the RNA polymerase *protein* within it. It doesn't have to since the RNA polymerase is encoded in its positive-sense genome. If you go to 35:00, he explains how RNA polymerase protein is made de novo from the viral genomic RNA.
@tehShikari
3 жыл бұрын
Thank you so much!!
@ayushupadhyay801
3 жыл бұрын
I love how you were gender neutral towards coronaviruses when in fact viruses lie on the line of living and dead xD
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